[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-25286-105":59,"doc-detail-25286-en":114},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":106,"head_meta":109,"extra_data":111,"updated_unix":113},105,"en","rifle-classification-for-acute-kidney-injury","RIFLE classification for acute kidney injury","","The RIFLE classification system is presented in Box 12.5, detailing grades of acute kidney injury (AKI) based on changes in serum creatinine (SCr) and urinary output (UO). The grades include Risk, Injury, Failure, Loss, and End-Stage Kidney Disease (ESKD). Risk is defined by a 1.5-fold increase in SCr within 48 hours or a UO of \u003C0.5 mL/kg per hour for 6 hours. Injury is characterized by a 2- to 3-fold increase in SCr within 48 hours or a UO of \u003C0.5 mL/kg per hour for 12 hours. Failure is indicated by a 3-fold increase in SCr or SCr >350 µmol/L with an acute rise >40 µmol/L, or a UO of \u003C0.3 mL/kg per hour for 24 hours. Loss is defined as persistent AKI for >4 weeks, and ESKD as persistent renal failure for >3 months. The document also provides context for AKI, noting it is not a diagnosis but a descriptor of sudden, often reversible renal function loss over days to weeks, frequently associated with reduced urine volume. AKI affects approximately 7% of hospitalized patients and 20% of acutely ill patients, and can occur with or without kidney parenchyma injury. The text also elaborates on pre-renal causes of AKI, categorizing them into total intravascular volume depletion (hemorrhage, renal fluid loss, gastrointestinal fluid loss, skin fluid loss, third-space fluid loss), effective volume depletion from arterial underfilling (reduced cardiac output, peripheral vasodilation), and intrarenal hemodynamic changes (glomerular afferent arteriole vasoconstriction, glomerular efferent arteriole vasodilation).",{"@graph":69,"@context":105},[70,84],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/rifle-classification-for-acute-kidney-injury/25286/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/rifle-classification-for-acute-kidney-injury/25286.png","ImageObject",300,407,{"name":92,"@type":93},"Emma Wilson","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-20","2026-05-07",true,{"@type":102,"interactionType":103,"userInteractionCount":19},"InteractionCounter",{"@type":104},"ViewAction","https://schema.org",{"og:url":107,"og:type":108,"og:title":65,"og:site_name":95,"og:description":67},"https://docshare.wps.com/document/rifle-classification-for-acute-kidney-injury/25286","article",{"robots":110,"canonical":107},"index,follow",{"doc_id":112,"site_id":62},25286,1778191878,{"code":4,"msg":5,"data":115},{"doc_id":112,"user_id":116,"nickname":92,"user_avatar":117,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":66,"file_id":118,"file_url":119,"file_type":120,"file_size":121,"view_count":19,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":122,"language":123,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":66,"faqs":66,"seo_title":124,"seo_description":67,"update_tm":113,"read_time":125},3848291630094,"https://eur-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","cbCaidqissepHMA5","https://ap.wps.com/l/cbCaidqissepHMA5","pdf",1873401,45,"English","RIFLE classification for acute kidney injury | PDF",113]