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The authors address the critic’s statements regarding hypogonadism and vitamin D deficiency, clarifying that the discussion relates to prevalence and incidence within an insurance database framework. They emphasize baseline inclusion status and endpoint event occurrence, so cases without key conditions at baseline or events at endpoint are classified as not having such events.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/reply-to-is-it-real-of-lower-incidence-of-vitamin-d-deficiency-in-t2dm-patients-letter-to-the-editor/436487/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/reply-to-is-it-real-of-lower-incidence-of-vitamin-d-deficiency-in-t2dm-patients-letter-to-the-editor/436487.png","ImageObject",300,407,{"name":92,"@type":93},"Kyle","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-06","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What question does this letter address?","Question",{"text":113,"@type":114},"It replies to whether lower incidence of vitamin D deficiency in T2DM patients is real.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How do the authors interpret the data on hypogonadism and vitamin D deficiency?",{"text":118,"@type":114},"They distinguish between prevalence rate and incidence rate and explain how the study determines these based on baseline and endpoint conditions.",{"name":120,"@type":111,"acceptedAnswer":121},"Why might some research cases be considered as not having hypogonadism or vitamin D deficiency?",{"text":122,"@type":114},"If the condition is absent at baseline inclusion or no related event occurs by the endpoint, the case is treated as not having such events in the analysis.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},436487,1790792055,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":81,"preview_page_count":4},3985741905716,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","J Chin MedAssoc  \nLETTER TO THE EDITOR  \nReply to “Is it real of lower incidence of vitamin D deficiency in T2DM patients?”  \nChia-Hao Changa, Chieh-Hua Lub,c, Chang-Hsun Hsiehb, Wu-Chien Chienc,d,e,*  \naDivision of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Armed Forces General Hospital, Taichung, Taiwan, ROC; bDivision of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan, ROC; cDepartment of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC; dSchool of Public Health, National Defense Medical Center, Taipei, Taiwan, ROC; eTaiwanese Injury Prevention and Safety Promotion Association, Taipei, Taiwan, ROC  \nDEAR EDITOR,  \nWe thank Dr. Yiu-Tai Li, Szu-Ting Yang, and Peng-Hui Wang for the valuable comments and questions1 on our study named“Dipeptidyl peptidase-4 inhibitors attenuates osteoporosis inpatients with diabetes: A nationwide, retrospective, matchedcohort study in Taiwan” published in Journal of the Chinese Medical Association in July 2022.2 The author comments are discussed below.  \nThe data on hypogonadism and vitamin D deficiency proposed by the author are the prevalence rate or the incidence rate. The health insurance database must have the above-mentioned reasons to seek medical treatment before it can be caught. The main reason should be: Our comorbidities are “now” situations. That is, Baseline (inclusion date), whether Endpoint currently has hypogonadism, vitamin D deficiency diagnostic code. In other words, even if  \nthe research case has hypogonadism, vitamin D deficiency, or in the research process, but there is no key at the time of the included analysis (Baseline) or the occurrence of Events (Endpoint), this research will be regarded as not having such events.  \nWe hope these explanations will suffice the readers’ and the authors’ expectations. Thank you for your interest again.  \nREFERENCES  \n1. Li YT, Yang ST, Wang PH. Is it real of lower incidence of vitamin D deficiency in T2DM patients? J Chin Med Assoc. 2022;85:958 .  \n2. Chang CH, Lu CH, Chung CH, Su SC, Kuo FC, Liu JS, et al. Dipeptidylpeptidase-4 inhibitors attenuates osteoporosis in patients with diabetes: a nationwide, retrospective, matched-cohort study in Taiwan. J Chin Med Assoc 2022;85:747–53 .  \n*Address correspondence. Dr. Wu-Chien Chien, Department of Medical Research, Tri-Service General Hospital, National Defense Medical Center,  \n325, Section 2, Cheng-Kung Road, Taipei 114, Taiwan, ROC. E-mail address: [chienwu@mail.ndmctsgh.edu.tw](chienwu@mail.ndmctsgh.edu.tw) (W.-C. Chien).  \nConflicts of interest: The authors declare that they have no conflicts of interest related to the subject matter or materials discussed in this article.  \nJournal of Chinese Medical Association. (2022) 85: 960.  \nReceived July 12, 2022; accepted July 18, 2022.  \ndoi: 10. 1097/JCMA.0000000000000787.  \nCopyright © 2022, the Chinese Medical Association. This is an open access article under the CC BY-NC-ND license ([http://creativecommons.org/licenses/](http://creativecommons.org/licenses/)[ ](http://creativecommons.org/licenses/)[by-nc-nd/4.0/](by-nc-nd/4.0/))  \n960 [www.ejcma.org](www.ejcma.org)  \n\u003Czdoi: 10.1097/JCMA.0000000000000787>","cbCaisZP8OKgK0zk","https://ap.wps.com/l/cbCaisZP8OKgK0zk","pdf",280408,"English","# Letter to the Editor\n## Response to authors’ comments\n## Data definitions and baseline/endpoint handling\n## References and publication details","[{\"question\":\"What question does this letter address?\",\"answer\":\"It replies to whether lower incidence of vitamin D deficiency in T2DM patients is real.\"},{\"question\":\"How do the authors interpret the data on hypogonadism and vitamin D deficiency?\",\"answer\":\"They distinguish between prevalence rate and incidence rate and explain how the study determines these based on baseline and endpoint conditions.\"},{\"question\":\"Why might some research cases be considered as not having hypogonadism or vitamin D deficiency?\",\"answer\":\"If the condition is absent at baseline inclusion or no related event occurs by the endpoint, the case is treated as not having such events in the analysis.\"}]","Reply to \"Is it real of lower incidence of vitamin D deficiency in T2DM patients?\" - Letter to the Editor | PDF",1790678150]