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This opinion proposes repurposing methuosis-inducing anticancer drugs as anthelmintics, leveraging methuosis—a death marked by accumulation, coalescence, and rupture of large vacuoles. The article reviews methuosis-capable drugs that kill nematodes or cancer cells and summarizes structure–activity relationship insights for methuosis-inducing small molecules. The approach may enable broad-spectrum control and highlight shared molecular mechanisms across cancer and nematodes in response to these inducers.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/repurposing-methuosis-inducing-anticancer-drugs-for-anthelmintic-therapy/331252/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/repurposing-methuosis-inducing-anticancer-drugs-for-anthelmintic-therapy/331252.png","ImageObject",300,407,{"name":92,"@type":93},"Theodore","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-04","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What threat do drug-resistant parasitic nematodes create?","Question",{"text":112,"@type":113},"Drug-resistant parasitic nematodes endanger plants, animals, and humans, and they reduce the effectiveness of existing treatments.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What therapeutic strategy does the opinion propose?",{"text":117,"@type":113},"It proposes repurposing methuosis-inducing anticancer drugs as anthelmintics, targeting nematodes through methuosis-mediated cell death.",{"name":119,"@type":110,"acceptedAnswer":120},"How is methuosis described in the article?",{"text":121,"@type":113},"Methuosis is characterized by the formation of multiple tiny vacuoles that fuse into giant vacuoles, followed by rupture of the cuticle layer.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331252,1790871374,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},7971461740886,"https://ap-avatar.wpscdn.com/davatar_3d24733baf745e90a7e4bdd5f77d97b2","PLOS PATHOGENS  \nOPEN ACCESS  \nCitation: Rajasekharan SK, Ravichandran V, Boya BR, Jayachandran A, Lee J (2024) Repurposing methuosis-inducing anticancer drugs for anthelmintic therapy. PLoS Pathog 20(9):  \ne1012475 . [https://doi.org/10.1371/journal](https://doi.org/10.1371/journal). ppat.1012475  \nEditor: Laura J. Knoll, University of Wisconsin  \nMedical School, UNITED STATES OF AMERICA Published: September 5, 2024  \nCopyright: © 2024 Rajasekharan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.  \nFunding: The authors acknowledge the support from the management of SRMIST, Kattankulathur, Tamil Nadu, India. A part of the research was supported by the National Research Foundation of Korea (NRF) funded by the Korean government (MSIT) (2021R1A2C1008368) to JL and by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (RS-2024-00450423) to JL. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.  \nPEARLS  \nRepurposing methuosis-inducing anticancer drugs for anthelmintic therapy  \nSatish Kumar Rajasekharan1☯*, Vinothkannan Ravichandran2☯, Bharath Reddy Boya3, Anirudh Jayachandran1, Jintae Lee3 *  \n1 Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Chengalpattu District, Kattankulathur, Tamil Nadu, India, 2 Centre for Drug Discovery and Development (CD3), Amity Institute of Biotechnology, Amity University Maharashtra, Bhatan, Panvel, Mumbai, Maharashtra, India, 3 School of Chemical Engineering, Yeungnum University, Gyeongsan, Republic of Korea  \n☯ These authors contributed equally to this work.  \n* [satishkr2@srmist.edu.in](satishkr2@srmist.edu.in) (SKR); [jtlee@ynu.ac.kr](jtlee@ynu.ac.kr) (JL)  \nAbstract  \nDrug-resistant parasitic nematodes pose a grave threat to plants, animals, and humans. An innovative paradigm for treating parasitic nematodes is emphasized in this opinion. This approach relies on repurposing methuosis (a death characterized by accumulation of large vacuoles) inducing anticancer drugs as anthelmintics. We review drugs/chemicals that have shown to kill nematodes or cancerous cells by inducing multiple vacuoles that eventually coalesce and rupture. This perspective additionally offers a succinct summary on Structure–Activity Relationship (SAR) of methuosis-inducing small molecules. This strategy holds promise for the development of broad-spectrum anthelmintics, shedding light on shared molecular mechanisms between cancer and nematodes in response to these inducers, thereby potentially transforming both therapeutic domains.  \nA battle against parasitic nematodes  \nA nematode’s dynamic adaptability and simple body structure make it remarkably resilient to harsh environmental conditions. Disease and death caused by parasitic nematodes in humans, livestock, and plants are enormous [ 1] . In recent years, pathogenic nematodes have evolved to adapt to many lifestyles and have shown remarkable ability to expand their host range [2] . Consequently, they are becoming more resilient to environmental conditions, host responses, and anthelmintics. Three decades after its discovery, ivermectin and its derivatives are still widely used to control and eradicate nematodes [3] . Ivermectin derivatives, for instance, function by preferentially paralyzing the nematodes, making them inert and unable to reproduce [4] . However, a few parasitic nematodes have already developed resistance to ivermectin, and resistance to these anthelmintic treatments is likely to emerge in the future [5] . Furthermore, it is possible for resistance genes to disseminate within clades. Hence, research ought to concentrate ","cbCaioLaLo7fz7Nq","https://ap.wps.com/l/cbCaioLaLo7fz7Nq","pdf",1168697,"English","# Abstract\n# A battle against parasitic nematodes\n# Methuosis—A death by vacuolation","[{\"question\":\"What threat do drug-resistant parasitic nematodes create?\",\"answer\":\"Drug-resistant parasitic nematodes endanger plants, animals, and humans, and they reduce the effectiveness of existing treatments.\"},{\"question\":\"What therapeutic strategy does the opinion propose?\",\"answer\":\"It proposes repurposing methuosis-inducing anticancer drugs as anthelmintics, targeting nematodes through methuosis-mediated cell death.\"},{\"question\":\"How is methuosis described in the article?\",\"answer\":\"Methuosis is characterized by the formation of multiple tiny vacuoles that fuse into giant vacuoles, followed by rupture of the cuticle layer.\"}]","Repurposing methuosis-inducing anticancer drugs for anthelmintic therapy | PDF",1789992416,23]