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Methods: a retrospective institutional review board–approved study included 76 women with surgically proven breast cancers who underwent DCE MRI with an ultrafast sequence; patients were grouped as low-TILs (\u003C10%) or high-TILs (≥10%). Maximum slope (MS) and time to enhancement (TTE) from ultrafast DCE were analyzed, and six conventional DCE kinetic pattern percentages were correlated with TILs level. Results show higher MS and shorter TTE in high-TILs, with modest ROC discrimination; conventional kinetic pattern percentages did not differ significantly. Conclusion links high TILs with faster enhancement and greater early-phase kinetic activity.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/relationship-between-kinetic-parameters-of-ultrafast-dynamic-contrast-enhanced-dce-mri-and-tumor-infiltrating-lymphocytes-tils-in-breast-cancer/338637/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/relationship-between-kinetic-parameters-of-ultrafast-dynamic-contrast-enhanced-dce-mri-and-tumor-infiltrating-lymphocytes-tils-in-breast-cancer/338637.png","ImageObject",300,407,{"name":92,"@type":93},"Aurelia","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-28","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the study purpose regarding TILs and ultrafast DCE MRI?","Question",{"text":112,"@type":113},"To evaluate the relationship between kinetic parameters from ultrafast dynamic contrast-enhanced (DCE) MRI and tumor-infiltrating lymphocytes (TILs) in breast cancer.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were patients grouped in this retrospective study?",{"text":117,"@type":113},"The study classified 76 women with surgically proven breast cancers into a low-TILs group (\u003C10%) and a high-TILs group (≥10%) based on TILs level.",{"name":119,"@type":110,"acceptedAnswer":120},"Which ultrafast DCE kinetic parameters were analyzed, and what were the main findings?",{"text":121,"@type":113},"Maximum slope (MS) and time to enhancement (TTE) from ultrafast DCE were correlated with TILs level. High-TILs cancers showed significantly higher MS and significantly shorter TTE, with ROC AUC values around 0.661 and 0.685.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},338637,1790108116,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":46},1099514068365,"https://ap-avatar.wpscdn.com/avatar/10000253d8d9f28188e?_k=1776742907772140068","Japanese Journal of Radiology (2025) 43:43–50  \n[https://doi.org/10.1007/s1](https://doi.org/10.1007/s1) 1604-024-01645-w  \nRelationship between kinetic parameters of ultrafast dynamic contrast‑enhanced (DCE) MRI and tumor‑infiltrating lymphocytes (TILs) in breast cancer  \nKen Yamaguchi1 · Takahiko Nakazono1 · Ryoko Egashira1 · Shuichi Fukui1 · Tsutomu Imaizumi1 · Katsuya Maruyama2 · Dominik Nickel3 · Takahiro Hamamoto4 · Rin Yamaguchi5 · Hiroyuki Irie1  \nReceived: 9 April 2024 / Accepted: 15 August 2024 / Published online: 26 August 2024 © The Author(s) 2024  \nAbstract  \nPurpose To evaluate the relationship between kinetic parameters of ultrafast dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) and tumor-infiltrating lymphocytes (TILs) in breast cancer.  \nPatients and methods This retrospective study was approved by an institutional review board and included 76 women (median age: 60) with 76 surgically proven breast cancers who underwent DCE MRI including ultrafast sequence. Based on the TILs level, we classified the patients into the low-TILs (\u003C 10%) group and the high-TILs (≥ 10%) group. Maximum slope (MS) and time to enhancement (TTE) derived from ultrafast DCE sequence were correlated in each TILs group. The percentages of six kinetic patterns (fast, medium, and slow from the early phase, washout, plateau, and persistent from the delayed phase) derived from the conventional DCE sequence were also correlated in each TILs group.  \nResults Of the 76 breast cancers, 57 were in the low-TILs group and 19 comprised the high-TILs group. The median MS in the high-TILs group (32.4%/sec) was significantly higher than that in the low-TILs group (23.68%/s) (p = 0.037) . In a receiveroperating characteristic (ROC) analysis, the area under the curve (AUC) for differentiating between the high-and low-TILs group was 0.661. The TTE in the high-TILs group was significantly shorter than that in the low-TILs group (p = 0.012) . In the ROC analysis, the AUC was 0.685. There were no significant differences between the percentages of the six kinetic patterns from the conventional DCE sequence and the TILs level (p = 0.075–0.876) .  \nConclusion Compared to the low-TILs group, the high-TILs group had higher MS and shorter TTE.  \nKeywords Breast cancer · Magnetic resonance imaging · Ultrafast · TILs · Prognosis  \n* Ken Yamaguchi [yamaguk@cc.saga-u.ac.jp](yamaguk@cc.saga-u.ac.jp)  \nTakahiko Nakazono  \n[nakazot@cc.saga-u.ac.jp](nakazot@cc.saga-u.ac.jp)  \nRyoko Egashira  \n[egashira@cc.saga-u.ac.jp](egashira@cc.saga-u.ac.jp)  \nShuichi Fukui  \n[saga.fukui44@gmail.com](saga.fukui44@gmail.com)  \nTsutomu Imaizumi  \n[imaizumt@cc.saga-u.ac.jp](imaizumt@cc.saga-u.ac.jp)  \nKatsuya Maruyama  \n[katsuya.maruyama@siemens-healthineers.com](katsuya.maruyama@siemens-healthineers.com)[ ](katsuya.maruyama@siemens-healthineers.com)Dominik Nickel [marcel.nickel@siemens-healthineers.com](marcel.nickel@siemens-healthineers.com)  \nTakahiro Hamamoto  \n[hamamoto@ajisaiclinic.com](hamamoto@ajisaiclinic.com)  \nRin Yamaguchi  \n[rin@med.kurume-u.ac.jp](rin@med.kurume-u.ac.jp)  \nHiroyuki Irie  \n[irie@cc.saga-u.ac.jp](irie@cc.saga-u.ac.jp)  \n1 Department of Radiology, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan  \n2 MR Research & Collaboration Department, Siemens Healthcare K.K., Gate City Osaki West Tower, 1-11-1 Osaki, Shinagawa-Ku, Tokyo 141-8644, Japan  \n3 MR Application Development, Siemens Healthcare GmbH, Allee Am Roethelheimpark 2, 91052 Erlangen, Germany  \n4 Ajisai Clinic, 1-9-38 Ekimaechuo, Saga 840-0801, Japan  \n5 Department of Pathology and Laboratory Medicine, Kurume University Medical Center, 155-1 Kokubu, Kurume 859-0863, Japan  \nIntroduction  \nBreast cancer is the most frequent cancer in women worldwide [1] . Some breast cancers are rich in lymphocytes and plasma cells, and these cancers are known to have a good prognosis [2] . Tumor-infiltrating lymphocytes (TILs) area new biomarker for the prognosis and the chemothera","cbCaimXqVyidGO4J","https://ap.wps.com/l/cbCaimXqVyidGO4J","pdf",1192035,"English","# Abstract\n## Purpose\n## Patients and methods\n## Results\n## Conclusion\n# Introduction\n## TILs as a prognostic and predictive biomarker\n## Imaging evaluation of TILs and prior DCE/DWI/radiomics studies\n## Rationale for using ultrafast DCE kinetics","[{\"question\":\"What is the study purpose regarding TILs and ultrafast DCE MRI?\",\"answer\":\"To evaluate the relationship between kinetic parameters from ultrafast dynamic contrast-enhanced (DCE) MRI and tumor-infiltrating lymphocytes (TILs) in breast cancer.\"},{\"question\":\"How were patients grouped in this retrospective study?\",\"answer\":\"The study classified 76 women with surgically proven breast cancers into a low-TILs group (\\u003c10%) and a high-TILs group (≥10%) based on TILs level.\"},{\"question\":\"Which ultrafast DCE kinetic parameters were analyzed, and what were the main findings?\",\"answer\":\"Maximum slope (MS) and time to enhancement (TTE) from ultrafast DCE were correlated with TILs level. High-TILs cancers showed significantly higher MS and significantly shorter TTE, with ROC AUC values around 0.661 and 0.685.\"}]","Relationship between kinetic parameters of ultrafast dynamic contrast-enhanced (DCE) MRI and tumor-infiltrating lymphocytes (TILs) in breast cancer | PDF",1790024710]