[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-440161-105":59,"doc-detail-440161-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","response-to-letter-by-dr-verbeck","Response to Letter by Dr. Verbeck","","Response letter acknowledging Dr. Verbeek’s concerns about statistical methods in a systematic review and meta-analysis on anti-obesity medications. The authors report an internal audit of datasets, code, manuscript, and supplementary files, identifying limited data extraction errors such as confusion between mean ± SEM and SD. They applied a conversion protocol and corrected entries, then reanalyzed confidence intervals and weights, maintaining support for comparative efficacy rankings and safety profiles. Supplementary Table S1 provides included trial details.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/response-to-letter-by-dr-verbeck/440161/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/response-to-letter-by-dr-verbeck/440161.png","ImageObject",300,407,{"name":92,"@type":93},"Fans","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-02","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":19},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What concerns did Dr. Verbeek raise in the letter?","Question",{"text":112,"@type":113},"Dr. Verbeek questioned the statistical methods and highlighted issues with confidence intervals arising from data extraction.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How did the authors address the identified data extraction errors?",{"text":117,"@type":113},"They conducted an internal audit, applied a standard conversion protocol from SEM to SD, corrected affected entries, and reran confidence interval and weight calculations.",{"name":119,"@type":110,"acceptedAnswer":120},"What resources are provided to support the meta-analysis transparency?",{"text":121,"@type":113},"The authors reference supplementary materials, including Table S1 in the Supplementary Appendix, which lists complete information for all included randomized controlled trials.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},440161,1792227247,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":19,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":19,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":52,"preview_page_count":4},5909892330395,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","Correspondence   \nResponse to Letter by Dr. Verbeck  \nLeiling Liu,a,f Zhiqi Li,b,f Wenrui Ye,c Pu Peng,d Yurong Wang,a Luqing Wan,a Jiangnan Li,a Mei Zhang,a Yihua Wang,d Runqi Liu,e Danyan Xu,a,∗ and Jingjing Zhangb,∗∗  \naDepartment of Cardiovascular Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China bNational Clinical Research Center for Metabolic Diseases, Metabolic Syndrome Research Center, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China  \ncDepartment of Neurosurgery, Xiangya Hospital, Changsha, Hunan, China  \ndDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China  \neInstitute for Global Health, Faculty of Population Health Sciences, University College London, London, The United Kingdom  \nWe sincerely appreciate Dr. Verbeek for your interest in our article, “Safety and effects of anti-obesity medications on weight loss, cardiometabolic, and psychological outcomes in people living with overweight or obesity: a systematic review and meta-analysis” ([https://doi.org/](https://doi.org/)[ ](https://doi.org/)[10.1016/j.eclinm.2024.103020](10.1016/j.eclinm.2024.103020)), for your meticulous scrutiny, and for raising questions about the statistical methods.  \nWe acknowledge the concerns with utmost seriousness. Following receipt of your correspondence, our team promptly undertook a comprehensive and meticulous internal audit of the datasets, code, manuscript, and supplementary files.  \nWe acknowledge the identification of a limited number of data extraction errors (e.g., occasional misinterpretation of mean ± SEM as SD) . To address these, we a̅p̅̅plied a standard conversion protocol (SD = SEM × √ n), followed by rigorous correction of all affected entries and systematic reanalysis of confidence intervals and weights at both the study and pooled levels. The robustness of our conclusions—particularly the comparative efficacy rankings and safety profiles—remained fully supported after this corrective process, with all thresholds of statistical significance and clinical interpretations preserved.  \nBelow, we address each concern in detail.  \nComment 1  \nThe authors made serious errors in the data extraction and did not provide a list of included studies with correct study references. In their first comparison: Naltrexone vs Placebo, the mean differences between Naltrexone and Placebo are correct but all the confidence intervals are incorrect. The authors mistook standard errors for standard deviations leading to  \nincorrect confidence intervals in turn leading to an incorrect pooled result. The data extraction from these studies is complicated because the treatment effect is measured as a change from baseline. This means that assumptions and calculations are needed to get the right input for the meta-analysis. See Fig. 1 for the authors’ results and note the exceptionally wide (incorrect) confidence interval for the first study.  \nResponse 1  \nWe sincerely acknowledge Dr. Verbeek for the rigorous review and insightful comments, which have been instrumental in enhancing the scholarly rigor of our manuscript.  \nIn the supplementary materials (see Table S1 in Supplementary Appendix 7), we have provided complete information for all included randomized controlled trials (drug category, first author, publication year, title, etc.) . Author names adhere to EndNote’s standard citation format, with each entry uniquely indexed to the study year and the specific anti-obesity medication under evaluation. Using this information, readers can accurately retrieve full bibliographic details and access the corresponding publications directly via Table S1 .  \nThis meta-analysis encompasses 154 randomized controlled trials involving 112,515 participants, constituting an extensive and metho","cbCaipk60w6YpE3j","https://ap.wps.com/l/cbCaipk60w6YpE3j","pdf",168685,"English","# Correspondence\n## Response to concerns about data extraction and confidence intervals\n## Supplementary materials and included trial information","[{\"question\":\"What concerns did Dr. Verbeek raise in the letter?\",\"answer\":\"Dr. Verbeek questioned the statistical methods and highlighted issues with confidence intervals arising from data extraction.\"},{\"question\":\"How did the authors address the identified data extraction errors?\",\"answer\":\"They conducted an internal audit, applied a standard conversion protocol from SEM to SD, corrected affected entries, and reran confidence interval and weight calculations.\"},{\"question\":\"What resources are provided to support the meta-analysis transparency?\",\"answer\":\"The authors reference supplementary materials, including Table S1 in the Supplementary Appendix, which lists complete information for all included randomized controlled trials.\"}]","Response to Letter by Dr. Verbeck | PDF",1790691339]