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The retraction reflects unresolved issues with the provided underlying image data and overall reliability of the reported results.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/retraction-molecular-and-cellular-mechanisms-of-cigarette-smoke-induced-myocardial-injury-prevention-by-vitamin-c/444982/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/retraction-molecular-and-cellular-mechanisms-of-cigarette-smoke-induced-myocardial-injury-prevention-by-vitamin-c/444982.png","ImageObject",300,407,{"name":92,"@type":93},"jay","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-30","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":14},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What triggered the retraction of the PLOS One article?","Question",{"text":112,"@type":113},"The PLOS One Editors reported concerns about the results presented in Figs 2, 4, and 6, including similarities and overlaps in specific western blot and related panels, along with unresolved questions about data integrity.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which figure elements were specifically called into question?",{"text":117,"@type":113},"Concerns included marker lane similarity across Fig 2A, Fig 2B, Fig 6B, Fig 6C, and Fig 4A/Fig 4B, plus partial overlap between specified panels in Fig 2C and Fig 4E under different conditions.",{"name":119,"@type":110,"acceptedAnswer":120},"Did the authors agree with the retraction decision?",{"text":121,"@type":113},"AD did not agree with the retraction, while ND, AG, SD, and DJC either did not respond directly or could not be reached; IBC was deceased.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},444982,1790765238,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":81},3985747858866,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","OPEN ACCESS  \nCitation: The PLOS One Editors (2026)  \nRetraction: Molecular and cellular mechanisms of cigarette smoke-induced myocardial injury: Prevention by Vitamin C. PLoS One 21(1): e0340142. [https://doi.org/10.1371/journal](https://doi.org/10.1371/journal). pone.0340142  \nPublished: January 6, 2026  \nCopyright: © 2026 The PLOS One Editors. This is an open access article distributed under the terms of the Creative Commons Attribution  License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.  \nRETRACTION  \nRetraction: Molecular and cellular mechanisms of cigarette smoke-induced myocardial injury:  \nPrevention by Vitamin C  \nThe PLOS One Editors  \nAfter this article [ 1] was published, concerns were raised regarding results presented in Figs 2, 4 and 6.  \nSpecifically:  \n• In the following western blot panels, the marker “M” lanes appear similar: Fig 2A, Fig 2B, Fig 6B, Fig 6C in [ 1], and Fig 4A and Fig 4B in [2], retracted in [3]  \n• The following panels appear to partially overlap:  \n◦ Fig 2C CS 2 Weeks 15mg vit C DAPI and Fig 2C 6 Weeks CS 15mg vit C DAPI  \n◦ Fig 4E AIR 8 Weeks 0 .5mg vit C TUNELand Fig 4E AIR 8 Weeks 15mg vit C TUNEL  \nRegarding the marker lanes in [ 1] and [2], the first author stated these lanes are similar because the experiments were run under similar percentage SDS-PAGE and the same voltage, and the protein marker is shown for reference only. They provided data underlying Figs 2A, 2B, 6B, and 6C, however editorial review raised additional concerns about the integrity of the underlying data provided.  \nRegarding Fig 2C, the first author disagreed that these panels appear similar. Regarding Fig 4E, they agreed with the concerns identified for the AIR 8 Weeks 0.5 mg vit C TUNEL and Fig 4E AIR 8 Weeks 15 mg vit C TUNEL panels. The first author stated these panels should be different. The underlying image data provided did not resolve these concerns and instead raised further concerns about the overall data handling.  \nIn light of the above concerns that question the reliability of the reliability of the reported results, the PLOS One Editors retract this article.  \nAD did not agree with the retraction. ND, AG, SD, and DJC either did not respond directly or could not be reached. IBC is deceased.  \nReferences  \n1. DasA, Dey N, GhoshA, Das S, Chattopadhyay DJ, Chatterjee IB. RETRACTED: Molecular and cellular mechanisms of cigarette smoke-induced myocardial injury: prevention by vitamin C. PLoS One. 2012;7(9):e44151 . [https://doi.org/10.1371/journal.pone.0044151](https://doi.org/10.1371/journal.pone.0044151) PMID: 22970172  \n2. DasA, Dey N, GhoshA, Das T, Chatterjee IB. RETRACTED: NAD(P)H: quinone oxidoreductase 1 deficiency conjoint with marginal vitamin C deficiency causes cigarette smoke induced myelodysplastic syndromes. PLoS One. 2011;6(5):e20590 . [https://doi.org/10.1371/journal.pone.0020590](https://doi.org/10.1371/journal.pone.0020590 PMID:)[ PMID:](https://doi.org/10.1371/journal.pone.0020590 PMID:) 21655231  \n3. The PLOS One Editors. NAD(P)H: Quinone oxidoreductase 1 deficiency conjoint with marginal vitamin C deficiency causes cigarette smoke induced myelodysplastic syndromes. PLoS One. 2026;21(1):e0340144 . [https://doi.org/10.1371/journal.pone.0340144](https://doi.org/10.1371/journal.pone.0340144)  \nPLOS One | [https://doi.org/10.1371/journal.pone.0340142](https://doi.org/10.1371/journal.pone.0340142) January 6, 2026 1 / 1","cbCaihwx12TjMSG4","https://ap.wps.com/l/cbCaihwx12TjMSG4","pdf",142456,"English","# RETRACTION\n## Article and publication details\n## Editors’ concerns (figures and panels)\n## Authors’ responses\n## Retraction statement and parties involved\n## References","[{\"question\":\"What triggered the retraction of the PLOS One article?\",\"answer\":\"The PLOS One Editors reported concerns about the results presented in Figs 2, 4, and 6, including similarities and overlaps in specific western blot and related panels, along with unresolved questions about data integrity.\"},{\"question\":\"Which figure elements were specifically called into question?\",\"answer\":\"Concerns included marker lane similarity across Fig 2A, Fig 2B, Fig 6B, Fig 6C, and Fig 4A/Fig 4B, plus partial overlap between specified panels in Fig 2C and Fig 4E under different conditions.\"},{\"question\":\"Did the authors agree with the retraction decision?\",\"answer\":\"AD did not agree with the retraction, while ND, AG, SD, and DJC either did not respond directly or could not be reached; IBC was deceased.\"}]","Retraction - Molecular and cellular mechanisms of cigarette smoke-induced myocardial injury - Prevention by Vitamin C | PDF",1790709980]