[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-382935-105":59,"doc-detail-382935-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","regulating-the-regulatory-t-cells-as-cell-therapies-in-autoimmunity-and-cancer","Regulating the regulatory T cells as cell therapies in autoimmunity and cancer","","Regulatory T cells (Tregs) maintain immune homeostasis, but dysregulated Treg activity contributes to autoimmune diseases and cancer. This review examines how Tregs can be reprogrammed to either enhance immune responses for eliminating infected and cancerous cells or dampen harmful immunity to protect self-tissues in autoimmunity. It highlights Treg activation in tumors as a major barrier to effective cancer immunotherapy, while systemic Treg targeting may cause inflammation and autoimmune toxicity. The article emphasizes stability control, receptor- and metabolism-driven highly activated Treg phenotypes, and Treg-based strategies including CAR-Treg and TCR-Treg therapies, along with key challenges and future directions.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/regulating-the-regulatory-t-cells-as-cell-therapies-in-autoimmunity-and-cancer/382935/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/regulating-the-regulatory-t-cells-as-cell-therapies-in-autoimmunity-and-cancer/382935.png","ImageObject",300,407,{"name":92,"@type":93},"Dipper","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-28","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",15,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"Why are regulatory T cells (Tregs) important in autoimmune diseases and cancer?","Question",{"text":113,"@type":114},"Tregs help maintain immune homeostasis. Dysregulated Treg activity is linked to autoimmune disease onset and to immune evasion in cancer by suppressing antitumor T effector responses.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What risks arise from targeting Tregs systemically in cancer?",{"text":118,"@type":114},"Systemic Treg targeting can trigger severe inflammation and autoimmune toxicity, so the review argues for more selective approaches within tumors.",{"name":120,"@type":111,"acceptedAnswer":121},"Which Treg-based therapies are emphasized in the review?",{"text":122,"@type":114},"The review focuses on reprogramming Tregs and discusses Treg-based therapies, especially CAR-Treg therapy and TCR-Treg therapy, as potential tools for cancer immunotherapy.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},382935,1790318487,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":105,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},1374404997633,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","TYPE Review  \nPUBLISHED 27 September 2023 DOI 10.3389/fmed.2023.1244298  \nOPEN ACCESS  \nEDITED BY  \nIan James Martins,  \nUniversity of Western Australia, Australia  \nREVIEWED BY  \nMasanori A. Murayama,  \nKansai Medical University, Japan Luis Alberto Perez Quintero, McGill University, Canada  \n*CORRESPONDENCE  \nHamed Hosseinalizadeh  \n [hamedhosseinalizadeh@gums.ac.ir](hamedhosseinalizadeh@gums.ac.ir)[ ](hamedhosseinalizadeh@gums.ac.ir)Aryan Rezaee  \n [rezaee.aryan@gmail.com](rezaee.aryan@gmail.com)[ ](rezaee.aryan@gmail.com)RECEIVED 22 June 2023 ACCEPTED 01 September 2023 PUBLISHED 27 September 2023  \nCITATION  \nHosseinalizadeh H, Rabiee F, Eghbalifard N, Rajabi H, Klionsky DJ and Rezaee A (2023) Regulating the regulatory T cells as cell therapies in autoimmunity and cancer.  \nFront. Med. 10:1244298 .  \ndoi: 10.3389/fmed.2023.1244298  \nCOPYRIGHT  \n© 2023 Hosseinalizadeh, Rabiee, Eghbalifard, Rajabi, Klionsky and Rezaee. This is an openaccess article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nRegulating the regulatory T cells as cell therapies in autoimmunity and cancer  \nHamed Hosseinalizadeh 1*, Fatemeh Rabiee 2, Negar Eghbalifard3, Hamid Rajabi4, Daniel J. Klionsky 5 and Aryan Rezaee 6*  \n1 Department of Medical Biotechnology, Faculty of Paramedicine, Guilan University of Medical Sciences, Rasht, Iran, 2 Department of Pharmacology and Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran, 3 Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran, 4 Faculty of Medicine, ShahreKord University of Medical Sciences, Shahrekord, Iran, 5 Department of Molecular, Cellular and Developmental Biology, Life Sciences Institute, University of Michigan, Ann Arbor, MI, United States, 6Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran  \nRegulatory T cells (Tregs), possess a pivotal function in the maintenance of immune homeostasis. The dysregulated activity of Tregs has been associated with the onset of autoimmune diseases and cancer. Hence, Tregs are promising targets for interventions aimed at steering the immune response toward the desired path, either by augmenting the immune system to eliminate infected and cancerous cells or by dampening it to curtail the damage to self-tissues in autoimmune disorders. The activation of Tregs has been observed to have a potent immunosuppressive effect against T cells that respond to self-antigens, thus safeguarding our body against autoimmunity. Therefore, promoting Treg cell stability presents a promising strategy for preventing or managing chronic inflammation that results from various autoimmune diseases. On the other hand, Tregs have been found tobe overactivated in several forms of cancer, and their role as immune response regulators with immunosuppressive properties poses a significant impediment to the successful implementation of cancer immunotherapy. However, the targeting of Tregs in a systemic manner may lead to the onset of severe inflammation and autoimmune toxicity. It is imperative to develop more selective methods for targeting the function of Tregs in tumors. In this review, our objective is to elucidate the function of Tregs in tumors and autoimmunity while also delving into numerous therapeutic strategies for reprogramming their function. Our focus is on reprogramming Tregs in a highly activated phenotype driven by the activation of key surface receptors and metabolic reprogramming. Furthermore, we examine Treg-based therapies in autoimmunity, with a specific emphasis on Chimeric Antigen Receptor (CAR)-Treg","cbCaifmQZCGE6Yt0","https://ap.wps.com/l/cbCaifmQZCGE6Yt0","pdf",971551,"English","# Introduction\n## Regulatory T cells in cancer and autoimmunity\n# Therapeutic rationale for reprogramming Tregs\n## Treg stability and chronic inflammation\n## Barriers to cancer immunotherapy\n# Treg-based therapeutic strategies\n## CAR-Treg therapy\n## TCR-Treg therapy\n# Challenges and future steps","[{\"question\":\"Why are regulatory T cells (Tregs) important in autoimmune diseases and cancer?\",\"answer\":\"Tregs help maintain immune homeostasis. Dysregulated Treg activity is linked to autoimmune disease onset and to immune evasion in cancer by suppressing antitumor T effector responses.\"},{\"question\":\"What risks arise from targeting Tregs systemically in cancer?\",\"answer\":\"Systemic Treg targeting can trigger severe inflammation and autoimmune toxicity, so the review argues for more selective approaches within tumors.\"},{\"question\":\"Which Treg-based therapies are emphasized in the review?\",\"answer\":\"The review focuses on reprogramming Tregs and discusses Treg-based therapies, especially CAR-Treg therapy and TCR-Treg therapy, as potential tools for cancer immunotherapy.\"}]","Regulating the regulatory T cells as cell therapies in autoimmunity and cancer | PDF",1790253105,38]