[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-373137-105":59,"doc-detail-373137-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","retained-rim-enhancement-in-mucinous-breast-cancer-suggests-aggressive-biology-a-case-report","Retained Rim Enhancement in Mucinous Breast Cancer Suggests Aggressive Biology - A Case Report","","A 44-year-old premenopausal woman was evaluated for a rapidly enlarging left breast mass. Imaging showed a 14 mm oval lesion with distinct borders and characteristic ultrasound and MRI findings, including early and retained rim enhancement on subtraction MRI. Core needle biopsy identified mucinous breast cancer with abundant mucus and atypical papillary cells. Surgery included breast-conserving resection and sentinel node biopsy; pathology demonstrated ring-distributed cancer cells, sparse tumor cells in the center with thick fibrous septa, and no nodal metastasis. Immunostaining revealed hormone receptor positivity, HER2 equivocation, and a high Ki-67 labeling index, suggesting retained rim enhancement may reflect aggressive biology.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/retained-rim-enhancement-in-mucinous-breast-cancer-suggests-aggressive-biology-a-case-report/373137/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/retained-rim-enhancement-in-mucinous-breast-cancer-suggests-aggressive-biology-a-case-report/373137.png","ImageObject",300,407,{"name":92,"@type":93},"River Wang","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What key MRI feature was central to this case report?","Question",{"text":112,"@type":113},"Subtraction MRI demonstrated early and retained rim enhancement patterns of the tumor.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was the diagnosis of mucinous breast cancer established?",{"text":117,"@type":113},"Core needle biopsy showed atypical papillary cells with abundant mucus, leading to the diagnosis.",{"name":119,"@type":110,"acceptedAnswer":120},"What pathological and immunostaining findings supported aggressive biology?",{"text":121,"@type":113},"Post-operative pathology showed ring-distributed tumor cells with extremely sparse cells in the mass center and thick fibrous septa, with high Ki-67 (50%) and estrogen/progesterone receptor positivity and HER2 equivocation.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},373137,1790259174,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":29,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},1099514067438,"https://ap-avatar.wpscdn.com/avatar/100002539ee87300030?x-image-process=image/resize,m_fixed,w_180,h_180&k=1780474512215547542","Review began 02/12/2025  \nReview ended 02/20/2025  \nPublished 02/25/2025  \n© Copyright 2025  \nTakahashi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CCBY 4.0. , which permits unrestricted use , distribution , and reproduction in any medium , provided the original author and source are credited.  \nDOI: 10.7759/cureus.79644  \nOpen Access Case Report  \nRetained Rim Enhancement in Mucinous Breast Cancer Suggests Aggressive Biology: A Case Report  \nHarumasa Takahashi 1 , Shoji Oura 1  \n1. Department of Surgery, Kishiwada Tokushukai Hospital, Kishiwada, JPN Corresponding author: Shoji Oura, [shouji.oura@tokushukai.jp](shouji.oura@tokushukai.jp)  \nAbstract  \nA 44-year-old premenopausal woman was referred to our hospital for a detailed examination of her left rapidly growing breast mass. Mammography only showed focal asymmetric density. Ultrasound showed a 14 mm oval mass with distinct borders, a high depth/width rate of 0 .79, numerous punctate echogenic foci against background low echoes, and slightly enhanced posterior echoes. Magnetic resonance imaging (MRI) of the mass showed low signal intensity on T1-weighted images and high signal intensity with a slightly low signal intensity area in the mass center on fat-suppressed T2-weighted images. Subtraction MRI depicted early and retained rim enhancement patterns. The patient underwent a core needle biopsy of the breast mass. Pathological study showed that the tumor had atypical cells growing in a papillary fashion with abundant mucus, leading to the diagnosis of mucinous breast cancer. The patient, therefore, underwent breast-conserving surgery and sentinel node biopsy. A post-operative pathological study showed that the tumor had cancer cells mainly distributed in a ring fashion and extremely sparse cancer cells with thick fibrous septa in the mass center. Immunostaining showed that the mucinous breast cancer had estrogen and progesterone receptor positivities, human epidermal growth factor receptor type 2 equivocation, and a high Ki-labelling index of 50% . Diagnostic physicians should note that retained rim enhancement may predict the biological aggressiveness of mucinous breast cancers.  \nCategories: Other, Radiology, Oncology  \nKeywords: breast cancer, high ki-67 labelling index, mucinous breast cancer, retained rim enhancement, thick fibrous septa  \nIntroduction  \nMucinous breast cancer is one of breast cancer 's special subtypes and is roughly grouped into a mixed subtype, i.e., a phenotype combined with mucinous carcinoma and invasive ductal carcinoma, and a pure subtype. The biology of the former is determined by the co-existing invasive ductal carcinoma components, whereas that of the latter is generally favorable [1] . In short, pure mucinous breast cancer is usually hormone-sensitive, has no lymph node metastasis, and has a low Ki-67 labeling index.  \nMucinous breast cancers present characteristic image findings due to the abundant presence of mucus around the cancer cells. Typical images of them are well-demarcated masses with distinct borders, internal high echoes on ultrasound [2], and a plateau or persistent pattern on subtraction magnetic resonance images (MRI) [3] . Internal high echoes are generated by the ultrasound wave backscattering due to the markedly different acoustic impedance between the cancer cells and the surrounding mucus [4,5] . A plateau or a persistent pattern on MRI is caused by the abundant presence of mucus around sparse cancer cells [3] .  \nWe herein report a very rare aggressive pure mucinous breast cancer with retained rim enhancement on MRI.  \nCase Presentation  \nA 44-year-old woman noticed that a very small nodule in the inner upper quadrant of her left breast had rapidly grown in size over only two months. Mammography only showed focal asymmetric density in the left breast (Figure 1) .  \nHow to cite this article  \nTakahashi H , Oura S (February 25 , 2025) Retained Rim Enhancem","cbCaieBPojaOsylp","https://ap.wps.com/l/cbCaieBPojaOsylp","pdf",2938295,"English","# Abstract\n# Introduction\n# Case Presentation\n# How to cite\n# Figures","[{\"question\":\"What key MRI feature was central to this case report?\",\"answer\":\"Subtraction MRI demonstrated early and retained rim enhancement patterns of the tumor.\"},{\"question\":\"How was the diagnosis of mucinous breast cancer established?\",\"answer\":\"Core needle biopsy showed atypical papillary cells with abundant mucus, leading to the diagnosis.\"},{\"question\":\"What pathological and immunostaining findings supported aggressive biology?\",\"answer\":\"Post-operative pathology showed ring-distributed tumor cells with extremely sparse cells in the mass center and thick fibrous septa, with high Ki-67 (50%) and estrogen/progesterone receptor positivity and HER2 equivocation.\"}]","Retained Rim Enhancement in Mucinous Breast Cancer Suggests Aggressive Biology - A Case Report | PDF",1790197054,15]