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METHODS: Tumor tissues and clinical data from 101 gastric cancer patients were analyzed using immunohistochemistry, Cox regression, and a nomogram with ROC, calibration, and C-index assessment, plus Kaplan-Meier survival stratification. RESULTS and CONCLUSION: High NPAS2 expression correlated with advanced clinicopathologic features and worse overall survival, supporting NPAS2 as an independent prognostic biomarker.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/retrospective-study-high-expression-of-the-circadian-clock-gene-npas2-associated-with-progression-and-poor-prognosis-of-gastric-cancer/379000/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/retrospective-study-high-expression-of-the-circadian-clock-gene-npas2-associated-with-progression-and-poor-prognosis-of-gastric-cancer/379000.png","ImageObject",300,407,{"name":42,"@type":43},"\tJames","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-28","2026-09-24",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",9,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is the main purpose of this retrospective study?","Question",{"text":63,"@type":64},"To explore the relationship between NPAS2 expression and survival prognosis in gastric cancer patients after surgical resection.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How was NPAS2 expression measured and analyzed?",{"text":68,"@type":64},"NPAS2 protein expression was detected in tumor and adjacent tissues using immunohistochemical staining, followed by univariate and multivariate Cox regression and construction of a nomogram prediction model.",{"name":70,"@type":61,"acceptedAnswer":71},"What did the study find about NPAS2 and patient outcomes?",{"text":72,"@type":64},"High NPAS2 expression was associated with advanced clinicopathologic features and significantly shorter overall survival, with NPAS2 identified as an independent prognostic 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[https://www.f6publishing.com](https://www.f6publishing.com) World J Gastroenterol 2023 June 21; 29(23): 3645-3657  \nDOI: 10.3748/wjg.v29.i23.3645 ISSN 1007-9327 (print) ISSN 2219-2840 (online)  \nORIGINAL ARTICLE  \nRetrospective Study  \nHigh expression of the circadian clock gene NPAS2 is associated with progression and poor prognosis of gastric cancer: A singlecenter study  \nXiao-Meng Cao, Wen-Di Kang, Tian-Hong Xia, Shao-Bin Yuan, Chang-An Guo, Wen-Jie Wang, Hong-Bin Liu  \nSpecialty type: Gastroenterology and hepatology  \nProvenance and peer review:  \nUnsolicited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s scientific quality classification  \nGrade A (Excellent): 0  \nGrade B (Very good): 0  \nGrade C (Good): C, C, C, C  \nGrade D (Fair): D  \nGrade E (Poor): 0  \nP-Reviewer: Benna C, Italy; Papadia C, United Kingdom; Qin SS, China  \nReceived: February 9, 2023  \nPeer-review started: February 9, 2023  \nFirst decision: March 9, 2023  \nRevised: March 16, 2023  \nAccepted: May 4, 2023  \nArticle in press: May 4, 2023  \nPublished online: June 21, 2023  \nXiao-Meng Cao, Department of General Surgery, Gansu Provincial Hospital of TCM, Lanzhou 730050, Gansu Province, China  \nXiao-Meng Cao, Shao-Bin Yuan, The First Clinical Medical College, Gansu University of Chinese Medicine, Lanzhou 730030, Gansu Province, China  \nWen-Di Kang, Department of Interventional Therapy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China  \nTian-Hong Xia, Clinical Medicine College, Ningxia Medical University, Clinical Medicine college, Ningxia Medical University, Yinchuan 750004, Ningxia Hui Autonomous Region, China  \nChang-An Guo, Department of Emergency, Lanzhou University Second Hospital, Lanzhou 730030, Gansu Province, China  \nWen-Jie Wang, Department of General Surgery, Lanzhou University Second Hospital, Lanzhou 730030, Gansu Province, China  \nHong-Bin Liu, Department of General Surgery, The 940th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army, Lanzhou 730050, Gansu Province, China  \nCorresponding author: Hong-Bin Liu, MD, Professor, Department of General Surgery, The 940th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army, No. 333 Nanbinhe Road, Qilihe District, Lanzhou 730050, Gansu Province, China.  \n[1554153823@qq.com](1554153823@qq.com)  \nAbstract  \nBACKGROUND  \nThe prognostic assessment of patients after surgical resection of gastric cancer (GC) patients is critical. However, the role of the circadian clock gene NPAS2 expression in GC remains unknown.  \nAIM  \nTo explore the relationship between NPAS2 and the survival prognosis of GC  \n WJG  [https://www.wjgnet.com](https://www.wjgnet.com) 3645 June 21, 2023  Volume 29  Issue 23   \nCao XM et al. NPAS2 is a prognostic biomarker for GC  \npatients and clarify its role in evaluating GC prognosis.  \nMETHODS  \nThe tumor tissues and clinical data of 101 patients with GC were collected retrospectively. Immunohistochemical staining (IHC) was used to detect the expression of NPAS2 protein in GC and adjacent tissues. Univariate and multivariate Cox regression analysis was used to determine the independent prognostic factors of GC, and a nomogram prediction model was established. The receiver operating characteristic (ROC) curve, the ROC area under the curve, the calibration curve, and C-index were used to evaluate the predictive effectiveness of the model. Kaplan Meier analysis was used to compare the risk stratification of subgroups according to the median score in the nomogram model of each patient.  \nRESULTS  \nMicroarray IHC analysis showed that the positive rate of NPAS2 protein expression in GC tissues was 65.35%, which was significantly higher than 30.69% in adjacent tissues. The ","cbCaibctkz6185rt","https://ap.wps.com/l/cbCaibctkz6185rt","pdf",12991599,14,"English","# Background\n# Aim\n# Methods\n# Results\n# Conclusion","[{\"question\":\"What is the main purpose of this retrospective study?\",\"answer\":\"To explore the relationship between NPAS2 expression and survival prognosis in gastric cancer patients after surgical resection.\"},{\"question\":\"How was NPAS2 expression measured and analyzed?\",\"answer\":\"NPAS2 protein expression was detected in tumor and adjacent tissues using immunohistochemical staining, followed by univariate and multivariate Cox regression and construction of a nomogram prediction model.\"},{\"question\":\"What did the study find about NPAS2 and patient outcomes?\",\"answer\":\"High NPAS2 expression was associated with advanced clinicopathologic features and significantly shorter overall survival, with NPAS2 identified as an independent prognostic factor.\"}]","Retrospective Study - High expression of the circadian clock gene NPAS2 associated with progression and poor prognosis of gastric cancer | PDF",1790233593,35]