[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-30945":3,"doc-seo-30945":21},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"file_id":15,"file_url":16,"file_type":17,"file_size":18,"view_count":4,"is_deleted":4,"is_public":19,"is_downloadable":19,"audit_status":19,"update_tm":20},30945,1374391974564,"Clementine","https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd",7,"Healthcare","Reperfusion Injury And Amiodarone Notes","Clinical physiology and pharmacology notes cover reperfusion injury following restoration of blood flow after ischemia. Reversibly injured cells may recover, while damaged cells can die rapidly via apoptosis or necrosis through mechanisms including oxygen free radical generation, mitochondrial permeability transition with severe irreversible mitochondrial damage, inflammation recruiting neutrophils, and complement pathway activation causing further injury. Cardiac, brain, or skeletal muscle damage can lead to creatine kinase leakage, while cellular swelling, glutathione peroxidase activity, mitochondrial vacuolization, and nuclear changes distinguish reversible from irreversible injury. Additional content describes myocardial infarction healing stages, emphasizing collagen deposition and type I collagen. Amiodarone notes explain class III antiarrhythmic actions on potassium channels, phase 3 effects, QT prolongation implications, and torsades de pointes risk characteristics.","cbCaim1cRL5utE1t","https://ap.wps.com/l/cbCaim1cRL5utE1t","pdf",67930682,1,1778363761,{"code":4,"msg":22,"data":23},"ok",{"site_id":24,"language":25,"slug":26,"title":13,"keywords":27,"description":14,"schema_data":28,"social_meta":62,"head_meta":64,"extra_data":66,"updated_unix":20},105,"en","reperfusion-injury-and-amiodarone-notes","",{"@graph":29,"@context":61},[30,47],{"@type":31,"itemListElement":32},"BreadcrumbList",[33,37,41,44],{"item":34,"name":35,"@type":36,"position":19},"https://docshare.wps.com","Home","ListItem",{"item":38,"name":39,"@type":36,"position":40},"https://docshare.wps.com/document/","Document",2,{"item":42,"name":12,"@type":36,"position":43},"https://docshare.wps.com/document/healthcare/",3,{"item":45,"name":13,"@type":36,"position":46},"https://docshare.wps.com/document/reperfusion-injury-and-amiodarone-notes/30945",4,{"url":45,"name":13,"@type":48,"author":49,"headline":13,"publisher":51,"fileFormat":54,"description":14,"dateModified":55,"datePublished":55,"encodingFormat":54,"isAccessibleForFree":56,"interactionStatistic":57},"DigitalDocument",{"name":9,"@type":50},"Person",{"url":34,"name":52,"@type":53},"DocShare","Organization","application/pdf","2026-05-09",true,{"@type":58,"interactionType":59,"userInteractionCount":4},"InteractionCounter",{"@type":60},"ViewAction","https://schema.org",{"og:url":45,"og:type":63,"og:title":13,"og:site_name":52,"og:description":14},"article",{"robots":65,"canonical":45},"index,follow",{"doc_id":7,"site_id":24}]