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R0 was more frequent in rectal lesions. Complications occurred in 15%, with perforation strongly linked to right-sided procedures.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/resection-of-early-colorectal-neoplasms-using-endoscopic-submucosal-dissection-a-retrospective-multicenter-cohort-study/337071/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/resection-of-early-colorectal-neoplasms-using-endoscopic-submucosal-dissection-a-retrospective-multicenter-cohort-study/337071.png","ImageObject",300,407,{"name":42,"@type":43},"Evangeline","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-28","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",13,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What was the goal of this study on ESD for early colorectal neoplasms?","Question",{"text":63,"@type":64},"To analyze factors influencing the ESD procedure in early colorectal cancer in order to improve its effectiveness.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What were the main outcomes after ESD in the 214-patient cohort?",{"text":68,"@type":64},"En bloc resection was achieved in 92.1%, R0 resection in 69.6%, and curative resection in 40.9%.",{"name":70,"@type":61,"acceptedAnswer":71},"How did complication rates differ by tumor location?",{"text":72,"@type":64},"Right colon procedures showed a higher risk of complications and perforations than rectum and left colon procedures.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},337071,1790373952,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":140,"language":141,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":12,"update_tm":145,"read_time":108},13056703019662,"https://ap-avatar.wpscdn.com/avatar/be000253a8e92610077?_k=1778726343310543188","Article  \nResection of Early Colorectal Neoplasms Using Endoscopic Submucosal Dissection: A Retrospective Multicenter Cohort Study  \nKatarzyna Winter 1, *, Przemysław Kasprzyk 1, Zuzanna Nowicka 2, Suzuki Noriko 3, Alberto Herreros-de-Tejada 4 and Michał Spychalski 1,5  \nCitation: Winter, K.; Kasprzyk, P.; Nowicka, Z.; Noriko, S.; Herrerosde-Tejada, A.; Spychalski, M. Resection of Early Colorectal Neoplasms Using Endoscopic Submucosal Dissection: A Retrospective Multicenter Cohort Study. J. Clin. Med. 2024, 13, 6989 . [https://doi.org/10.3390/jcm13226989](https://doi.org/10.3390/jcm13226989)  \nAcademic Editors: Reinhold Függer and Rainer Schöfl  \nReceived: 24 September 2024  \nRevised: 23 October 2024  \nAccepted: 29 October 2024  \nPublished: 20 November 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Center of Bowel Treatment, 95-060 Brzeziny, Poland; [kasprzykprzemek@gmail.com](kasprzykprzemek@gmail.com) (P.K.); [mspych80@gmail.com](mspych80@gmail.com) (M.S.)  \n2 Department of Biostatistics and Translational Medicine, Medical University of Lodz, 92-215 Lodz, Poland; [zuzannow@gmail.com](zuzannow@gmail.com)  \n3 St Mark’s Hospital and Academic Institute, London North West Healthcare NHS Trust, Harrow HA1 3UJ, UK; [norikosuzuki@nhs.net](norikosuzuki@nhs.net)  \n4 Department of Gastroenterology, Puerta de Hierro University Hospital, IDIPHISA—Instituto de Investigación Sanitaria Puerta de Hierro-Segovia de Arana, 28222 Majadahonda, Spain  \n5 Department of General and Oncological Surgery, Medical University of Lodz, 92-213 Lodz, Poland  \n* Correspondence: [drkatarzynawinter@gmail.com](drkatarzynawinter@gmail.com); Tel.: +48-500275615  \nAbstract: Background: Endoscopic submucosal dissection (ESD) is a reliable method that can replace surgery in the treatment of early colorectal cancer under certain conditions. Aim: The aim of the study was to analyze factors influencing the ESD procedure in early colorectal cancer, with the intention of improving its effectiveness. Patients and Methods: We conducted a multicenter, retrospective cohort study on 214 patients who underwent ESD procedures for early colorectal cancer from January 2016 to October 2023 . Results: En bloc resection was achieved in 197 (92.1%) of ESD procedures, R0 resection in 149 (69.6%), and curative resection in 54 (40.9%) . The submucosal invasion was classified as level 1 (SM1) in 96 cases (45.3%), level 2 (SM2) in 61 cases (28.8%), and level 3 (SM3) in 36 cases (17%) . R0 resection was achieved more often in the rectum—92 (81.4%), compared to the right—24 (64.9%) and left colon—33 (61.1%), p = 0.009 . In rectal tumors, R0 resection was achieved in 51 (98.1%) SM1 invasion, 27 (73%) SM2 invasion, and 13 (65%) SM3 invasion (p \u003C 0.001) . Lateral and vertical resection margins were positive in 12 (7.7%) and 52 (25.2%) cases, respectively. Vertical resection margins were statistically more often positive in lesions located in the right colon—11 cases (28.9%) and left colon—21 cases (38.9%), than in rectum—20 cases (17.5%); p = 0.010 . Complications were found in 32 (15%) cases of ESD procedure—perforation in 12 cases (5.6%) and delayed bleeding in four cases (1.9%) . Procedures performed in the right colon were associated with a significantly higher risk of any complications (30%) and perforations (15%) than those performed in the rectum (10.3% and 2.6%) or the left colon (13.8% and 5.2%; p = 0.016; p = 0.015), respectively. Conclusions: ESD for early colon cancer is a viable strategy due to its effectiveness and low complication rate. The ESD technique performed in the rectum yields the best results; however, in the right colon, it still requires careful atten","cbCairThKPHXf0Q2","https://ap.wps.com/l/cbCairThKPHXf0Q2","pdf",1275472,16,"English","# Abstract\n## Background\n## Aim\n## Patients and Methods\n## Results\n## Conclusions\n# Introduction","[{\"question\":\"What was the goal of this study on ESD for early colorectal neoplasms?\",\"answer\":\"To analyze factors influencing the ESD procedure in early colorectal cancer in order to improve its effectiveness.\"},{\"question\":\"What were the main outcomes after ESD in the 214-patient cohort?\",\"answer\":\"En bloc resection was achieved in 92.1%, R0 resection in 69.6%, and curative resection in 40.9%.\"},{\"question\":\"How did complication rates differ by tumor location?\",\"answer\":\"Right colon procedures showed a higher risk of complications and perforations than rectum and left colon procedures.\"}]","Resection of Early Colorectal Neoplasms Using Endoscopic Submucosal Dissection - A Retrospective Multicenter Cohort Study | PDF",1790017624]