[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-332488-105":59,"doc-detail-332488-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","research-progress-on-the-role-of-adipocyte-exosomes-in-cancer-progression","Research progress on the role of adipocyte exosomes in cancer progression","","Exosomes are minute vesicles released by diverse cells, acting as essential mediators of intercellular communication and strongly linked to malignancies. Their cargo reshapes local and distant tumor-associated microenvironments, driving multiple recipient-cell biological responses. Exosome-mediated cell-to-cell signaling governs processes such as stromal reprogramming, immune reactions, extracellular matrix remodeling, and regulation of cancer growth, activation, expansion, and metastasis. Exosomes may also promote treatment resistance, supporting their development as therapeutic targets and diagnostic indicators, especially in tumorigenesis and therapeutic response.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/research-progress-on-the-role-of-adipocyte-exosomes-in-cancer-progression/332488/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/research-progress-on-the-role-of-adipocyte-exosomes-in-cancer-progression/332488.png","ImageObject",300,407,{"name":92,"@type":93},"Levi","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the central focus of this review?","Question",{"text":112,"@type":113},"The review focuses on research progress regarding the roles of adipocyte-derived exosomes in cancer progression, emphasizing how they function and interact with cancer cells and the tumor microenvironment.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How do adipocyte exosomes influence cancer progression?",{"text":117,"@type":113},"Adipocyte exosomes deliver bioactive cargo that mediates cell-to-cell communication, affecting stromal reprogramming, immune responses, extracellular matrix formation, and the activation, expansion, and metastasis of cancer cells.",{"name":119,"@type":110,"acceptedAnswer":120},"Why are exosomes considered promising for diagnosis and therapy?",{"text":121,"@type":113},"Exosomes have been investigated as therapeutic targets and diagnostic indicators because they regulate multiple processes in tumor development and may contribute to cancer treatment resistance through their cargo and signaling effects.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},332488,1790808598,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":41,"preview_page_count":4},7971461740909,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","ONCOLOGY RESEARCH 2024 32(10): 1649-1660 REVIEW  \nResearch progress on the role of adipocyte exosomes in cancer progression  \nYUN WANG 1; XIAOJIANG LI2; DALONG LIU2; ZHIFENG WANG3; JICHEN XIA4; LIJUN WANG5; XUDONG ZHANG6,*  \n1 Department of Breast and Thyroid Surgery, Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun, 130021, China  \n2 Department of Orthopaedics, Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun, 130021, China  \n3 Department of Internal Medicine, Changchun Chaoyang District Hospital of Traditional Chinese Medicine, Changchun, 130061, China  \n4 Department of Orthopedics and Traumatology, Jilin Integrated Traditional Chinese and Western Medicine Hospital of Jilin Province, Jilin, 132012, China  \n5 Department of Oncology, Liaoyuan Second People’s Hospital, Liaoyuan, 136299, China  \n6 Department of Brain Surgery, Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun, 130021, China  \nKey words: Exosomes, Extracellular vesicles, Adipose tissue, Tumor microenvironment, Obesity  \nAbstract: Exosomes, minute vesicles ubiquitously released by diverse cell types, serve as critical mediators in intercellular communication. Their pathophysiological relevance, especially in malignancies, has garnered significant attention. A meticulous exploration of the exosomal impact on cancer development has unveiled avenues for innovative and clinically valuable techniques. The cargo conveyed by exosomes exerts transformative effects on both local and distant microenvironments, thereby influencing a broad spectrum of biological responses in recipient cells. These membranebound extracellular vesicles (EVs) play a pivotal role in delivering bioactive molecules among cells and organs.  \nCellular and biological processes in recipient cells, ranging from stromal cell reprogramming to immunological responses, extracellular matrix formation, and modulation of cancer cell activation, expansion, and metastasis, are subject to exosome-mediated cell-to-cell communication. Moreover, exosomes have been implicated in endowing cancer cells with resistance to treatment. Extensive research has explored the potential of exosomes as therapeutic targets and diagnostic indicators. This comprehensive review seeks to provide an in-depth understanding of the pivotal components and roles of exosomes in tumorigenesis, growth, progression, and therapeutic responses. The insights into the multifaceted involvement of exosomes in malignant cancers are essential for the scientific community, fostering the development of novel therapeutic and diagnostic strategies in the relentless pursuit of cancer.  \nIntroduction  \nExosomes, minute lipid bilayer vesicles secreted by a majority of eukaryotic cells, have emerged as a compelling avenue for cellular waste elimination. Their role in transporting proteins, lipids, and nucleic acids from source to recipient cells underscores their pivotal function in cellular communication [1,2] . Beyond their established functions in normal physiology, heightened interest in their involvement in metabolic diseases and cancers has prompted a thorough exploration of their multifaceted properties.  \nAdipose tissues, among extracellular vesicles (EVs), standout as primary producers, serving as the fundamental conduit  \n*Address correspondance to: Xudong Zhang, [zhangxudongjj@sina.com](zhangxudongjj@sina.com)  \nReceived: 03 July 2023; Accepted: 07 April 2024;  \nPublished: 18 September 2024  \nfor intercellular communication. Notably, exosomes originating from adipose tissue (AT-exosomes) have been implicated in a spectrum of physiological and pathological processes, including metabolic disorders and cancers [3,4] . The intricate involvement of AT-exosomes in cancer development, growth, and metastasis positions them as crucial components deserving in-depth scrutiny. Despite comprehensive reviews delving into the broader role of exosomes and extra","cbCaio0QhlwyHG4v","https://ap.wps.com/l/cbCaio0QhlwyHG4v","pdf",3707885,12,"English","# Introduction\n# Exosomes: overview\n## Cellular and biological roles in cancer progression\n## Exosome-mediated signaling and tumor microenvironment interactions\n# Research focus and future directions","[{\"question\":\"What is the central focus of this review?\",\"answer\":\"The review focuses on research progress regarding the roles of adipocyte-derived exosomes in cancer progression, emphasizing how they function and interact with cancer cells and the tumor microenvironment.\"},{\"question\":\"How do adipocyte exosomes influence cancer progression?\",\"answer\":\"Adipocyte exosomes deliver bioactive cargo that mediates cell-to-cell communication, affecting stromal reprogramming, immune responses, extracellular matrix formation, and the activation, expansion, and metastasis of cancer cells.\"},{\"question\":\"Why are exosomes considered promising for diagnosis and therapy?\",\"answer\":\"Exosomes have been investigated as therapeutic targets and diagnostic indicators because they regulate multiple processes in tumor development and may contribute to cancer treatment resistance through their cargo and signaling effects.\"}]","Research progress on the role of adipocyte exosomes in cancer progression | PDF",1789998441]