[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-331585-105":59,"doc-detail-331585-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","ribosomal-rodeo-wrangling-translational-machinery-in-gynecologic-tumors","Ribosomal rodeo - wrangling translational machinery in gynecologic tumors","","Gynecologic cancers significantly drive morbidity and mortality among women worldwide. Despite advances in diagnosis and treatment, the molecular mechanisms driving their development and progression remain insufficiently understood. This review examines how translational machinery—ribosomal proteins and translation factors—may act as drivers of oncogenic processes in gynecologic cancers, outlining plausible molecular mechanisms and assessing the therapeutic potential of targeting ribosomal components as novel treatment options.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/ribosomal-rodeo-wrangling-translational-machinery-in-gynecologic-tumors/331585/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/ribosomal-rodeo-wrangling-translational-machinery-in-gynecologic-tumors/331585.png","ImageObject",300,407,{"name":92,"@type":93},"Evangeline","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-21","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":24},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What does “translational machinery” include in this review?","Question",{"text":112,"@type":113},"It includes ribosomes, mRNA, tRNA, translational factors, and regulatory proteins responsible for protein synthesis.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How is the eukaryotic ribosome organized and what does it do?",{"text":117,"@type":113},"The eukaryotic ribosome has two subunits (60S and 40S) and translates the genetic code into functional proteins.",{"name":119,"@type":110,"acceptedAnswer":120},"Why is translational machinery considered important in gynecologic tumors?",{"text":121,"@type":113},"Dysregulation of ribosomal elements and translation factors is implicated in cancer development, progression, and metastasis, and adds an additional molecular layer in gynecologic cancers.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331585,1791481127,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":24,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":46,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":31,"preview_page_count":4},13056703019662,"https://ap-avatar.wpscdn.com/avatar/be000253a8e92610077?_k=1778726343310543188","Cancer and Metastasis Reviews (2025) 44:13  \n[https://doi.org/10.1007/s10555-024-10234-2](https://doi.org/10.1007/s10555-024-10234-2)  \nRibosomal rodeo: wrangling translational machinery in gynecologic tumors  \nKamil Filipek1 · Marianna Penzo1,2  \nReceived: 13 May 2024 / Accepted: 21 November 2024 / Published online: 2 December 2024 © The Author(s) 2024  \nAbstract  \nGynecologic cancers are a significant cause of morbidity and mortality among women worldwide. Despite advancementsin diagnosis and treatment, the molecular mechanisms underlying the development and progression of these cancers remain poorly understood. Recent studies have implicated translational machinery (ribosomal proteins (RPs) and translation factors (TFs)) as potential drivers of oncogenic processes in various cancer types, including gynecologic cancers. RPs are essential components of the ribosome, which is responsible for protein synthesis. In this review paper, we aim to explore the role of translational machinery in gynecologic cancers. Specifically, we will investigate the potential mechanisms by which these components contribute to the oncogenic processes in these cancers and evaluate the feasibility of targeting RPs as a potential therapeutic strategy. By doing so, we hope to provide a broader view of the molecular pathogenesis of gynecologic cancersand highlight their potential as novel therapeutic targets for the management of these challenging diseases.  \nKeywords Ovarian cancer · Cervical cancer · Endometrial cancer · Ribosome · RPL · RPS  \n1 Introduction  \nThe translational machinery encompasses a complex system of cellular components responsible for protein synthesis, including ribosomes, messenger RNA (mRNA), transfer RNA,(tRNA), translational factors, and regulatory proteins [1] . The eukaryotic ribosome consists of two asymmetric subunits, large (60S) composed of 47 proteins and 3 types of rRNA (5S, 5.8S, and 28S) and small (40S) composed of 33 proteins and 18S rRNA [2, 3], and is responsible for translating the genetic code into functional proteins. The protein biosynthesis is a cyclic process that occurs in four phases—initiation, elongation, termination, and recycling. In the initiation phase, the initiation factors put mRNA together with the initiator Met-tRNA on a small subunit, and at the end of this phase, joining of a large subunit makes translationally active ribosomes [4] . In the elongation phase, eEF1A brings  \n* Marianna Penzo [marianna.penzo@unibo.it](marianna.penzo@unibo.it)  \n1 Department of Medical and Surgical Sciences, and Center for Applied Biomedical Research, Alma Mater Studiorum University of Bologna, Bologna, Italy  \n2 IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy  \nnew, adequate aa-tRNA to the A-site of the ribosome, leading to the formation of peptides. Then, eEF2 as a translocase pushes the ribosome onto mRNA exposing a new codon in the decoding center. Appearing of the stop codon in the decoding center causes the termination of protein synthesis and thenascent polypeptide is released. In the recycling phase, the ribosome undergoes splitting by eRF1, eRF3, and eABCE1, and the free subunits may enter the new translational cycle [4](Fig. 1) . Therefore, the fundamental role of the entire translational machinery is to synthesize proteins; however, over decades of research, this function has been further elucidated and expanded. Recent studies have highlighted that diversity in ribosome composition, referred to as ribosome heterogeneity and/or specialization, can influence translational efficiency and fidelity, impacting protein synthesis rate and accuracy [5] . It is now clear that any alternation in ribosomes’ composition can result in pathological development and malignancy [6] . The relationship between translational machinery and cancer is a topic of significant interest in current research. Dysregulation of the translational machinery, including ribosomes and TFs, has been implicated in various","cbCaihFlVyYVwYru","https://ap.wps.com/l/cbCaihFlVyYVwYru","pdf",3266473,"English","# Abstract\n# Keywords\n# 1 Introduction\n## Translational machinery and protein synthesis phases\n## Ribosome heterogeneity and cancer relevance\n## Dysregulation in gynecologic cancers","[{\"question\":\"What does “translational machinery” include in this review?\",\"answer\":\"It includes ribosomes, mRNA, tRNA, translational factors, and regulatory proteins responsible for protein synthesis.\"},{\"question\":\"How is the eukaryotic ribosome organized and what does it do?\",\"answer\":\"The eukaryotic ribosome has two subunits (60S and 40S) and translates the genetic code into functional proteins.\"},{\"question\":\"Why is translational machinery considered important in gynecologic tumors?\",\"answer\":\"Dysregulation of ribosomal elements and translation factors is implicated in cancer development, progression, and metastasis, and adds an additional molecular layer in gynecologic cancers.\"}]","Ribosomal rodeo - wrangling translational machinery in gynecologic tumors | PDF",1789994192]