[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-373294-105":59,"doc-detail-373294-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","relationship-between-abo-blood-group-antigens-and-rh-factor-with-breast-cancer-a-systematic-review-and-meta-analysis","Relationship between ABO blood group antigens and Rh factor with breast cancer - A systematic review and meta-analysis","","Systematic review and meta-analysis evaluating the relationship between ABO blood group antigens, Rh factor, and breast cancer risk. The study addresses inconsistent findings across prior research by synthesizing evidence from case-control studies and quantifying associations using relative risk and odds ratio with 95% confidence intervals. Results report that blood type A shows a statistically significant link to breast cancer, whereas blood types B and AB and the Rh factor show no significant association. Findings support further research on underlying mechanisms.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/relationship-between-abo-blood-group-antigens-and-rh-factor-with-breast-cancer-a-systematic-review-and-meta-analysis/373294/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/relationship-between-abo-blood-group-antigens-and-rh-factor-with-breast-cancer-a-systematic-review-and-meta-analysis/373294.png","ImageObject",300,407,{"name":92,"@type":93},"WPS_1786070896","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-24","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":19},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the primary objective of the systematic review?","Question",{"text":112,"@type":113},"To summarize and analyze available evidence to produce comprehensive, accurate information that supports evidence-based decisions about the relationship between blood groups and breast cancer.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which blood group showed a significant association with breast cancer?",{"text":117,"@type":113},"Blood type A showed an association with breast cancer (OR = 1.18, 95% CI: 1.03–1.36) compared with blood type O.",{"name":119,"@type":110,"acceptedAnswer":120},"How were outcomes measured and which databases were searched?",{"text":121,"@type":113},"Outcomes were presented as relative risk and odds ratio with 95% confidence intervals. Studies were searched across PubMed, Scopus, Web of Science, and Google.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},373294,1790262480,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":19,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":36},549768072016,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","[www.oncotarget.com](www.oncotarget.com) Oncotarget, 2025, Vol. 16, pp: 311-326  \nReview  \nRelationship between ABO blood group antigens and Rh factor with breast cancer: A systematic review and meta-analysis  \nRahaf Alchazal 1,*, Khaled J . Zaitoun2,3,*, Mohammad Al-Qudah3,4, Ghena Zaitoun5, Amira M . Taha6, Othman Saleh4, Mohammad Alqudah 1, Mohammad Abuawwad7, Mohammad Taha7 and Abdullah Yousef Aldalati3  \n1 Faculty of Medicine, Yarmouk University, Irbid, Jordan  \n2 Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA 3 Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan  \n4 Faculty of Medicine, Hashemite University, Amman, Jordan 5 Department of Biology, Edmonds College, Lynnwood, WA 98036, USA 6 Faculty of Medicine, Fayoum University, Egypt  \n7 Faculty of Medicine, Cairo University Kasr Alainy, Egypt  \n*These authors contributed equally to this work  \nCorrespondence to: Khaled J. Zaitoun, [email](email: kzaitou1@jh.edu)[: kzaitou1@jh.edu](email: kzaitou1@jh.edu)[ ](email: kzaitou1@jh.edu)[Keywords](Keywords: breast cancer)[: breast cancer](Keywords: breast cancer); cancer risk factors; blood group antigens; tumor  \nReceived: November 13, 2024 Accepted: April 17, 2025 Published: May 09, 2025  \nCopyright: © 2025 Alchazal et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4 .0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.  \nABSTRACT  \nBackground: Breast cancer is a type of cancer that can affect both males and females, but it is widespread among women. Blood types may be associated with breast cancer, as many studies have reported on this relationship but rarely described it. The primary objective of our research is to summarize and analyze the available evidence to produce comprehensive and accurate information that can be used to make evidence-based decisions.  \nMethods: Researchers searched for studies on breast cancer patients and ABO  \nblood groups across four major databases: PubMed, Scopus, Web of Science, and  \nGoogle. The outcomes of the studies were presented as a relative risk and odds ratio with a 95% confidence interval.  \nResults: Twenty-nine case-control studies with 13029 breast cancer patients.  \nBlood type A was the most common blood type among patients. For blood type A, there was an association with breast cancer (OR = 1.18, 95% CI: 1.03–1.36) . Blood types B, AB, and Rh factor showed no significant association with breast cancer (OR = 0.97, 95% CI: 0.86–1.11, OR = 1.05, 95% CI: 0.89–1.25, and OR = 1.14, 95% CI:  \n0.81–1.60 respectively) in compare to blood type A.  \nConclusions: This study highlights the potential of blood type A as a risk factor for breast cancer compared to blood type O. This relationship was insignificant for blood types B, AB, or Rh. Further studies are needed to understand the mechanisms behind the blood type and breast cancer correlation.  \nINTRODUCTION  \nBreast cancer is the most prevalent form of cancer among females, and the second-leading cause of cancer mortality [1, 2] . Breast cancer mainly occurs in middle-  \naged and older women [3] . The cause of this neoplasm is unclear, but available epidemiological data point to three major contributors that may be important in breast cancer: environmental, genetic, and hormonal factors [4] . Many risk factors are associated with the development of breast  \ncancer; ABO blood groups are rarely considered as a risk factor for breast cancer. However, some studies reported a causal relationship between certain blood groups and increased susceptibility to breast cancer and not a cause of breast cancer [5] .  \nThe relationship between blood type and disease has been studied for many years, uncovering numerous associations between specific blood types and an increased risk of various illnesses. The correlation between t","cbCaisIi6Ddiwrxv","https://ap.wps.com/l/cbCaisIi6Ddiwrxv","pdf",5155165,16,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusions\n# Introduction\n## Breast cancer burden and risk factors\n## ABO blood group system and biological roles\n## Antigen changes in malignant tissues\n## Evidence linking blood type and breast cancer","[{\"question\":\"What was the primary objective of the systematic review?\",\"answer\":\"To summarize and analyze available evidence to produce comprehensive, accurate information that supports evidence-based decisions about the relationship between blood groups and breast cancer.\"},{\"question\":\"Which blood group showed a significant association with breast cancer?\",\"answer\":\"Blood type A showed an association with breast cancer (OR = 1.18, 95% CI: 1.03–1.36) compared with blood type O.\"},{\"question\":\"How were outcomes measured and which databases were searched?\",\"answer\":\"Outcomes were presented as relative risk and odds ratio with 95% confidence intervals. Studies were searched across PubMed, Scopus, Web of Science, and Google.\"}]","Relationship between ABO blood group antigens and Rh factor with breast cancer - A systematic review and meta-analysis | PDF",1790198701]