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Signed documentation from all authors was not received, so the journal editorial decision was to retract the work. Original article reference: Oncotarget 2016; 7:66989–67003.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/retraction-retraction-microrna-21-promotes-tgf-1-induced-epithelial-mesenchymal-transition-in-gastric-cancer-through-up-regulating-pten-expression/454810/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/retraction-retraction-microrna-21-promotes-tgf-1-induced-epithelial-mesenchymal-transition-in-gastric-cancer-through-up-regulating-pten-expression/454810.png","ImageObject",300,407,{"name":92,"@type":93},"Nguyễn Văn Học","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-07","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":14},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Which article is being retracted?","Question",{"text":112,"@type":113},"The retracted work is titled “MicroRNA-21 promotes TGF-β1-induced epithelial-mesenchymal transition in gastric cancer through up-regulating PTEN expression” in Oncotarget.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What major problems were identified after the 2020 correction?",{"text":117,"@type":113},"The notice reports authenticity concerns in Figures 5 and 6, identical ‘Blank’ and ‘Negative Control’ images in Figure 11B (48 hr row), and duplicated Western blot and immunohistochemistry images across multiple figures and unrelated papers.",{"name":119,"@type":110,"acceptedAnswer":120},"What was the final editorial outcome?",{"text":121,"@type":113},"Requests for signed documentation were sent to all authors but no signatures were received; therefore, Oncotarget retracted the paper.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},454810,1790741414,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":129,"read_time":81,"preview_page_count":4},1374402739827,"https://ap-avatar.wpscdn.com/avatar/14000c97e7351f1a627?x-image-process=image/resize,m_fixed,w_180,h_180&k=1787885694763230660","[www.oncotarget.com](www.oncotarget.com) Oncotarget, 2025, Vol. 16, pp: 863-863  \nRetraction  \nRetraction: MicroRNA-21 promotes TGF-β1-induced epithelialmesenchymal transition in gastric cancer through up-regulating PTEN expression  \nChang Li 1, Lei Song2, Zhuo Zhang3, Xiao-Xue Bai4, Ming-Fu Cui 1 and Lian-Jun Ma5 1 Department of Gastrointestinal Surgery, China-Japan Union Hospital of Jilin University, Changchun, 130000, Jilin, P. R. China  \n2 Department of Respiratory Medicine, The First Hospital of Jilin University, Changchun, 130000, Jilin, P. R. China 3 Department of Orthopaedics, China-Japan Union Hospital of Jilin University, Changchun, 130000, Jilin, P. R. China 4 Department of Cadre Ward, The First Hospital of Jilin University, Changchun, 130000, Jilin, P. R. China 5 Department of Endoscopics, China-Japan Union Hospital of Jilin University, Changchun, 130000, Jilin, P. R. China  \nPublished: Deceember 31, 2025  \nCopyright: © 2025 Li et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4. 0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.  \nThis article has been retracted: Oncotarget has completed its investigation of this paper. After a correction notice was published for this article in 2020, correcting an image in Figure 4D, several additional problems were identified. Specifically, Figures 5 and 6 have a lack of background noise, questioning the authenticity of the data. Also, the ‘Blank’ and ‘Negative Control’ images in the ‘48 hr’ row of Figure 11B are identical. In Figure 10B, a western blot duplicates one found in Figure 4J of [1], which has since been retracted. Figure 9B duplicates a western blot also shown in Figure 6G of [2], also retracted. Immunohistochemistry images in Figure 2C (P-Akt) and 2E (Akt) were reproduced in the unrelated papers [3, 4], respectively. And b-actin western blot in Figure 5C appeared in the later published article [5] . Requests for signed documentation to confirm the retraction were sent to all authors, but no signatures have been received. In light of these findings, the editorial decision was made to retract this paper.  \nOriginal article: Oncotarget. 2016; 7:66989–67003. [https://doi.org/10.18632/oncotarget.11888](https://doi.org/10.18632/oncotarget.11888)  \nREFERENCES  \n1. Qiu Y, Cao X, Liu L, Cao X, Yuan Q, Li X, Cui Y, Xu C, Zou C, Ren K, Cao J. Modulation of MnSOD and FoxM1 Is Involved in Invasion and EMT Suppression by Isovitexin in Hepatocellular Carcinoma Cells. Cancer Manag Res. 2020; 12:5759–71. [https://](https://)[ ](https://)[doi.org/10.2147/CMAR.S245283](doi.org/10.2147/CMAR.S245283). [PubMed]. Retraction in: Cancer Manag Res. 2022; 14:1473–74. [https://doi.org/10.2147/CMAR](https://doi.org/10.2147/CMAR). S370617 . [PubMed]  \n2. Liu F, Yuan Q, Cao X, Zhang J, Cao J, Zhang J, Xia L. Isovitexin Suppresses Stemness of Lung Cancer Stem-Like Cells through Blockage of MnSOD/CaMKII/AMPK Signaling and Glycolysis Inhibition. Biomed Res Int. 2021; 2021:9972057. [https://doi](https://doi). org/10.1155/2021/9972057. [PubMed]. Retraction in: Biomed Res Int. 2024; 2024:9802384. [https://doi.org/10.1155/2024/9802384](https://doi.org/10.1155/2024/9802384) .[PubMed]  \n3. Han MY, Nie JW, Li YY, Zhu YZ, Wu G. Downregulation of NGAL is Required for the Inhibition of Proliferation and the Promotion of Apoptosis of Human Gastric Cancer MGC-803 Cells. Cell Physiol Biochem. 2018; 50:694–705. [https://doi.org/10.1159/000494236](https://doi.org/10.1159/000494236) .[PubMed]. Retraction in: Cell Physiol Biochem. 2021; 55:673. [https://doi.org/10.33594/000000463](https://doi.org/10.33594/000000463). [PubMed]  \n4. Ao R, Guan L, Wang Y, Wang JN. Silencing of COL1A2, COL6A3, and THBS2 inhibits gastric cancer cell proliferation, migration, and invasion while promoting apoptosis through the PI3k-Akt signaling pathway. J Cell Biochem. 2018; 119:4420–34. [","cbCaijtdyk4YMqVW","https://ap.wps.com/l/cbCaijtdyk4YMqVW","pdf",236889,"English","# Retraction notice\n## Reasons for retraction and identified image/data issues\n## Editorial decision and author responses\n## Original article citation","[{\"question\":\"Which article is being retracted?\",\"answer\":\"The retracted work is titled “MicroRNA-21 promotes TGF-β1-induced epithelial-mesenchymal transition in gastric cancer through up-regulating PTEN expression” in Oncotarget.\"},{\"question\":\"What major problems were identified after the 2020 correction?\",\"answer\":\"The notice reports authenticity concerns in Figures 5 and 6, identical ‘Blank’ and ‘Negative Control’ images in Figure 11B (48 hr row), and duplicated Western blot and immunohistochemistry images across multiple figures and unrelated papers.\"},{\"question\":\"What was the final editorial outcome?\",\"answer\":\"Requests for signed documentation were sent to all authors but no signatures were received; therefore, Oncotarget retracted the paper.\"}]","Retraction - Retraction - MicroRNA-21 promotes TGF-β1-induced epithelial-mesenchymal transition in gastric cancer through up-regulating PTEN expression | PDF"]