[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-378018-105":3,"doc-detail-378018-en":81,"detail-sidebar-cat-0-en-105":99},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","rewired-metabolism-caused-by-the-oncogenic-deregulation-of-myc-as-an-attractive-therapeutic-target-in-cancers","Rewired Metabolism Caused by the Oncogenic Deregulation of MYC as an Attractive Therapeutic Target in Cancers","","MYC is a highly deregulated oncogene across multiple cancer pathways. As a node transcription factor, it coordinates key cellular programs, especially cell cycle and metabolism, in both physiological and pathological settings. Tumor growth drives extreme energy and nutrient demand, requiring metabolic reprogramming in which MYC is central. Its altered regulation supports hallmark processes such as the Warburg effect, while direct MYC targeting remains difficult due to toxicity. This review summarizes mechanisms of MYC deregulation and the therapeutic options that exploit MYC-driven metabolic vulnerabilities.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/rewired-metabolism-caused-by-the-oncogenic-deregulation-of-myc-as-an-attractive-therapeutic-target-in-cancers/378018/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/rewired-metabolism-caused-by-the-oncogenic-deregulation-of-myc-as-an-attractive-therapeutic-target-in-cancers/378018.png","ImageObject",300,407,{"name":42,"@type":43},"Sophia Brooks","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-03","2026-09-24",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",9,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What roles does MYC play in cancer metabolism?","Question",{"text":63,"@type":64},"MYC regulates diverse cellular processes, including cell cycle and metabolism, and its deregulation drives metabolic rewiring in tumor cells. It is linked to hallmark phenomena such as the Warburg effect.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Why is directly targeting MYC therapeutically challenging?",{"text":68,"@type":64},"Direct MYC targeting is considered difficult because MYC has relatively high toxicity. Therefore, understanding MYC regulatory mechanisms is essential for developing tumor-selective targeted therapies.",{"name":70,"@type":61,"acceptedAnswer":71},"What topics does this review cover about MYC deregulation and therapy?",{"text":72,"@type":64},"The review summarizes multiple forms of MYC oncogenic deregulation across DNA, transcriptional, and post-translational levels. It also reviews currently available and potentially attractive therapeutic options that exploit vulnerabilities created by MYC-driven metabolic rearrangements.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},378018,1790708688,{"code":4,"msg":82,"data":83},"success",{"doc_id":79,"user_id":84,"nickname":42,"user_avatar":85,"doc_module":4,"category_id":86,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":87,"file_id":88,"file_url":89,"file_type":90,"file_size":91,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":92,"language":93,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":94,"faqs":95,"seo_title":96,"seo_description":12,"update_tm":97,"read_time":98},962084925636,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d",7,"cells  \nReview  \nRewired Metabolism Caused by the Oncogenic Deregulation of MYC as an Attractive Therapeutic Target in Cancers  \nLaura V½zkeleti 1 and S¡ndor Spis¡k 2, *  \nCitation: Vízkeleti, L.; Spisák, S. Rewired Metabolism Caused by the Oncogenic Deregulation of MYC asan Attractive Therapeutic Target in Cancers. Cells 2023, 12, 1745 . [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)cells12131745  \nAcademic Editor: Edward  \nV. Prochownik  \nReceived: 10 April 2023  \nRevised: 20 June 2023  \nAccepted: 20 June 2023  \nPublished: 29 June 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Department of Bioinformatics, Faculty of Medicine, Semmelweis University, 1094 Budapest, Hungary; [vizkeleti.laura@med.semmelweis-univ.hu](vizkeleti.laura@med.semmelweis-univ.hu)  \n2 Institute of Enzymology, Research Centre for Natural Sciences, Eötvös Lor¡nd Research Network, 1117 Budapest, Hungary  \n* Correspondence: [spisak.sandor@ttk.hu](spisak.sandor@ttk.hu)  \nAbstract: MYC is one of the most deregulated oncogenes on multiple levels in cancer. As a node transcription factor, MYC plays a diverse regulatory role in many cellular processes, including cell cycle and metabolism, both in physiological and pathological conditions. The relentless growth and proliferation of tumor cells lead to an insatiable demand for energy and nutrients, which requires therewiring of cellular metabolism. As MYC can orchestrate all aspects of cellular metabolism, its altered regulation plays a central role in these processes, such as the Warburg effect, and is a well-established hallmark of cancer development. However, our current knowledge of MYC suggests that its spatialand concentration-dependent contribution to tumorigenesis depends more on changes in the global or relative expression of target genes. As the direct targeting of MYC is proven to be challenging due to its relatively high toxicity, understanding its underlying regulatory mechanisms is essential for the development of tumor-selective targeted therapies. The aim of this review is to comprehensively summarize the diverse forms of MYC oncogenic deregulation, including DNA-, transcriptional-and post-translational level alterations, and their consequences for cellular metabolism. Furthermore, we also review the currently available and potentially attractive therapeutic options that exploit the vulnerability arising from the metabolic rearrangement of MYC-driven tumors.  \nKeywords: protooncogene; MYC deregulation; altered cellular metabolism; therapeutic targets  \n1. Introduction  \nThe MYC is a family of regulator and proto-oncogenes coding bHLHZip-type transcription factors (TFs) that have a broad range of effects on cellular processes. These include ribosome biogenesis, cell cycle, apoptosis, metabolism, and distant metastatic progress in malignant conditions [1,2]. The family consists of three human genes, including c-MYC, and the first of these, which has a sequence homology with the viral gene v-myc, was discovered 40 years ago [3] . In humans, the MYC proto-oncogene is located at the 8q24.21 locus. In normal conditions, it is considered to regulate the expression of approximately 15% of all genes through binding to specific enhancer box sequences, the E-boxes [4] . MYC regulates transcription through obligatory dimerization with another bHLHZip-type transcription factor, MAX [5,6] . Generally, it promotes gene expression via the release of blocked RNA polymerases, which is significantly influenced by the chromatin accessibility at target sites. Therefore, MYC is a selective amplifier, a common upstream TF that is dependent on cooperation with other TFs (such ","cbCaijA9wC05ZwzV","https://ap.wps.com/l/cbCaijA9wC05ZwzV","pdf",1558176,25,"English","# Abstract\n# 1. Introduction\n# 2. Overview of MYC Regulation in the Physiological State\n## 2.1. Regulation at the Transcriptional Level","[{\"question\":\"What roles does MYC play in cancer metabolism?\",\"answer\":\"MYC regulates diverse cellular processes, including cell cycle and metabolism, and its deregulation drives metabolic rewiring in tumor cells. It is linked to hallmark phenomena such as the Warburg effect.\"},{\"question\":\"Why is directly targeting MYC therapeutically challenging?\",\"answer\":\"Direct MYC targeting is considered difficult because MYC has relatively high toxicity. Therefore, understanding MYC regulatory mechanisms is essential for developing tumor-selective targeted therapies.\"},{\"question\":\"What topics does this review cover about MYC deregulation and therapy?\",\"answer\":\"The review summarizes multiple forms of MYC oncogenic deregulation across DNA, transcriptional, and post-translational levels. It also reviews currently available and potentially attractive therapeutic options that exploit vulnerabilities created by MYC-driven metabolic rearrangements.\"}]","Rewired Metabolism Caused by the Oncogenic Deregulation of MYC as an Attractive Therapeutic Target in Cancers | PDF",1790228040,63,{"code":4,"msg":82,"data":100},[101,105,109,113,118,123,126,131,135,138,142],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":106,"show_sort_weight":107,"slug":108},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":110,"show_sort_weight":111,"slug":112},"Exam",70,"exam",{"id":114,"doc_module":4,"doc_module_name":25,"category_name":115,"show_sort_weight":116,"slug":117},5,"Comic",60,"comic",{"id":119,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":121,"slug":122},6,"Technology",50,"technology",{"id":86,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":124,"slug":125},40,"healthcare",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":129,"slug":130},8,"Research & Report",30,"research-report",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":132,"show_sort_weight":133,"slug":134},"Religion & Spirituality",20,"religion-spirituality",{"id":133,"doc_module":4,"doc_module_name":25,"category_name":136,"show_sort_weight":133,"slug":137},"World Cup","world-cup",{"id":139,"doc_module":4,"doc_module_name":25,"category_name":140,"show_sort_weight":139,"slug":141},10,"Lifestyle","lifestyle",{"id":143,"doc_module":4,"doc_module_name":25,"category_name":144,"show_sort_weight":114,"slug":145},19,"General","general"]