[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-339241-105":59,"doc-detail-339241-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","research-progress-on-venous-thrombosis-development-in-patients-with-malignant-tumors","Research progress on venous thrombosis development in patients with malignant tumors","","Cancer-associated thrombosis (CAT) represents a major cause of mortality among patients with cancer, arising from the coexistence of venous thromboembolism within this population. Incidence of VTE increases across tumor types under the influence of patient management, tumor-specific risks, and treatment-related factors. Genetic mutations have also been implicated in higher CAT occurrence in particular cancer subtypes. This review synthesizes key historical and ongoing studies to clarify risks, mechanisms, reliable markers, and risk assessment methods that support effective clinical intervention.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/research-progress-on-venous-thrombosis-development-in-patients-with-malignant-tumors/339241/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/research-progress-on-venous-thrombosis-development-in-patients-with-malignant-tumors/339241.png","ImageObject",300,407,{"name":92,"@type":93},"Ava Thompson","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-27","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is cancer-associated thrombosis (CAT) and why is it important?","Question",{"text":112,"@type":113},"CAT refers to the coexistence of venous thromboembolism (VTE) in patients with cancer. It is a prominent cause of mortality in this population.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which factors contribute to the development and increasing incidence of VTE in cancer patients?",{"text":117,"@type":113},"VTE incidence increases due to patient management, tumor-specific risks, treatment-related aspects, and potential gene mutations linked to specific cancer subtypes.",{"name":119,"@type":110,"acceptedAnswer":120},"How do patient-, tumor-, and treatment-related factors affect CAT risk?",{"text":121,"@type":113},"Patient factors include age, gender, smoking, alcohol consumption, obesity, and nutritional requirements; tumor risks relate to type and stage; treatment-related therapies such as chemotherapy and other drug classes can markedly increase thrombotic events.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},339241,1790315716,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},1649267921044,"https://us-avatar.wpscdn.com/avatar/1800007509477c92dfb?_k=1786009248482753345","| W | J | C | C | World Journal of\u003Cbr>Clinical Cases |\n| --- | --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Clin Cases 2024 April 16; 12(11): 1900-1908  \nDOI: 10.12998/wjcc.v12.i11.1900 ISSN 2307-8960 (online)  \nMINIREVIEWS  \nResearch progress on venous thrombosis development in patients with malignant tumors  \nTeng-Fei Wang, Qian Chen, Jie Deng, Shi-Liang Li, Yuan Xu, Si-Xing Ma  \nSpecialty type: Medicine, research and experimental  \nProvenance and peer review:  \nUnsolicited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s scientific quality classification  \nGrade A (Excellent): 0  \nGrade B (Very good): 0  \nGrade C (Good): C  \nGrade D (Fair): 0  \nGrade E (Poor): 0  \nP-Reviewer: Di Donato V, Italy  \nReceived: January 15, 2024  \nPeer-review started: January 15, 2024  \nFirst decision: February 23, 2024  \nRevised: March 4, 2024  \nAccepted: March 20, 2024  \nArticle in press: March 20, 2024  \nPublished online: April 16, 2024  \nTeng-Fei Wang, Jie Deng, Shi-Liang Li, Si-Xing Ma, Department of Vascular Surgery, The Affiliated Hospital of Guizhou Medical University, Guiyang 550000, Guizhou Province, China  \nQian Chen, Yuan Xu, Department of Organ Transplantation, The Affiliated Hospital of Guizhou Medical University, Guiyang 550000, Guizhou Province, China  \nCorresponding author: Si-Xing Ma, PhD, Chief Physician, Department of Vascular Surgery, The Affiliated Hospital of Guizhou Medical University, No. 28 Guimedical Street, Yunyan District, Guiyang 550000, Guizhou Province, [China.](China. masixing168@163.com)[ masixing168@163.com](China. masixing168@163.com)  \nAbstract  \nThe coexistence of venous thromboembolism (VTE) within patients with cancer, known as cancer-associated thrombosis (CAT), stands as a prominent cause of mortality in this population. Over recent years, the incidence of VTE has demonstrated a steady increase across diverse tumor types, influenced by several factors such as patient management, tumor-specific risks, and treatment-related aspects. Furthermore, mutations in specific genes have been identified as potential contributors to increased CAT occurrence in particular cancer subtypes. We conducted an extensive review encompassing pivotal historical and ongoing studies on CAT. This review elucidates the risks, mechanisms, reliable markers, and risk assessment methodologies that can significantly guide effective interventions in clinical practice.  \nKey Words: Malignant tumor; Venous thromboembolism; Cancer-associated thrombosis; Research progress  \n©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.  \nCore Tip: Treatment-related risks involve therapies such as chemotherapy, endocrine therapy, angiogenesis inhibitors, immunotherapy, protein kinase inhibitors, blood transfusions, and cell line stimulants, all contributing to venous thromboembolism. This review summarizes the pathogenesis of cancer-associated thrombosis and treatment approaches for this condition. This review elucidates the risks, mechanisms, reliable markers, and risk assessment methodologies that can significantly guide effective interventions in clinical practice.  \n WJCC  [https://www.wjgnet.com](https://www.wjgnet.com) 1900 April 16, 2024  Volume 12  Issue 11   \nWang TF et al. CAT of malignant tumors  \nCitation: Wang TF, Chen Q, Deng J, Li SL, Xu Y, Ma SX. Research progress on venous thrombosis development in patients with malignant tumors. World J Clin Cases 2024; 12(11): 1900-1908  \nURL: [https://www.wjgnet.com/2307-8960/full/v12/i11/1900.htm](https://www.wjgnet.com/2307-8960/full/v12/i11/1900.htm)  \nDOI: [https://dx.doi.org/10.12998/wjcc.v12.i11.1900](https://dx.doi.org/10.12998/wjcc.v12.i11.1900)  \nWith demographic shifts and an aging population, the global incidence of tumors has steadily risen, establishing malignant tumors as a leading cause of disease mortality in the 21st century[1-3] . Cance","cbCaisgHoF2VT6T3","https://ap.wps.com/l/cbCaisgHoF2VT6T3","pdf",1728589,"English","# Abstract\n# Core Tip\n# Background and Risk Overview\n# Risk Factors (Patient- and Tumor-related)\n# Treatment-related Risks\n# Citation and Publication Information","[{\"question\":\"What is cancer-associated thrombosis (CAT) and why is it important?\",\"answer\":\"CAT refers to the coexistence of venous thromboembolism (VTE) in patients with cancer. It is a prominent cause of mortality in this population.\"},{\"question\":\"Which factors contribute to the development and increasing incidence of VTE in cancer patients?\",\"answer\":\"VTE incidence increases due to patient management, tumor-specific risks, treatment-related aspects, and potential gene mutations linked to specific cancer subtypes.\"},{\"question\":\"How do patient-, tumor-, and treatment-related factors affect CAT risk?\",\"answer\":\"Patient factors include age, gender, smoking, alcohol consumption, obesity, and nutritional requirements; tumor risks relate to type and stage; treatment-related therapies such as chemotherapy and other drug classes can markedly increase thrombotic events.\"}]","Research progress on venous thrombosis development in patients with malignant tumors | PDF",1790028919,25]