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The analysis highlights LoY as a possible early indicator of cancer behavior, supporting exploration of diagnostic tools and emerging therapeutic approaches linked to Y-chromosome alterations.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & 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Chromosome and Urologic Cancers: New Future Perspectives  \nPierluigi Russo 1,2, Francesco Pio Bizzarri 1,2,3,4, Giovanni Battista Filomena 1,2,5, *, Filippo Marino 1,2,4, Roberto Iacovelli 6, Chiara Ciccarese 6, Luigi Boccuto 7, Mauro Ragonese 1, Filippo Gavi 1,2,  \nFrancesco Rossi 1,2,3, Cosimo Savoia 8, Paolo Pietro Suraci 9, Roberto Falabella 10, Savio Domenico Pandolfo 11, Luigi Napolitano 11, Chiara Leoni 12, Valentina Trevisan 12, Giuseppe Palermo 1, Marco Racioppi 1,2, Emilio Sacco 2,3, Stijn Muselaers 13 and Nazario Foschi 1  \nCitation: Russo, P.; Bizzarri, F.P.; Filomena, G.B.; Marino, F.; Iacovelli, R.; Ciccarese, C.; Boccuto, L.; Ragonese, M.; Gavi, F.; Rossi, F.; et al. Relationship Between Loss of Y Chromosome and Urologic Cancers: New Future Perspectives. Cancers 2024, 16, 3766 . [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)cancers16223766  \nAcademic Editor: Gail Risbridger  \nReceived: 25 September 2024  \nRevised: 27 October 2024  \nAccepted: 28 October 2024  \nPublished: 8 November 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Department of Urology, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, 00168 Rome, Italy; [pierluigi.russo1@guest.policlinicogemelli.it or pierluigi.russo@radboudumc.nl](pierluigi.russo1@guest.policlinicogemelli.it or pierluigi.russo@radboudumc.nl) (P.R.); [giuseppe.palermo@policlinicogemelli.it](giuseppe.palermo@policlinicogemelli.it) (G.P.); [nazario.foschi@policlinicogemelli.it](nazario.foschi@policlinicogemelli.it) (N.F.)  \n2 Department of Urology, Università Cattolica Del Sacro Cuore, 00168 Rome, Italy  \n3 Department of Urology, Ospedale Isola Tiberina—Gemelli Isola, 00168 Rome, Italy  \n4 Department of Urology, Addenbrooke’s Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK  \n5 Department of Urology,“F. Miulli” General Hospital, 70021 Acquaviva Delle Fonti, BA, Italy  \n6 Department of Oncology, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, 00168 Rome, Italy  \n7 Healthcare Genetics and Genomics, School of Nursing, Clemson University, Clemson, SC 29634, USA  \n8 Section of Hygiene, University Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, 00168 Rome, Italy  \n9 Unit of Urology, Department of Medical-Surgical Sciences and Biotechnologies, Istituto Chirurgico Ortopedico Traumatologico Hospital, University of Rome Sapienza, Via F. Faggiana 1668, 04100 Latina, Italy  \n10 Azienda Ospedaliera San Carlo, 85100 Potenza, Italy  \n11 Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples“Federico II”, 80138 Naples, Italy  \n12 Center for Rare Diseases and Birth Defects, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Rome, Italy  \n13 Department of Urology, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands  \n* [Correspondence: giovanni.filomena17@gmail.com](Correspondence: giovanni.filomena17@gmail.com)  \nSimple Summary: This research examines how the loss of the Y chromosome (LoY) in men may contribute to the development and progression of certain cancers, particularly in the urinary system. Traditionally, the Y chromosome was primarily associated with male sex determination and sperm production, but recent studies suggest it plays a wider role in health and disease. LoY appears to disrupt immune function and increase genetic instability, factors that may heighten cancer risk and impact treatment outcomes. Our review highlights that LoY could serve as an early indicator of certain ca","cbCaimoRKoNQVga1","https://ap.wps.com/l/cbCaimoRKoNQVga1","pdf",630897,16,"English","# Simple Summary\n## Research focus and implications\n# Abstract\n## Background\n## Methods\n## Results\n## Conclusions\n# Keywords\n# Introduction","[{\"question\":\"What does the review focus on regarding the Y chromosome?\",\"answer\":\"The review focuses on how loss of the Y chromosome (LoY) may contribute to the development and progression of certain cancers, particularly urologic cancers.\"},{\"question\":\"What methods were used to gather evidence?\",\"answer\":\"A comprehensive literature review was conducted using MEDLINE, Scopus, Web of Science, and Google Scholar, including clinical and preclinical studies in animals and humans.\"},{\"question\":\"How might LoY influence cancer outcomes?\",\"answer\":\"The evidence suggests LoY is associated with increased risk of urologic neoplasms and correlates with worse survival outcomes, potentially through mechanisms involving genomic instability and effects on chromatin and epigenetic regulation.\"}]","Relationship Between Loss of Y Chromosome and Urologic Cancers: New Future Perspectives - Review | PDF",1789999529]