[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-434506-105":59,"doc-detail-434506-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","reply-reframing-the-ozonelung-cancer-link-toward-exposure-equity-in-urban-china","Reply: reframing the ozone–lung cancer link - toward exposure equity in urban China","","Letter reply to editor addressing comments on a recent study examining long-term ozone exposure and lung cancer incidence in China. The authors discuss individualized exposure measurement and its cohort-scale implementation challenges, explain how registry regions meeting quality standards were selected while noting the value of additional completeness and sensitivity analyses, and contrast their large population cohort approach with prior ecological studies. They call for evidence-based air quality policies and more refined spatial diagnostics to advance exposure equity.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/reply-reframing-the-ozonelung-cancer-link-toward-exposure-equity-in-urban-china/434506/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/reply-reframing-the-ozonelung-cancer-link-toward-exposure-equity-in-urban-china/434506.png","ImageObject",300,407,{"name":92,"@type":93},"Sarah ","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":24},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What does the reply say about individualized ozone exposure measurement?","Question",{"text":112,"@type":113},"The authors state that individualized measurement can assess ozone exposure more precisely at the individual level, but it depends on continuous tracking of personal mobility trajectories, making large-cohort implementation challenging.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were regions selected for the registry-based evaluation?",{"text":117,"@type":113},"Regions were specifically chosen where local cancer registries consistently meet appropriate quality standards, aiming to reduce bias from under-reporting and improve the reliability of outcomes.",{"name":119,"@type":110,"acceptedAnswer":120},"What future research directions are proposed?",{"text":121,"@type":113},"The authors suggest using more sensitive ozone-related spatial diagnostics and adjusting for additional residential-environment and lifestyle risk factors to better investigate patterns of second-order environmental injustice.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},434506,1791300722,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":24,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":14,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":24,"preview_page_count":4},962085320529,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","Journal of the National Cancer Center 5 (2025) 549–550  \nContents lists available at ScienceDirect  \nJournal of the National Cancer Center  \njournal [homepage:](homepage: www.elsevier.com/locate/jncc)[ www.elsevier.com/locate/jncc](homepage: www.elsevier.com/locate/jncc)  \nLetter  \nReply: reframing the ozone–lung cancer link: toward exposure equity in urban China  \nTo the editor,  \nWe sincerely appreciate the thoughtful and constructive comments from the authors of the letter regarding our recent publication on longterm ozone (O3 ) exposure and the incidence of lung cancer in China.1 , 2 Their insights raise important considerations for future research in environmental oncology, and we would like to respond to the key points raised.  \nFirst, the individualized measurement method mentioned by the authors represents a more precise method for assessing ozone exposure, as it enables a detailed characterization of exposure at the individual level to environmental factors. Nonetheless, it is important to acknowledge that this method fundamentally relies on continuous monitoring of personal mobility patterns, necessitating accurate tracking of individual movement trajectories. Although this approach enhances accuracy, its practical implementation in large cohorts presents considerable challenges due to the extensive data collection and processing demands required to monitor personal mobility across a large population. Therefore, despite the methodological advantages of individualized measurements, their use in large-scale cohort studies is inherently constrained. We really appreciate the authors’ recommendations concerning the ozone concentration estimation models and intend to enhance the precision of exposure assessment in subsequent studies with comparatively smaller sample sizes.  \nSecond, following an evaluation conducted by the National Central Cancer Registry, we specifically selected regions where local registries consistently meet the appropriate quality standards.3 These selected areas are characterized by a low probability of under-reporting and are considered to provide relatively reliable data, thereby minimizing the influence of incomplete reporting on the study outcomes. However, we concur that further reporting of registry completeness, timeliness, and regional variation would enhance transparency and interpretability, especially in SES-stratified or geographic subgroup analyses. We will consider including registry quality indicators and corresponding sensitivity analyses in subsequent publications.  \nThird, compared to previous ecological studies conducted in this field, our research, based on a large population cohort, has collected more comprehensive data on individuals’ socioeconomic and behavioral characteristics. This more detailed methodological approach facilitatesan in-depth investigation of the potential interactions between environmental determinants and individual characteristics, thereby yielding a more sophisticated comprehension of the association between exposure and health outcomes. We fully acknowledge and value the insightful perspective offered by the reviewer. Although current data limitations preclude adjustment for certain urban development-related risk factors—such as those about infrastructure, industrialization, or urban planning—we recognize the critical role these elements play in influencing both environmental exposures and health outcomes. We hope that  \nfuture research will use more sensitive ozone-related spatial diagnosticsand adjust for more detailed risk factors related to the residential environment and lifestyle patterns to uncover more refined patterns related to the second-order environmental injustice mentioned by the authors.  \nOnce again, we thank the authors for their valuable perspectives. As emphasized in both the letter and our paper, reclassifying ozone as a key carcinogenic threat and integrating it into public health strategies is a critical next step. We hope our findings can ","cbCaisS8ZPHOtHqk","https://ap.wps.com/l/cbCaisS8ZPHOtHqk","pdf",264978,"English","# Letter\n## Reply to key points\n## Competing interest and author contributions","[{\"question\":\"What does the reply say about individualized ozone exposure measurement?\",\"answer\":\"The authors state that individualized measurement can assess ozone exposure more precisely at the individual level, but it depends on continuous tracking of personal mobility trajectories, making large-cohort implementation challenging.\"},{\"question\":\"How were regions selected for the registry-based evaluation?\",\"answer\":\"Regions were specifically chosen where local cancer registries consistently meet appropriate quality standards, aiming to reduce bias from under-reporting and improve the reliability of outcomes.\"},{\"question\":\"What future research directions are proposed?\",\"answer\":\"The authors suggest using more sensitive ozone-related spatial diagnostics and adjusting for additional residential-environment and lifestyle risk factors to better investigate patterns of second-order environmental injustice.\"}]","Reply: reframing the ozone–lung cancer link - toward exposure equity in urban China | PDF",1790669635]