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[homepage:](homepage: www.cell.com/heliyon)[ www.cell.com/heliyon](homepage: www.cell.com/heliyon)  \n| Review article\u003Cbr>Research trends and hotspots of polyphyllin in high-incidence cancers: A bibliometric analysis\u003Cbr>Xin Jiang a, 1, Zhen Liu a, 1, Runlan Wan b, Renming Caia, Jiaxin Yanga, Linfeng Lia, Huiling Hua, Lilan Oua, c, Chun Zhang a, c, **, Qiuyu Liu a, *\u003Cbr>a School of Pharmacy, Southwest Medical University, Luzhou, 646000, China\u003Cbr>b Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, China\u003Cbr>c Key Laboratory ofLuzhou City for Aging Medicine, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, China |  |\n| --- | --- |\n| A R T I C L E I N F O\u003Cbr>Keywords: Polyphyllin Bibliometrics\u003Cbr>Breast cancer\u003Cbr>Lung cancer\u003Cbr>Liver cancer | A B S T R A C T\u003Cbr>Background: Polyphyllin, a natural compound derived primarily from the Paris genus, manifestsits anticancer properties. Extensive research on its therapeutic potential in cancers has been reported. However, there is no systematical analysis of the general aspects of research on polyphyllin by bibliometric analysis. The aim of this study is to visualize emerging trends and hotspots and predict potential research directions in this field.\u003Cbr>Methods: In this study, we collected relevant research articles from the Web of Science Core Collection Bibliometrics. Using R-bibliometrix, we analyzed the research status, hotspots, frontiers, and development trends of polyphyllin in high-incidence cancers. To conduct a comprehensive visual analysis, CiteSpace and VOSviewer were used for visual analysis of authors, countries, institutions, keywords, and co-cited references within the published articles.\u003Cbr>Results: A total of 257 articles focusing on the research of polyphyllin in high-incidence cancers were retrieved from the WOSCC database, covering the period from 2005 to 2023. The analysis revealed a consistent increasing trend in annual publications during this timeframe. Notably, China emerged as the most productive country, with Tianjin University leading the institutions. The Journal of Ethnopharmacology stood out as the most prominent journal in this field, while Gao WY emerged as the most prolific author. Polyphyllin VI, polyphyllin II, and polyphyllin VII have emerged as the latest research hotspots. Additionally, the investigation of autophagy and its associated mechanisms has gained significant attention as a novel research direction. Conclusion: This study presents a novel visualization of the research on polyphyllin saponins in the field of highly prevalent cancers using bibliometric analysis. The investigation of polyphyllin D has emerged as a primary focus in this field, with lung cancer, breast cancer, and liver cancer being the key areas of current research. Lastly, polyphyllin saponins show potential application in the field of cancer. |\n\n* Corresponding author.  \n** Corresponding author. School of Pharmacy, Southwest Medical University, Luzhou, 646000, China.  \nE-mail addresses: [zc83good@126.com](zc83good@126.com) (C. Zhang), [q.liu@swmu.edu.cn](q.liu@swmu.edu.cn) (Q. Liu).  \n1 These authors have contributed equally to this work and share first authorship.  \n[https://doi.org/10.1016/j.heliyon.2024.e27804](https://doi.org/10.1016/j.heliyon.2024.e27804)  \nReceived 2 January 2024; Received in revised form 26 February 2024; Accepted 6 March 2024 Available online 8 March 2024  \n2405-8440/© 2024 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license ([http://creativecommons.org/licenses/by-nc-nd/4.0/](http://creativecommons.org/licenses/by-nc-nd/4.0/)).  \n1. Introduction  \nCancer has the high mortality and it is one of the primary causes of death in countries around the world. The incidence of cancer is increasing with the growing global agi","cbCaip2kF9JGlibA","https://ap.wps.com/l/cbCaip2kF9JGlibA","pdf",6898797,14,"English","# Introduction\n## Polyphyllin background and anticancer mechanisms\n## Motivation for bibliometric analysis","[{\"question\":\"What is the main objective of this study?\",\"answer\":\"To visualize emerging research trends and hotspots of polyphyllin in high-incidence cancers and predict potential future research directions.\"},{\"question\":\"Which databases and tools are used for the bibliometric analysis?\",\"answer\":\"Relevant articles are collected from the Web of Science Core Collection, and analyses are performed using R-bibliometrix, with CiteSpace and VOSviewer used for visualization of entities and co-cited references.\"},{\"question\":\"What major research hotspots and future directions are highlighted?\",\"answer\":\"Polyphyllin VI, polyphyllin II, and polyphyllin VII are identified as recent hotspots, and research on autophagy and its mechanisms is emphasized as a notable emerging direction.\"}]","Research trends and hotspots of polyphyllin in high-incidence cancers - A bibliometric analysis | PDF",1790001593,35]