[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-detail-364400-en":59,"doc-seo-364400-105":81},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":5,"data":60},{"doc_id":61,"user_id":62,"nickname":63,"user_avatar":64,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":66,"doc_content":67,"file_id":68,"file_url":69,"file_type":70,"file_size":71,"view_count":72,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":73,"language_code":74,"site_id":75,"html_lang":74,"table_of_contents":76,"faqs":77,"seo_title":78,"seo_description":66,"update_tm":79,"read_time":80},364400,4398048949847,"Eliana","https://ap-avatar.wpscdn.com/avatar/400002536579ef2da7f?_k=1778318612642679267","Rethinking the rise of early-onset gastrointestinal cancers - a call to action","Since the early 1990s, gastrointestinal cancer diagnoses have risen sharply among patients under age 50, with the largest increase in early-onset colorectal cancer, particularly left-sided colon and rectal cancers. Growth in gastric, pancreatic, and other gastrointestinal cancer diagnoses has further fueled the trend. A multidisciplinary Think Tank proposes a coordinated research strategy structured around epidemiology and environment, the microbiome, and survivorship, emphasizing biospecimen use, standardized microbiome workflows, mechanistic follow-up, and survivorship-focused needs.","JNCI Cancer Spectrum, 2025, 9(1), pkaf002  \n[https://doi.org/10.1093/jncics/pkaf002](https://doi.org/10.1093/jncics/pkaf002)  \nAdvance Access Publication Date: January 15, 2025  \nCommentary  \nRethinking the rise of early-onset gastrointestinal cancers: a call to action  \nBenjamin A. Weinberg , MD􀀃,1 , Caitlin C. Murphy , PhD, MPH2, David R. Freyer , DO, MS3,4,  \nK. Leigh Greathouse , PhD, MPH, MS, RD5, Jan K. Blancato, PhD6, Elena M. Stoffel, MD, MPH7, Julia L. Drewes, PhD8,  \nAnne Blaes , MD, MS9, John M. Salsman , PhD10, Y. Nancy You, MD, MHSc11, Hannah Arem , PhD12, Reetu Mukherji , MD1, Priyanka Kanth , MD, MS13, Xin Hu , PhD14, Anne Fabrizio, MD15, Marion L. Hartley , PhD1, Marios Giannakis , MD, PhD16, John L. Marshall , MD1  \n1Ruesch Center for the Cure of Gastrointestinal Cancers, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20007, United States  \n2Department of Health Promotion & Behavioral Sciences, UTHealth Houston School of Public Health, Houston, TX 77030, United States  \n3Departments of Pediatrics, Medicine, and Population & Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA 90032, United States  \n4USC Norris Comprehensive Cancer Center and Children’s Hospital Los Angeles, Los Angeles, CA 90089, United States  \n5Department of Human Sciences and Design, Baylor University, Waco, TX 76706, United States 6Department of Oncology, Georgetown University, Washington, DC 20007, United States  \n7Department of Internal Medicine, University of Michigan, Rogel Cancer Center, Ann Arbor, MI 48109, United States  \n8Department of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States 9Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, United States  \n10Wake Forest University School of Medicine & Atrium Health Wake Forest Baptist Comprehensive Cancer Center, Winston Salem, NC 27157, United States 11Department of Colon and Rectal Surgery, University of Texas MD Anderson Cancer Center, Houston, TX 78701, United States  \n12Healthcare Delivery Research, MedStar Health Research Institute, Washington, DC 20010, United States  \n13Division of Gastroenterology, MedStar Georgetown University Hospital, Lombardi Comprehensive Cancer Center, Washington, DC 20007, United States 14Gangarosa Department of Environmental Health, Emory University Rollins School of Public Health, Atlanta, GA 30329, United States  \n15Division of Colon & Rectal Surgery, MedStar Georgetown University Hospital, Washington, DC 20007, United States 16Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, United States  \n􀀃 Corresponding author: Benjamin A. Weinberg, MD, Ruesch Center for the Cure of Gastrointestinal Cancers, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, 3800 Reservoir Rd. NW, Washington, DC 20007, United States ([Benjamin.A.Weinberg@gunet.georgetown.edu](Benjamin.A.Weinberg@gunet.georgetown.edu)) .  \nAuthor Contributions: M. Giannakis and J. L. Marshall are co-senior authors of this work.  \nAbstract  \nSince the early 1990s, there has been a dramatic rise in gastrointestinal cancers diagnosed in patients under age 50 for reasons that remain poorly understood. The most significant change has been the increase in incidence rates of early-onset colorectal cancer, especially rates of left-sided colon and rectal cancers. Increases in gastric, pancreatic, and other gastrointestinal cancer diagnoseshave further contributed to this trend. We formed a multidisciplinary Think Tank to develop a strategic, coordinated approach to studying early-onset gastrointestinal cancers. This area of research is challenging given multifactorial etiologies. We focused on epidemiology and the environment, the microbiome, and survivorship as key pillars to structure a research framework. We advocate a comprehensive strategy to (1) use existing biospecimens","cbCaianUtWlqiVpt","https://ap.wps.com/l/cbCaianUtWlqiVpt","pdf",864072,13,"English","en",105,"# Introduction\n## Multidisciplinary research framework\n## Key recommendations","[{\"question\":\"What major change has driven the rise of early-onset gastrointestinal cancers?\",\"answer\":\"The most significant change is the increase in incidence rates of early-onset colorectal cancer, especially left-sided colon and rectal cancers.\"},{\"question\":\"Why is understanding the causes of EOGIC challenging?\",\"answer\":\"The document notes that EOGIC has multifactorial etiologies and that research programs have only partially clarified potential causes.\"},{\"question\":\"What are the core pillars and actions proposed by the Think Tank?\",\"answer\":\"The framework focuses on epidemiology/environment, the microbiome, and survivorship. It advocates using existing longitudinal biospecimens, standardizing specimen collection and analyses, prioritizing mechanistic studies, and addressing survivorship needs for this young population.\"}]","Rethinking the rise of early-onset gastrointestinal cancers - a call to action | PDF",1790157423,23,{"code":4,"msg":82,"data":83},"ok",{"site_id":75,"language":74,"slug":84,"title":65,"keywords":85,"description":66,"schema_data":86,"social_meta":140,"head_meta":142,"extra_data":144,"updated_unix":145},"rethinking-the-rise-of-early-onset-gastrointestinal-cancers-a-call-to-action","",{"@graph":87,"@context":139},[88,102,122],{"@type":89,"itemListElement":90},"BreadcrumbList",[91,95,97,100],{"item":92,"name":93,"@type":94,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":96,"name":9,"@type":94,"position":14},"https://docshare.wps.com/document/",{"item":98,"name":35,"@type":94,"position":99},"https://docshare.wps.com/document/healthcare/",3,{"item":101,"name":65,"@type":94,"position":19},"https://docshare.wps.com/document/rethinking-the-rise-of-early-onset-gastrointestinal-cancers-a-call-to-action/364400/",{"url":101,"name":65,"@type":103,"image":104,"author":109,"headline":65,"publisher":111,"fileFormat":114,"inLanguage":74,"description":66,"dateModified":115,"datePublished":116,"encodingFormat":114,"isAccessibleForFree":117,"interactionStatistic":118},"DigitalDocument",{"url":105,"@type":106,"width":107,"height":108},"https://docshare.wps.com/thumbnails/rethinking-the-rise-of-early-onset-gastrointestinal-cancers-a-call-to-action/364400.png","ImageObject",300,407,{"name":63,"@type":110},"Person",{"url":92,"name":112,"@type":113},"DocShare","Organization","application/pdf","2026-10-29","2026-09-23",true,{"@type":119,"interactionType":120,"userInteractionCount":72},"InteractionCounter",{"@type":121},"ViewAction",{"@type":123,"mainEntity":124},"FAQPage",[125,131,135],{"name":126,"@type":127,"acceptedAnswer":128},"What major change has driven the rise of early-onset gastrointestinal cancers?","Question",{"text":129,"@type":130},"The most significant change is the increase in incidence rates of early-onset colorectal cancer, especially left-sided colon and rectal cancers.","Answer",{"name":132,"@type":127,"acceptedAnswer":133},"Why is understanding the causes of EOGIC challenging?",{"text":134,"@type":130},"The document notes that EOGIC has multifactorial etiologies and that research programs have only partially clarified potential causes.",{"name":136,"@type":127,"acceptedAnswer":137},"What are the core pillars and actions proposed by the Think Tank?",{"text":138,"@type":130},"The framework focuses on epidemiology/environment, the microbiome, and survivorship. It advocates using existing longitudinal biospecimens, standardizing specimen collection and analyses, prioritizing mechanistic studies, and addressing survivorship needs for this young population.","https://schema.org",{"og:url":101,"og:type":141,"og:title":65,"og:site_name":112,"og:description":66},"article",{"robots":143,"canonical":101},"index,follow",{"doc_id":61,"site_id":75},1790194926]