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It summarizes existing findings on microbiota within bladder tumor tissues, covering roles in initiation, progression, metastasis, prognosis, and prospects for early detection, while contextualizing bladder cancer subtypes and clinical challenges.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/research-progress-on-the-microbiota-in-bladder-cancer-tumors/330460/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/research-progress-on-the-microbiota-in-bladder-cancer-tumors/330460.png","ImageObject",300,407,{"name":42,"@type":43},"Ava Thompson","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-06","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",6,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"Why is the microbiota considered important for bladder cancer research?","Question",{"text":63,"@type":64},"The microbiota is a crucial part of the human microenvironment and can influence physiological and pathological functions. Increasing evidence links microbial communities with human cancers, motivating study of their roles in bladder cancer.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How is bladder cancer (BCa) categorized in this review?",{"text":68,"@type":64},"Bladder cancer is divided into muscle-infiltrating bladder cancer (MIBC) and nonmuscle-infiltrating bladder cancer (NMIBC) based on invasion into the bladder wall muscular layer.",{"name":70,"@type":61,"acceptedAnswer":71},"What topics does the review cover regarding microbiota in bladder cancer tumors?",{"text":72,"@type":64},"The review summarizes research on how different microbes may contribute to onset, progression, metastasis, prognosis, and the potential for early detection of BCa.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},330460,1790363020,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,105,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},"Technology",50,"technology",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":107,"show_sort_weight":108,"slug":109},7,"Healthcare",40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":112,"slug":113},8,30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":111,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145,"preview_page_count":4},1649267921044,"https://us-avatar.wpscdn.com/avatar/1800007509477c92dfb?_k=1786009248482753345","TYPE Review  \nPUBLISHED 08 April 2024  \nDOI 10.3389/fcimb.2024.1374944  \nOPEN ACCESS  \nEDITED BY  \nSuhana Chattopadhyay,  \nUniversity of Maryland, College Park, United States  \nREVIEWED BY  \nMuhammad Akbar Shahid,  \nBahauddin Zakariya University, Pakistan Francesca Pirini,  \nScientific Institute of Romagna for the Study and Treatment of Tumors (IRCCS), Italy  \n*CORRESPONDENCE Yuanshan Cui  \n [doctorcuiys@163.com](doctorcuiys@163.com)[ ](doctorcuiys@163.com)Shu Liu  \n [zhong2010shan@163.com](zhong2010shan@163.com)  \n†These authors have contributed equally to this work and share first authorship  \nRECEIVED 23 January 2024  \nACCEPTED 26 March 2024  \nPUBLISHED 08 April 2024  \nCITATION  \nLou K, Chi J, Wu J, Ma J, Liu S and Cui Y (2024) Research progress on the microbiota in bladder cancer tumors.  \nFront. Cell. Infect. Microbiol. 14:1374944 .  \ndoi: 10.3389/fcimb.2024.1374944  \nCOPYRIGHT  \n© 2024 Lou, Chi, Wu, Ma, Liu and Cui. This isan open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nResearch progress on the microbiota in bladder cancer tumors  \nKeyuan Lou 1†, Junpeng Chi 1†, Jitao Wu 1, Jian Ma 1, Shu Liu 2* and Yuanshan Cui 1*  \n1 Department of Urology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China, 2 Department of Medical Oncology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China  \nThe microbiota, also referred to as the microbial community, is a crucial component of the human microenvironment. It is located predominantly in various organs, including the intestines, skin, oral cavity, respiratory tract, and reproductive tract. The microbiota maintains a symbiotic relationship with the human body, influencing physiological and pathological functions to a significant degree. There is increasing evidence linking the microbial flora to human cancers. In contrast to the traditional belief that the urethra and urine of normal individuals are sterile, recent advancements in high-throughput sequencing technology and bacterial cultivation methods have led to the discovery of specific microbial communities in the urethras of healthy individuals . Given the prevalence of bladder cancer (BCa) as a common malignancy of the urinary system, researchers have shifted their focus to exploring the connection between disease development and the unique microbial community within tumors. This shift has led to a deeper investigation into the role of microbiota in the onset, progression, metastasis, prognosis, and potential for early detection of BCa. This article reviews the existing research on the microbiota within BCa tumors and summarizes the findings regarding the roles of different microbes in various aspects of this disease.  \nKEYWORDS  \nbladder cancer, microbiota, review, prognosis, mechanism  \n1 Introduction  \nBladder cancer (BCa) ranks among the top ten most common urinary tract malignancies and is the second-most prevalent malignancy of the urinary system. It accounts for 4.6% of all new cancer diagnoses annually, with approximately 400,000 new cases and 160,000 deaths worldwide each year, and has a five-year mortality rate of 30%(Richters et al., 2020) . BCa can be divided into muscle-infiltrating bladder cancer (MIBC) and nonmuscle-infiltrating bladder cancer (NMIBC) based on its invasion into the muscular layer of the bladder wall (Lindskrog et al., 2021) . Approximately 70% of BCa  \nFrontiers in Cellular and Infection Microbiology 01 [frontiersin.org](frontiersin.org)  \ncases are NMIBC, while the remaining 30% are MIBC, which has a greater potential for invasion and metastasis (Grayson, 2017) . The ","cbCaibESmAbBeASF","https://ap.wps.com/l/cbCaibESmAbBeASF","pdf",1267112,13,"English","# Introduction\n## Bladder cancer overview and subtypes\n## Epidemiology and risk factors\n## Molecular alterations and diet-related carcinogenesis\n## Bladder microbiota in health and disease","[{\"question\":\"Why is the microbiota considered important for bladder cancer research?\",\"answer\":\"The microbiota is a crucial part of the human microenvironment and can influence physiological and pathological functions. Increasing evidence links microbial communities with human cancers, motivating study of their roles in bladder cancer.\"},{\"question\":\"How is bladder cancer (BCa) categorized in this review?\",\"answer\":\"Bladder cancer is divided into muscle-infiltrating bladder cancer (MIBC) and nonmuscle-infiltrating bladder cancer (NMIBC) based on invasion into the bladder wall muscular layer.\"},{\"question\":\"What topics does the review cover regarding microbiota in bladder cancer tumors?\",\"answer\":\"The review summarizes research on how different microbes may contribute to onset, progression, metastasis, prognosis, and the potential for early detection of BCa.\"}]","Research progress on the microbiota in bladder cancer tumors | PDF",1789989031,33]