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Heart failure was induced by coronary artery ligation, then animals received intraperitoneal resveratrol (2.5 mg/kg) during the final week. Epicardial optical mapping measured action potential duration and calcium transient duration alongside fibrosis, apoptosis, and ion-channel/cardiac calcium-handling protein and mRNA expression. Resveratrol restored cardiac function, reduced electrophysiological and arrhythmia endpoints, and attenuated fibrosis, apoptosis, and NF-κB-driven inflammation.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/resveratrol-suppresses-susceptibility-of-ventricular-arrhythmia-in-heart-failure-model/457767/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/resveratrol-suppresses-susceptibility-of-ventricular-arrhythmia-in-heart-failure-model/457767.png","ImageObject",300,407,{"name":92,"@type":93},"nayy☆","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-03","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",13,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What was the primary aim of this study?","Question",{"text":113,"@type":114},"To evaluate resveratrol’s efficacy in reducing ventricular arrhythmia susceptibility and modulating calcium handling in a heart failure model.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How was the heart failure model created and how was resveratrol administered?",{"text":118,"@type":114},"Heart failure was established five weeks after coronary artery ligation, and resveratrol was given intraperitoneally (2.5 mg/kg) during the last week.",{"name":120,"@type":111,"acceptedAnswer":121},"What key electrophysiological findings were reported for the resveratrol-treated group?",{"text":122,"@type":114},"Resveratrol reduced APD80 and CaiTD80 and decreased ventricular arrhythmia induction as well as frequency-related and phase singularity-related measures.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},457767,1790814733,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":105,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},962090893153,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","Tsai etal. BMC Cardiovascular Disorders (2026) 26:13 BMC Cardiovascular Disorders  \n[https://doi.org/10.1186/s12872-025-05398-w](https://doi.org/10.1186/s12872-025-05398-w)  \nRESEARCH Open Access  \nResveratrol suppresses susceptibility of ventricular arrhythmia in heart failure model  \nYung-Nan Tsai 1,2, Ya-Wen Hsiao 1,2, Ting-Yung Chang 1,2,3, Chen-Chung Liao4, Chin-Yu Lin 1,2,3, Yu-Cheng Hsieh5, Tze-Fan Chao 1,2,3, Guan-Yi Li5, Yu-Ting Huang 1,2, Satoshi Higa6, Shih-Ann Chen 1,2,3,5,7,8 and Shih-Lin Chang 1,2,3,9*  \nAbstract  \nBackground This study investigated the efficacy of resveratrol in reducing ventricular arrhythmia (VA) and modulating calcium handling in a heart failure (HF) model.  \nMethods HF rabbits were established five weeks after coronary artery ligation. The groups included control, HF rabbits, and HF rabbits treated with intraperitoneal injections of resveratrol 2.5 mg/kg (HF + Res group) in the last week. The electrophysiology of the left ventricle (LV) was investigated using epicardial optical mapping. The action potential duration (APD), calcium transient duration (CaiTD), level of fibrosis and apoptosis, and protein and mRNA levels of ion channel s and calcium-handling proteins were also measured.  \nResults The HF group demonstrated a reduction in LV ejection fraction, an augmentation in APD80 and CaiTD80, and an escalation in VA inducibility. The administration of resveratrol resulted in the restoration of cardiac function, a reduction in APD80 and CaiTD80, and a decrease in VA, phase singularities, and dominant frequency. In HF, the expression of ion channels such as Cav1 . 2, RyR, Nav1 . 5, Kv1 .4, Kv1 . 5, and Kir2 .1 was significantly decreased. The level of SERCA2a, a calcium pump essential for intracellular calcium regulation, was also reduced. Treatment with resveratrol effectively restored the expression of these proteins. Concurrently, HF-induced elevations in fibrosis (collagen I), apoptosis (caspase-3), and inflammation (NF-κB) were significantly attenuated by resveratrol. Proteomic profiling further revealed differential regulation of ion channel–associated proteins and enrichment of cardioprotective signaling pathways, underscoring the therapeutic potential of resveratrol in HF.  \nConclusions Resveratrol ameliorates calcium handling, reverses structural and electrical remodeling, and suppresses VA in a rabbit HF model.  \nKeywords Calcium handling, Ventricular arrhythmia, Heart failure, Ion channels, Optical mapping  \n*Correspondence: Shih-Lin Chang  \nep.slchang@msa.hinet.net  \nFull list of author information is available at the end of the article  \n© The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://creati](http://creati)[vecommons.org/l](vecommons.org/l)icenses/by-nc-nd/4.0/.  \nTsai et al. BMC Cardiovascular Disorders (2026) 26:13 Page 2 of 13  \nGraphical abstract  \nIntroduction  \nResveratrol (3,5,4′-trihydroxy-trans-stilbene), a natural phenol present in low concentrations in red wine, is valued for its cardioprotective effects [1–3]. Studies have demonstrat","cbCaikrNbCw9mZ3S","https://ap.wps.com/l/cbCaikrNbCw9mZ3S","pdf",4935075,"English","# Abstract\n# Introduction\n# Materials and methods\n## Ethical considerations","[{\"question\":\"What was the primary aim of this study?\",\"answer\":\"To evaluate resveratrol’s efficacy in reducing ventricular arrhythmia susceptibility and modulating calcium handling in a heart failure model.\"},{\"question\":\"How was the heart failure model created and how was resveratrol administered?\",\"answer\":\"Heart failure was established five weeks after coronary artery ligation, and resveratrol was given intraperitoneally (2.5 mg/kg) during the last week.\"},{\"question\":\"What key electrophysiological findings were reported for the resveratrol-treated group?\",\"answer\":\"Resveratrol reduced APD80 and CaiTD80 and decreased ventricular arrhythmia induction as well as frequency-related and phase singularity-related measures.\"}]","Resveratrol suppresses susceptibility of ventricular arrhythmia in heart failure model | PDF",1790750409,33]