[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-379049-105":59,"doc-detail-379049-en":129},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":122,"head_meta":124,"extra_data":126,"updated_unix":128},105,"en","resident-esophageal-microbiota-dysbiosis-correlates-with-cancer-risk-in-barretts-esophagus-patients-study-summary-and-lifestyle-link","Resident Esophageal Microbiota Dysbiosis Correlates with Cancer Risk in Barrett's Esophagus Patients - Study Summary and Lifestyle Link","","Esophageal adenocarcinoma arises after long-standing gastroesophageal reflux and inflammation, with Barrett's esophagus serving as a key precursor and risk factor. The study investigates the resident esophageal microbiome across non-dysplastic BE, low- and high-grade dysplasia, and EAC to characterize progression parameters and build a clinical stratification score. Using 16S rRNA gene sequencing of esophageal biopsies, the work applies multivariate analysis to identify significant microbial features and develop a multiparametric test, then evaluates diagnostic performance and thresholds for distinguishing dysplastic/cancer patients, including links to diet and lifestyle.",{"@graph":69,"@context":121},[70,84,104],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/resident-esophageal-microbiota-dysbiosis-correlates-with-cancer-risk-in-barretts-esophagus-patients-study-summary-and-lifestyle-link/379049/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":98,"encodingFormat":97,"isAccessibleForFree":99,"interactionStatistic":100},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/resident-esophageal-microbiota-dysbiosis-correlates-with-cancer-risk-in-barretts-esophagus-patients-study-summary-and-lifestyle-link/379049.png","ImageObject",300,407,{"name":92,"@type":93},"WPS_1786070896","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-24",true,{"@type":101,"interactionType":102,"userInteractionCount":8},"InteractionCounter",{"@type":103},"ViewAction",{"@type":105,"mainEntity":106},"FAQPage",[107,113,117],{"name":108,"@type":109,"acceptedAnswer":110},"What does the study aim to do in Barrett's esophagus patients?","Question",{"text":111,"@type":112},"It explores esophageal microbial profiles across stages of Barrett's esophagus and EAC to identify parameters of cancer progression and to develop a multiparametric risk score for clinical use.","Answer",{"name":114,"@type":109,"acceptedAnswer":115},"How was the esophageal microbiota measured?",{"text":116,"@type":112},"The microbiota was investigated using 16S rRNA gene sequencing of esophageal biopsies, with microbial composition evaluated at multiple taxonomic levels along disease progression.",{"name":118,"@type":109,"acceptedAnswer":119},"How does the study connect microbiome signals with diet or lifestyle?",{"text":120,"@type":112},"After building and validating the microbial progression test, it investigates relationships between microbial parameters and patients' diet/lifestyle habits, consistent with lifestyle recommendations referenced in the article.","https://schema.org",{"og:url":83,"og:type":123,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":125,"canonical":83},"index,follow",{"doc_id":127,"site_id":62},379049,1790246211,{"code":4,"msg":5,"data":130},{"doc_id":127,"user_id":131,"nickname":92,"user_avatar":132,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":133,"file_id":134,"file_url":135,"file_type":136,"file_size":137,"view_count":8,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":138,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},549768072016,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","nutrients   \nArticle  \nResident Esophageal Microbiota Dysbiosis Correlates with Cancer Risk in Barrett's Esophagus Patients and Is Linked to Low Adherence to WCRF/AICR Lifestyle Recommendations  \nAlice Zaramella 1,2, *, Diletta Arcidiacono 2, Daniele Nucci 3, Federico Fabris 4, Clara Benna 1, Salvatore Pucciarelli 1, Matteo Fassan 5,6, Alberto Fantin 2, Vall¼ De Re 7, Renato Cannizzaro 8,9 and Stefano Realdon 8  \nCitation: Zaramella, A.; Arcidiacono, D.; Nucci, D.; Fabris, F.; Benna, C.; Pucciarelli, S.; Fassan, M.; Fantin, A.; De Re, V.; Cannizzaro, R.; et al. Resident Esophageal Microbiota Dysbiosis Correlates with Cancer Risk in Barrett's Esophagus Patients and Is Linked to Low Adherence to WCRF/AICR Lifestyle Recommendations. Nutrients 2023, 15, 2885. [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)nu15132885  \nAcademic Editor: Cheng-Chia Yu  \nReceived: 30 May 2023  \nRevised: 19 June 2023  \nAccepted: 20 June 2023  \nPublished: 26 June 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Department of Surgery, Oncology and Gastroenterology (DiSCOG), University of Padua, Via Giustiniani 2, 35128 Padua, Italy; [clara.benna@unipd.it](clara.benna@unipd.it) (C.B.); [puc@unipd.it](puc@unipd.it) (S.P.)  \n2 Gastroenterology Unit, Veneto Institute of Oncology IOV-IRCCS, Via Gattamelata 64, 35128 Padua, Italy; [diletta.arcidiacono@iov.veneto.it](diletta.arcidiacono@iov.veneto.it) (D.A.); [alberto.fantin@iov.veneto.it](alberto.fantin@iov.veneto.it) (A.F.)  \n3 Dietetics and Clinical Nutrition Unit, Veneto Institute of Oncology IOV-IRCCS, Via Gattamelata 64,  \n35128 Padua, Italy; [daniele.nucci@iov.veneto.it](daniele.nucci@iov.veneto.it)  \n4 Department of Biomedical Sciences, University of Padua, Viale Colombo 3, 35121 Padua, Italy; [federico.fabris.5@phd.unipd.it](federico.fabris.5@phd.unipd.it)  \n5 Department of Medicine (DIMED), University of Padua, Via Gabelli 61, 35121 Padua, Italy; [matteo.fassan@unipd.it](matteo.fassan@unipd.it)  \n6 Veneto Institute of Oncology IOV-IRCCS, Via Gattamelata 64, 35128 Padua, Italy  \n7 Immunopathology and Cancer Biomarkers, Centro di Riferimento Oncologico di Aviano (CRO), National Cancer Institute, IRCCS, 33081 Aviano, Italy; vdere@cro.it  \n8 Oncological Gastroenterology, Centro di Riferimento Oncologico di Aviano (CRO), National Cancer Institute, IRCCS, 33081 Aviano, Italy; [rcannizzaro@cro.it](rcannizzaro@cro.it) (R.C.); [stefano.realdon@cro.it](stefano.realdon@cro.it) (S.R.)  \n9 Department of Medical, Surgical and Health Sciences, University of Trieste, 34127 Trieste, Italy  \n* Correspondence: [alice.zaramella@unipd.it](alice.zaramella@unipd.it)  \nAbstract: Esophageal adenocarcinoma (EAC) is the consequence of longstanding gastroesophageal reflux, which leads to inflammation and could cause Barrett's esophagus (BE), the main risk factor for EAC development. The 5 year survival rate of EAC is poor since the diagnosis occurs at the late stage of the disease. To improve patient management, a better comprehension of the mechanism undergoing the evolution through to adenocarcinoma is needed. Within this scenario, the resident microbiome investigation was studied. This study aimed to explore the esophageal microbial profile in patients affected by non-dysplastic BE, low-and high-grade dysplastic BE, and EAC to identify parameters characterizing cancer progression and to develop a score suitable for clinical practice to stratify cancer risk. The microbiota was investigated through the 16S rRNA gene sequencing of esophageal biopsies. The microbial composition was evaluated at each different taxonomic level along the disease progression. To further investigate bacteri","cbCaikgXhaaOj46s","https://ap.wps.com/l/cbCaikgXhaaOj46s","pdf",4749998,21,"English","# Abstract\n# Introduction\n## Esophageal cancer background and risk","[{\"question\":\"What does the study aim to do in Barrett's esophagus patients?\",\"answer\":\"It explores esophageal microbial profiles across stages of Barrett's esophagus and EAC to identify parameters of cancer progression and to develop a multiparametric risk score for clinical use.\"},{\"question\":\"How was the esophageal microbiota measured?\",\"answer\":\"The microbiota was investigated using 16S rRNA gene sequencing of esophageal biopsies, with microbial composition evaluated at multiple taxonomic levels along disease progression.\"},{\"question\":\"How does the study connect microbiome signals with diet or lifestyle?\",\"answer\":\"After building and validating the microbial progression test, it investigates relationships between microbial parameters and patients' diet/lifestyle habits, consistent with lifestyle recommendations referenced in the article.\"}]","Resident Esophageal Microbiota Dysbiosis Correlates with Cancer Risk in Barrett's Esophagus Patients - Study Summary and Lifestyle Link | PDF",1790233882,53]