[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-156193-105":59,"doc-detail-156193-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","response-surface-methodology-assisted-surfactant-optimization-on-the-novel-resveratrol-self-assembly-nanoemulsions","Response Surface Methodology Assisted Surfactant Optimization on the Novel Resveratrol Self-assembly Nanoemulsions","","Resveratrol is leveraged for improving impaired diabetic wound healing through topical delivery, supported by its antioxidant and anti-inflammatory activity. Self-assembly nanoemulsions were formulated to ensure topical quality, using a surfactant system of Kolliphor® RH 40 and Transcutol® optimized for viscosity, pH, and percentage transmittance. A central composite design integrated with response surface methodology produced high desirability across the measured responses. Optimal composition was achieved at 5.70 g Kolliphor® RH 40 and 2.30 g Transcutol®, yielding a composite desirability value of 0.6077 and targeted physicochemical performance.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/response-surface-methodology-assisted-surfactant-optimization-on-the-novel-resveratrol-self-assembly-nanoemulsions/156193/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/response-surface-methodology-assisted-surfactant-optimization-on-the-novel-resveratrol-self-assembly-nanoemulsions/156193.png","ImageObject",300,407,{"name":92,"@type":93},"Sage","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-01","2026-08-28",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What optimization factors were studied for the resveratrol nanoemulsion surfactant system?","Question",{"text":113,"@type":114},"Viscosity, pH, and percentage transmittance were optimized for the Kolliphor® RH 40 and Transcutol® surfactant system.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Which experimental design approach was used in the study?",{"text":118,"@type":114},"A central composite design integrated with response surface methodology was applied to build a predictive model and find the optimum formulation.",{"name":120,"@type":111,"acceptedAnswer":121},"What composition was identified as the optimal surfactant condition?",{"text":122,"@type":114},"The optimal condition used 5.70 g Kolliphor® RH 40 and 2.30 g Transcutol®, producing the reported composite desirability value of 0.6077.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},156193,1787954820,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":34,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":130,"read_time":144,"preview_page_count":4},687197207057,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","ISSN 0974-3618 (Print) [www.rjptonline.org](www.rjptonline.org)  \n0974-360X (Online)  \nRESEARCH ARTICLE  \nResponse Surface Methodology Assisted Surfactant Optimization on the Novel Resveratrol Self-assembly Nanoemulsions  \nChristofori M.R.R. Nastiti1, Rini Dwiastuti1, Florentinus D.O. Riswanto2*  \n1Division of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Sanata Dharma, Yogyakarta 55282 Indonesia.  \n2Division of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Sanata Dharma, Yogyakarta 55282 Indonesia.  \n*Corresponding Author E-mail: [dikaocta@usd.ac.id](dikaocta@usd.ac.id)  \nABSTRACT:  \nResveratrol, a strong antioxidant and anti-inflammatory phytoalexin is potential to relieve impaired diabetic wound healing. Self-assembly nanoemulsions were developed to formulate good quality of resveratrol topical preparation. The surfactant system consisted of Kolliphor® RH 40 and Transcutol® were further optimized in terms of viscosity, pH and the percentage of transmittance. A central composite design combined with the response surface methodology successfully resulted in surface responses with the desirability value for viscosity, pH, and transmittance percentage were 0.99742, 0.60598, and 0.37137, respectively. These results contributed to the composite desirability of 0.6077. The optimal condition was obtained at a composition 5.70 g and 2.30 g of Kolliphor® RH 40 and Transcutol®, correspondingly.  \nKEYWORDS: Central composite design, optimization, nanoemulsion, resveratrol, surfactant.  \nINTRODUCTION:  \nThe impaired wound healing is one of diabetes mellitus complications which usually occurs in patients who fail to control their sugar levels 1,2 . This diabetic wound is aggravated by immunodeficiency, periferal neuropathy, inflammation and ischemia due to peripheral vascular disease3. Moreover, endothelial malfunction, decrease of macrofage number and functions, and impededangiogenesis were reported to be the potential reasons of the slow recovery process of wound healing2,4 . Strategies to combat the impaired wound healing have been intensively developed, including the use of nitric oxide for the therapy5, chemokyne regulation6, and exploration of natural products7–9.  \nResveratrol (E‐5‐(4‐hydroxystyryl) benzene‐1,3‐diol; RSV) is a natural polyphenolic compound which has been therapeutically claimed to reduce the risks of cardiovascular diseases 10–12 and diabetes 13,14 .  \nReceived on 16.11.2021 Modified on 10.02.2022  \nAccepted on 08.04.2022 © RJPT All right reserved  \nResearch J. Pharm. and Tech 2023; 16(1):411-417.  \nDOI: 10.52711/0974-360X.2023.00070  \nAs a natural product with strong antioxidant and antiinflammatory effects, RSV is also potential to alleviate diabetic wounds by activating the SIRT 1 signalling pathway-mediated angiogenesis, diminishing oxidative stress, and promoting fibroblast cell proliferationmigration2,15,16 .  \nAs a wound medication, topical application offers opportunities to give the best use of RSV. To provide good quality of medication, a profile of formulation which can incorporate and protect the RSV in the storage and deliver the RSV well onto the wound, is desirable. RSV topical nanocarriers have been widely developed, such as niosomes, transfersomes, ethosomes, and nanoemulsions 17–19. Self-assembly nanoemulsionshave been proven to be good quality RSV liquid formulations which show clarity, stability, and good skin penetration. 19.  \nMultivariate analysis combined with a response surface methodology is a reliable formula optimization tool which is frequently used to assist in the analysis as well as formulation area in finding the optimum condition of the composition of the factors studied20–24. Nastiti et al.25  \nreported that the formula optimisation of RSV nanoemulsions could be carried out by using the Box Behnken Design (BBD) followed by a response surface methodology application. On the factors and levels studied, they suggest","cbCaiay5fagGATYQ","https://ap.wps.com/l/cbCaiay5fagGATYQ","pdf",278793,"English","# Abstract\n# Introduction\n# Materials and Methods\n## Materials\n## Instrumentation and Software\n## Response Surface Methodology\n## Topical Nanoformulation","[{\"question\":\"What optimization factors were studied for the resveratrol nanoemulsion surfactant system?\",\"answer\":\"Viscosity, pH, and percentage transmittance were optimized for the Kolliphor® RH 40 and Transcutol® surfactant system.\"},{\"question\":\"Which experimental design approach was used in the study?\",\"answer\":\"A central composite design integrated with response surface methodology was applied to build a predictive model and find the optimum formulation.\"},{\"question\":\"What composition was identified as the optimal surfactant condition?\",\"answer\":\"The optimal condition used 5.70 g Kolliphor® RH 40 and 2.30 g Transcutol®, producing the reported composite desirability value of 0.6077.\"}]","Response Surface Methodology Assisted Surfactant Optimization on the Novel Resveratrol Self-assembly Nanoemulsions | PDF",18]