[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-375897-105":59,"doc-detail-375897-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","reprogramming-of-thyroid-cancer-metabolism-from-mechanism-to-therapeutic-strategy","Reprogramming of Thyroid Cancer Metabolism - from Mechanism to Therapeutic Strategy","","Thyroid cancer is a prevalent endocrine malignancy, and metabolism-based therapies have advanced quickly due to metabolic profiling. Tumor cells rewire numerous metabolic pathways to adapt to the tumor microenvironment. This review surveys recent progress in full-scale thyroid cancer metabolic rewiring and the connections among diverse metabolites, and it evaluates the efficacy and future prospects of metabolite-targeted detection and therapy. Understanding metabolic mechanisms and characteristics supports improved management of individual patients.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/reprogramming-of-thyroid-cancer-metabolism-from-mechanism-to-therapeutic-strategy/375897/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/reprogramming-of-thyroid-cancer-metabolism-from-mechanism-to-therapeutic-strategy/375897.png","ImageObject",300,407,{"name":92,"@type":93},"Maya Linwood","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is metabolism important for thyroid cancer research?","Question",{"text":112,"@type":113},"Metabolism drives essential cellular functions by balancing anabolism and catabolism. 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Molecular Cancer (2025) 24:74 [https://doi.org/10.1186/s12943-025-02263-4](https://doi.org/10.1186/s12943-025-02263-4)  \nMolecular Cancer  \n REVIEW Open Access  \nReprogramming of Thyroid Cancer Metabolism: from Mechanism to Therapeutic Strategy  \nYuxuan Wan1,2, Guoqing Li1,2, Gaoyuan Cui2, Saili Duan1,2,3* and Shi Chang1,4,5,6*  \nAbstract  \nThyroid cancer as one of the most prevalent malignancies of endocrine system, has raised public concern and more research on its mechanism and treatment. And metabolism-based therapies have advanced rapidly, for the exclusive metabolic profiling of thyroid cancer. In thyroid cancer cells, plenty of metabolic pathways are reprogrammed to accommodate tumor microenvironment. In this review, we initiatively summarize recent progress in the full-scale thyroid cancer metabolic rewiring and the interconnection of various metabolites. We also discuss the efficacy and prospect of metabolic targeted detection as well as therapy. Comprehending metabolic mechanism and characteristics of thyroid cancer roundly will be highly beneficial to managing individual patients.  \nKeywords Thyroid cancer, Metabolism, Genetics, Carcinogenesis, Diagnosis, Targeted therapy  \nIntroduction  \nMetabolism includes a series of chain reactions converting nutrients intake into energy as well as producing structural components such as protein and nucleic acids [1]. It is essential for every cell of living organisms to maintain basic functions, which rely on the balance  \n*Correspondence:  \nSaili Duan [sailid@med.umich.edu](sailid@med.umich.edu)[ ](sailid@med.umich.edu)Shi Chang [changshi@csu.edu.cn](changshi@csu.edu.cn)  \n1 Department of General Surgery, Xiangya Hospital Central South University, Changsha 410008, Hunan, People’s Republic of China  \n2 Xiangya School of Medicine, Central South University, Changsha 410008, Hunan, People’s Republic of China  \n3 Department of Cancer Biology, University of Michigan, Ann Arbor, MI 48109, USA  \n4 National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha 410008, Hunan, People’s Republic of China  \n5 Clinical Research Center for Thyroid Disease in Hunan Province, Changsha 410008, Hunan, People’s Republic of China  \n6 Hunan Provincial Engineering Research Center for Thyroid and Related Diseases Treatment Technology, Changsha 410008, Hunan, People’s Republic of China  \nbetween anabolism (synthesis) and catabolism (degradation) [2]. We usually call glucose, lipids and amino acids“fuels” in our body because they can be oxidated and produce a large amount of adenosine 5’-triphosphate (ATP) for energy supply [3, 4]. Among the energy-supplying substances, glucose and lipids serve as the major sources of energy in our body, and in most cases, glucose oxidation keeps the priority [5]. These principles guarantee that cellular metabolism could generate enough ATP with the maximum efficiency. As is widely proved, energy demands vary by organs and tissues, as well as their metabolic status. For instance, the brain energy consumption accounts for over 20% of the total in order to coordinate with neural activities [6–8] and the skeletal muscles can quickly activate metabolic pathways for ATP synthesis during exercise [9]. In cancer cells, the overall metabolism is reprogrammed so significantly that the malignantly mutated and proliferating cells are able to survive in a low-nutrient and acidic milieu [10]. They form a new metabolic network, in which biosynthesis, electron carrier regeneration and metabolic control are comprehensively redirected, to support the high-speed growth of  \nThis is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2025. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and ","cbCaieS4h4VZRlL9","https://ap.wps.com/l/cbCaieS4h4VZRlL9","pdf",2467101,"English","# Abstract\n# Keywords\n# Introduction\n## Metabolism as a cellular foundation\n## Cancer metabolism reprogramming\n## Thyroid cancer overview","[{\"question\":\"Why is metabolism important for thyroid cancer research?\",\"answer\":\"Metabolism drives essential cellular functions by balancing anabolism and catabolism. In cancer cells, metabolism is reprogrammed to survive under low nutrients and acidic conditions, supporting rapid growth and malignancy.\"},{\"question\":\"What does the review focus on regarding metabolic rewiring?\",\"answer\":\"It summarizes recent progress in comprehensive thyroid cancer metabolic rewiring and the interconnection of various metabolites. It also discusses how these metabolic changes relate to tumor behavior and treatment approaches.\"},{\"question\":\"How can metabolism-based strategies contribute to thyroid cancer management?\",\"answer\":\"The review discusses metabolic targeted detection and therapy, emphasizing that understanding metabolic mechanisms and characteristics can be highly beneficial for managing individual patients.\"}]","Reprogramming of Thyroid Cancer Metabolism - from Mechanism to Therapeutic Strategy | PDF",1790216558,76]