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Chest CT demonstrated upper-lobe predominant ground-glass opacities with impaired spirometric lung volumes. After endoscopic transnasal surgical CSF leak repair, CT findings resolved and pulmonary function 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2026, Article ID 9651572, 4 pages [https://doi.org/10.1155/crpu/9651572](https://doi.org/10.1155/crpu/9651572)  \nCase Report  \nResolution of Pulmonary Inflammation and Obstruction Following Repair of Cerebrospinal Fluid Leak: A Case Report and Review of the Literature  \nAnn O. Birmingham , 1 Serban A. Staicu , 1,2 Isaac L. Schmale , 1,3 and Li-Xing Man 1,3 1 University of Rochester School of Medicine & Dentistry, Rochester, New York, USA  \n2Division of Pulmonology and Critical Care Medicine, University of Rochester Medical Center, Rochester, New York, USA  \n3Department of Otolaryngology Head and Neck Surgery, University of Rochester Medical Center, Rochester, New York, USA Correspondence should be addressed to Ann O. Birmingham; [ann_birmingham@urmc.rochester.edu](ann_birmingham@urmc.rochester.edu)  \nReceived 14 November 2024; Revised 12 May 2025; Accepted 13 November 2025  \nAcademic Editor: Tun-Chieh Chen  \nCopyright © 2026 Ann O. Birmingham et al. Case Reports in Pulmonology published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \nObjectives: Cerebrospinal fluid (CSF) rhinorrhea involves drainage of CSF through the nasal cavity due to disruption of the skull base, and pneumonitis secondary to CSF aspiration is a lesser-known complication reported. We present the case of a patient whose pulmonary symptoms and function improved after surgical CSF leak repair.  \nMethods: This is a case report with review of the electronic medical record and literature review.  \nResults: A 35-year-old female presented with 1 year of refractory right-sided rhinorrhea and recurrent lower respiratory infections. Nasal drainage was positive for beta-2-transferrin. Sinus CT showed a possible leakage site at the right lateral lamella of the cribriform plate. Chest CT showed upper lobe predominant ground-glass opacities. Following surgical CSF leak repair, chest CT showed resolution of ground-glass opacities and pulmonary function testing showed an increase in spirometric lung volumes.  \nConclusions: Aspiration pneumonitis from CSF leaks is rarely reported. Studies report resolution of ground-glass opacities on chest CT as well as clinical improvement in symptoms such as cough following surgical leak repair. Proposed mechanisms leading to aspiration pneumonitis include nasopharyngeal bacterial transit; the mechanism of persistent leak may be related to cough-induced increase in intracranial pressure leading to increased CSF flow. In patients with lower airway inflammation and obstruction as well as unexplained aspiration pneumonitis, a high index of suspicion for CSF rhinorrhea is warranted.  \nKeywords: aspiration; cerebrospinal fluid rhinorrhea; CSF rhinorrhea; pneumonitis; runny nose  \n1. Introduction  \nCerebrospinal fluid (CSF) rhinorrhea involves drainage of CSF through the nasal cavity due to disruption of the skull base [1] . Most cases are secondary to trauma, either accidental or iatrogenic, but may also develop spontaneously [1, 2] . In addition to rhinorrhea, patients may also present with headache, symptoms of rhinosinusitis or allergic rhinitis, tinnitus, and visual or olfactory disturbances [1, 3] . A serious complication ofCSF rhinorrhea includes ascending infection leading to meningitis; thus, surgical repair is usually recom-  \nmended [4, 5] . To confirm the diagnosis, beta-2-transferrin testing of nasal discharge is performed, which is known to have high specificity and sensitivity [4] . Following a positive beta-2-transferrin test, imaging is performed to evaluate for  \nstructural abnormalities and localize the source [2, 3] .  \nAspiration pneumonitis involves inflammation of lung tissue, usually due to the entry of gastric or oropharyngeal contents into the lower respiratory tract [6, 7] . In addition, there is eviden","cbCaidgcME81h6tg","https://ap.wps.com/l/cbCaidgcME81h6tg","pdf",1013164,"English","# Objectives\n# Methods\n# Results\n# Conclusions\n# Introduction\n# Case Description","[{\"question\":\"What was the patient’s initial clinical presentation?\",\"answer\":\"The patient presented with approximately one year of clear, right-sided rhinorrhea and recurrent lower respiratory infections requiring oral antibiotics and steroid treatment.\"},{\"question\":\"How was cerebrospinal fluid rhinorrhea confirmed?\",\"answer\":\"Nasal drainage was positive for beta-2-transferrin, and imaging was used to localize a possible leakage site at the right lateral lamella of the cribriform plate.\"},{\"question\":\"What changes were observed after surgical repair?\",\"answer\":\"Following endoscopic transnasal CSF leak repair, chest CT showed resolution of ground-glass opacities and pulmonary function testing demonstrated increased spirometric lung volumes.\"}]","Resolution of Pulmonary Inflammation and Obstruction Following Repair of Cerebrospinal Fluid Leak - A Case Report and Review of the Literature | PDF",1790741342]