[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-433760-105":59,"doc-detail-433760-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","repurposing-antihistamines-beyond-allergy-control-emerging-therapeutic-potentials-in-liver-cirrhosis-editorial","Repurposing antihistamines beyond allergy control: Emerging therapeutic potentials in liver cirrhosis - Editorial","","Histamine drives allergy-related inflammation via H1 receptors, but it also influences tissue fibrogenesis, vascular tone, and angiogenesis—processes central to liver cirrhosis, portal hypertension, and complications such as variceal bleeding. Evidence is discussed linking histamine to collagen synthesis, fibroblast proliferation, vasodilation, and VEGF- and angiogenesis-related pathways. The editorial highlights findings that the second-generation H1 antagonist levocetirizine lowers portal pressure, improves fibrosis severity in cirrhosis models, and may require careful monitoring of sedation risk and liver injury.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/repurposing-antihistamines-beyond-allergy-control-emerging-therapeutic-potentials-in-liver-cirrhosis-editorial/433760/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/repurposing-antihistamines-beyond-allergy-control-emerging-therapeutic-potentials-in-liver-cirrhosis-editorial/433760.png","ImageObject",300,407,{"name":92,"@type":93},"Aria","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",14,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"Why are H1 antihistamines considered beyond allergy control for liver cirrhosis?","Question",{"text":113,"@type":114},"The article explains that histamine participates not only in allergic inflammation but also in fibrogenesis, vascular changes, and angiogenesis, which contribute to cirrhosis and portal hypertension.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What effects of levocetirizine are highlighted in the editorial?",{"text":118,"@type":114},"Levocetirizine is reported to decrease portal pressure, ameliorate liver fibrosis severity, and reduce blood flow in key splanchnic vessels while increasing portal vein resistance in cirrhosis models.",{"name":120,"@type":111,"acceptedAnswer":121},"What clinical cautions are emphasized before using antihistamines in cirrhotic patients?",{"text":122,"@type":114},"The editorial stresses attention to sedation/drowsiness risk and to potential liver injury in patients with limited liver reserve, recommending close monitoring of mental status and liver function.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},433760,1790716715,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":14,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":24,"preview_page_count":4},2336464648322,"https://ap-avatar.wpscdn.com/avatar/2200025388227c56fec?_k=1778556882303663488","J Chin MedAssoc  \nEditorial  \nRepurposing antihistamines beyond allergy control: Emerging therapeutic potentials in liver cirrhosis  \nHui-Chun Huang*  \nFaculty of Medicine, Division of Endoscopy Diagnosis and Treatment and Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital and National Yang Ming Chiao Tung University School of Medicine, Taipei, Taiwan, ROC  \nHistamine is an active participant in the pathophysiological processes attributed to allergic reactions. It is mainly derived from mast cell degranulation and induces a cascade of reactions after binding to histamine receptors on different cells. Most of the major histamine actions related to allergy are mediated through the H1 receptor, including bronchoconstriction and vasodilation.1 H1 antihistamines, therefore, block the proinflammatory response elicited by histamine.2 The clinical use of H1 antihistamines was introduced in the 1940s. Since then, antihistamines have been used extensively for the control of various allergic conditions.  \nInterestingly, histamine also exerts various effects on tissue fibrogenesis, vascular tone, and angiogenesis. These features infact play pivotal roles in the pathogenesis of liver cirrhosis, portal hypertension, and the development of associated complications, such as gastroesophageal variceal bleeding. In terms of fibrogenesis, histamine has been known to stimulate collagen synthesis and fibroblast proliferation in keloid tissue3 as well as to induce vasodilation and protein-enriched exudate in peritoneal wounds. The exudate is the basis of abdominal adhesion and fibrosis.4 These findings were later confirmed by another animal study, showing that an antihistamine prevented abdominal postoperative adhesion.5 Regarding the vascular actions, histamine induces the H1 receptor–mediated vasorelaxation in the mesenteric arterial vascular bed.6 The similar finding is also reported in the coronary vasculature.7 The most remarkable finding is that histamine participates in splanchnic vasodilation and postprandial hyperemia,8 which is an contributory factor of elevated portal pressure and variceal hemorrhage in cirrhotic patients.9 Regarding histamine’s influence on angiogenesis increased release of histamine has been found in rapidly growing tissues, which is suggested to promote carcinogenesis and angiogenesis.10 This is supported by a previous study that histamine was mitogenic to human microvascular endothelial cells, which was stimulated by an H1-agonist and inhibited by H1-antagonist.11 Epinastine hydrochloride, a  \n*Address correspondence. Dr. Hui-Chun Huang, Faculty of Medicine, Division of Endoscopy Diagnosis and Treatment, Department of Medicine, Taipei Veterans General Hospital, 201 Shi-Pai Road, Section 2, Taipei 112, Taiwan, ROC. E-mail [addresses: hchuang2@gmail.com](addresses: hchuang2@gmail.com); [hchuang2@vghtpe.gov.tw](hchuang2@vghtpe.gov.tw) (H.-C. Huang). Conflicts of interest: Dr. Hui-Chun Huang, an editorial board member at the Journal of the Chinese Medical Association, had no role in the peer review process of or decision to publish this article.  \nJournal of Chinese Medical Association. (2025) 88: 897-898.  \nReceived October 11, 2025; accepted October 13, 2025. doi: 10. 1097/JCMA.0000000000001307  \nCopyright © 2025, the Chinese Medical Association. This is an open access article under the CC BY-NC-ND license ([http://creativecommons.org/licenses/](http://creativecommons.org/licenses/)[ ](http://creativecommons.org/licenses/)[by-nc-nd/4.0/](by-nc-nd/4.0/))  \nselective H1 antagonist, also significantly inhibited the release of vascular endothelial growth factor (VEGF) in murine mast cells.12 Sörbo et al,13 using the rat mesenteric window assay, also found that an H1 antagonist inhibited mast cell-mediated angiogenesis by interfering with the microvascular spatial expansion.  \nIn this issue, Chang et al14 reported that levocetirizine, a second-generation antihistamine that w","cbCaijAjZ4tR6Roe","https://ap.wps.com/l/cbCaijAjZ4tR6Roe","pdf",261064,"English","# Editorial\n## Histamine and H1 receptor mechanisms\n## Histamine in cirrhosis: fibrogenesis, vascular tone, angiogenesis\n## Levocetirizine and reported effects in cirrhosis models\n## Clinical considerations and safety monitoring","[{\"question\":\"Why are H1 antihistamines considered beyond allergy control for liver cirrhosis?\",\"answer\":\"The article explains that histamine participates not only in allergic inflammation but also in fibrogenesis, vascular changes, and angiogenesis, which contribute to cirrhosis and portal hypertension.\"},{\"question\":\"What effects of levocetirizine are highlighted in the editorial?\",\"answer\":\"Levocetirizine is reported to decrease portal pressure, ameliorate liver fibrosis severity, and reduce blood flow in key splanchnic vessels while increasing portal vein resistance in cirrhosis models.\"},{\"question\":\"What clinical cautions are emphasized before using antihistamines in cirrhotic patients?\",\"answer\":\"The editorial stresses attention to sedation/drowsiness risk and to potential liver injury in patients with limited liver reserve, recommending close monitoring of mental status and liver function.\"}]","Repurposing antihistamines beyond allergy control: Emerging therapeutic potentials in liver cirrhosis - Editorial | PDF",1790665384]