[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-328334-105":59,"doc-detail-328334-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","research-progress-of-dna-methylation-in-colorectal-cancer-review","Research progress of DNA methylation in colorectal cancer - Review","","DNA methylation is an early, key epigenetic mechanism involving methyltransferase-catalyzed addition of methyl groups to specific DNA bases using S-adenosine methionine as the donor. DNA methylation contributes to cancer development, and site-specific methylation patterns can exert distinct effects. Colorectal cancer progression is influenced by methylation of crucial genes, shaping CRC development through regulation of key genetic events. Clinical relevance is emphasized through methylation-associated therapeutic targets and biomarkers, and the potential role of DNA methylation inhibitors as a treatment strategy.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/research-progress-of-dna-methylation-in-colorectal-cancer-review/328334/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/research-progress-of-dna-methylation-in-colorectal-cancer-review/328334.png","ImageObject",300,407,{"name":92,"@type":93},"Aria","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-09","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is DNA methylation and how does it occur?","Question",{"text":112,"@type":113},"DNA methylation is the addition of a methyl group to a specific base in DNA via DNA methyltransferase, using S-adenosine methionine as the methyl donor.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does DNA methylation affect colorectal cancer progression?",{"text":117,"@type":113},"Progression of colorectal cancer is affected by methylation of key genes, where methylation can influence CRC development by regulating those genes.",{"name":119,"@type":110,"acceptedAnswer":120},"Why is DNA methylation clinically important in colorectal cancer?",{"text":121,"@type":113},"Clinical significance lies in methylation-related therapeutic targets and biomarkers, and in considering DNA methylation inhibitors as a novel treatment strategy.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},328334,1790098473,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":41,"preview_page_count":4},2336464648322,"https://ap-avatar.wpscdn.com/avatar/2200025388227c56fec?_k=1778556882303663488","MOLECULAR MEDICINE REPORTS 30: 154, 2024  \nResearch progress of DNA methylation in colorectal cancer  \n(Review)  \nYUXIN WANG 1* , CHENGCHENG WANG2* , RUIQI ZHONG2 , LIANG WANG2 and LEI SUN 1  \n1Emergency Department, The Second Hospital of Dalian Medical University, Dalian, Liaoning 116027, P.R. China; 2Comparative Medicine Department of Researching and Teaching, Dalian Medical University, Dalian, Liaoning 116044, P.R. China  \nReceived March 28, 2024; Accepted June 14, 2024  \nDOI: 10. 3892/mmr.2024.13278  \nAbstract. DNA methylation is one of the earliest and most significant epigenetic mechanisms discovered. DNA meth‑ ylation refers, in general, to the addition of a methyl group to a specific base in the DNA sequence under the catalysis of DNA methyltransferase, with S‑adenosine methionine asthe methyl donor, via covalent bonding and chemical modi‑ fications. DNA methylation is an important factor in inducing cancer. There are different types of DNA methylation, and methylation at different sites plays different roles. It is well known that the progression of colorectal cancer (CRC) is affected by the methylation of key genes. The present review did not only discuss the potential relationship between DNA methylation and CRC but also discussed how DNA methyla‑ tion affects the development of CRC by affecting key genes. Furthermore, the clinical significance of DNA methylation in CRC was highlighted, including that of the therapeutic targetsand biomarkers of methylation; and the importance of DNA methylation inhibitors was discussed as a novel strategy for treatment of CRC. The present review did not only focus upon the latest research findings, but earlier reviews were also cited as references to older literature.  \nCorrespondence to: Professor Liang Wang, Comparative Medicine Department of Researching and Teaching, Dalian Medical University, 9 West Section of Lushun South Road, Lushunkou, Dalian, Liaoning 116027, P.R. China  \nE‑mail: wangliang‑[dy@dmu.edu.cn](dy@dmu.edu.cn)  \nDr Lei Sun, Emergency Department, The Second Hospital of Dalian Medical University, 465 Zhongshan Road, Shahekou, Dalian, Liaoning 116027, P.R. China  \nE‑mail: [sunlei20211013@163.com](sunlei20211013@163.com)  \n*Contributed equally  \nAbbreviations: CRC, colorectal cancer; CMS, common molecular subtypes; CIMP, CpG island methylation phenotype; SAM, s‑adenosylmethionine; DNMT, DNA methyltransferase; CIN, chromosomal instability; MSI, microsatellite instability; COX‑2, cyclooxygenase 2; TCM, Traditional Chinese Medicine  \nKey words: DNA methylation, CRC, therapeutic target, biomarker  \nContents  \n1. Introduction  \n2. DNA methylation  \n3. DNA methylation changes in several key genes in CRC  \n4. Clinical significance of DNA methylation in CRC  \n5. DNA methylation is an important therapeutic target for CRC  \n6. Conclusions and outlook  \n1. Introduction  \nColorectal cancer (CRC) is one of the common malignant tumors of the digestive tract, and its incidence is second only to that of gastric and esophageal cancers. CRC ranks fifth in men and sixth in women as a major cause of tumor‑related deaths in China . In the past 20 years, the morbidity of CRChas been on the rise, and the onset age has been increasing. In the western developed countries, CRC is the second most common malignancy after lung cancer. The incidence rate varies by up to 60 times in different countries. The sites most prone are the rectum and the junction between the rectum and sigmoid colon, accounting for 60% of the cancerous region. The incidence of CRC is related to various factors, such as eating habits, genetics and colitis. The disease is sporadic in most cases and usually indicates the joint effect of genes and environment, as only 20‑25% of patients demonstrated a family history. Only 5‑6% of CRC cases are attributed to genetic conditions and are referred to as the CRC genetic syndrome (1) . In recent years, the morbidity of colon cancer in western developed countries has demonstrated a de","cbCaih6pDMrcPFh7","https://ap.wps.com/l/cbCaih6pDMrcPFh7","pdf",2933883,12,"English","# Introduction\n## DNA methylation\n## DNA methylation changes in key genes in CRC\n## Clinical significance of DNA methylation in CRC\n## DNA methylation as a therapeutic target for CRC\n## Conclusions and outlook","[{\"question\":\"What is DNA methylation and how does it occur?\",\"answer\":\"DNA methylation is the addition of a methyl group to a specific base in DNA via DNA methyltransferase, using S-adenosine methionine as the methyl donor.\"},{\"question\":\"How does DNA methylation affect colorectal cancer progression?\",\"answer\":\"Progression of colorectal cancer is affected by methylation of key genes, where methylation can influence CRC development by regulating those genes.\"},{\"question\":\"Why is DNA methylation clinically important in colorectal cancer?\",\"answer\":\"Clinical significance lies in methylation-related therapeutic targets and biomarkers, and in considering DNA methylation inhibitors as a novel treatment strategy.\"}]","Research progress of DNA methylation in colorectal cancer - Review | PDF",1789979359]