[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-361112-105":59,"doc-detail-361112-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","regulated-cell-death-programs-shaping-cancer-therapy","Regulated cell death programs shaping cancer therapy","","Regulated cell death is foundational to cancer therapy, with apoptosis historically viewed as the dominant driver of treatment benefit. Emerging evidence shows tumors can exploit multiple regulated modalities, including apoptosis, necroptosis, pyroptosis, ferroptosis, cuproptosis, and autophagy-associated death, along with stress-induced programs such as parthanatos and disulfidptosis. These pathways vary in mechanistic definition and translational readiness, and their activation or suppression reshapes tumor progression, immune signaling, and therapy resistance. Therapeutic targeting can improve control, yet death-associated signaling may also enable adaptation and immune evasion, depending on context. ",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/regulated-cell-death-programs-shaping-cancer-therapy/361112/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/regulated-cell-death-programs-shaping-cancer-therapy/361112.png","ImageObject",300,407,{"name":92,"@type":93},"kopisore","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-28","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"Why has apoptosis historically been considered central to cancer therapy efficacy?","Question",{"text":113,"@type":114},"Apoptosis has long been regarded as the principal mechanism underlying treatment efficacy in cancer. The review contrasts this historical view with broader regulated cell death options now recognized in tumors.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Which regulated cell death programs are discussed as important in cancer?",{"text":118,"@type":114},"The review highlights apoptosis, necroptosis, pyroptosis, ferroptosis, cuproptosis, and autophagy-associated death processes. It also mentions emerging stress-induced modalities including parthanatos and disulfidptosis.",{"name":120,"@type":111,"acceptedAnswer":121},"How can targeting regulated death pathways affect tumor outcomes and therapy resistance?",{"text":122,"@type":114},"Activation or suppression of these pathways can influence tumor progression, immune modulation, and therapy resistance. Although inducing specific death modalities can support tumor control, related signaling may also promote tumor adaptation and immune evasion under certain conditions.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},361112,1790184077,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},962090880963,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","Cellular Oncology (2026) 49:102  \n[https://doi.org/10.1007/s13402-026-01232-3](https://doi.org/10.1007/s13402-026-01232-3)  \nREVIEW  \nRegulated cell death programs shaping cancer therapy  \nHaiwen Luo1 · Yingjie Guo2  \nReceived: 17 January 2026 / Accepted: 19 May 2026 © The Author(s) 2026  \nAbstract  \nBackground Regulated cell death has long been central to cancer therapy, with apoptosis historically regarded as the principal mechanism underlying treatment efficacy.  \nMain body Increasing evidence now demonstrates that tumors engage a diverse array of regulated cell death programs, including apoptosis, necroptosis, pyroptosis, ferroptosis, cuproptosis, autophagy-associated death processes, and emerging stress-induced modalities such as parthanatos and disulfidptosis. These pathways can be broadly conceptualized as proteingoverned, metabolism-driven, or stress-induced programs, reflecting distinct mechanistic principles and differing degrees of mechanistic definition and translational maturity. Their activation or suppression can influence tumor progression, immune modulation, and therapy resistance. While therapeutic induction of specific death modalities offers opportunities for tumor control, death-associated signaling may also paradoxically promote tumor adaptation and immune evasion under certain conditions.  \nConclusions This review integrates current understanding of regulated cell death programs to highlight their plasticity in cancer and underscores the importance of mechanism-guided targeting of death pathways to improve cancer therapy outcomes. Clinical trial registration Not applicable.  \nKeywords Regulated cell death · Apoptosis · Ferroptosis · Cellular stress · Therapy resistance  \nAbbreviations  \n7-DHC  \nAA  \nACC  \nACPACSL4  \nAdA ADAR1  \nADCDAKT  \nAMPK  \nASC  \nATG  \n7-dehydrocholesterol Arachidonic acid Acetyl-CoA carboxylase Acyl-carrier protein  \nAcyl-coenzyme A synthetase long-chain family member 4  \nAdrenic acid  \nAdenosine deaminase RNA specific 1 Autophagy-dependent cell death Protein kinase B  \nAMP-activated protein kinase Apoptosis-associated speck-like protein containing a CARD  \nAutophagy-related protein  \n􀀍 Yingjie Guo [yingjie.guo@arcinstitute.org](yingjie.guo@arcinstitute.org)  \n1 Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA  \n2 Arc Institute, 3181 Porter Dr, Palo Alto, CA 94304, USA  \nBAK  \nBAX  \nBH2  \nBH4  \nBIM  \nBIR  \nCAR-T  \nCBD  \nCCL20  \nccRCC  \ncFLIP  \ncGAS-STING  \ncircRNAs  \nCLL  \nCSCCTR1  \nCUL3  \nCYB5R1  \nCYLD  \nDAMPs  \nDBP  \nBCL-2 antagonist/killer BCL-2-associated X protein Dihydrobiopterin Tetrahydrobiopterin BCL-2-like protein 11  \nBaculoviral IAP repeat Chimeric antigen receptor T cell Cannabidiol  \nC-C motif chemokine ligand 20  \nClear-cell renal cell carcinoma  \nCellular FLICE-inhibitory protein Cyclic GMP-AMP synthase-stimulator of interferon genes  \nCircular RNAs  \nChronic lymphocytic leukemia Cancer stem cell  \nCopper transporter-1  \nE3 ubiquitin ligase cullin 3  \nNADH-cytochrome b5 reductase Cylindromatosis  \nDamage-associated molecular patterns Dynamic BH3 profiling  \nDBT  \nDD  \nDED  \nDepMap DHFRDHODH DISC  \nDLAT  \nDLST  \nDMT1  \nDPP9  \nDTCs  \nEMT  \nEPAC  \nES ESCRT  \nFABP7  \nFAO  \nFDA  \nFDX1  \nFSP1  \nGCH1  \nGCSH  \nGLRX5  \nGPX4  \nGSDM  \nGSH  \nHCC  \nHCQHIF-1α IAPs IFN-γ iPLA2 ISCU  \nLA  \nLDH  \nLIASLIPT1  \nLIPT2  \nLOXs LPCAT3  \nLPS Lp-PLA2 LUADMCP-1  \nMHC-I miR  \nMLKL  \nDihydrolipoyl transacylase Death domain  \nDeath effector domain  \nCancer Dependency Map Dihydrofolate reductase Dihydroorotate dehydrogenase Death-inducing signaling complex Dihydrolipoyl transacetylase Dihydrolipoyllysine-residuesuccinyltransferase  \nDivalent metal transporter 1  \nDipeptidyl peptidase 9  \nDisseminated tumor cells  \nEpithelial-mesenchymal transitions Exchange protein directly activated by cAMP  \nElesclomol  \nEndosomal sorting complexes required for transport  \nFatty acid-binding protein 7  \nFatty acid oxidation  \nFood and Drug Administration Ferredoxin 1  \nFerroptos","cbCail5BCTZfAOpo","https://ap.wps.com/l/cbCail5BCTZfAOpo","pdf",3043280,31,"English","# Abstract\n# Main body\n# Conclusions\n# Keywords\n# Abbreviations","[{\"question\":\"Why has apoptosis historically been considered central to cancer therapy efficacy?\",\"answer\":\"Apoptosis has long been regarded as the principal mechanism underlying treatment efficacy in cancer. The review contrasts this historical view with broader regulated cell death options now recognized in tumors.\"},{\"question\":\"Which regulated cell death programs are discussed as important in cancer?\",\"answer\":\"The review highlights apoptosis, necroptosis, pyroptosis, ferroptosis, cuproptosis, and autophagy-associated death processes. It also mentions emerging stress-induced modalities including parthanatos and disulfidptosis.\"},{\"question\":\"How can targeting regulated death pathways affect tumor outcomes and therapy resistance?\",\"answer\":\"Activation or suppression of these pathways can influence tumor progression, immune modulation, and therapy resistance. Although inducing specific death modalities can support tumor control, related signaling may also promote tumor adaptation and immune evasion under certain conditions.\"}]","Regulated cell death programs shaping cancer therapy | PDF",1790143164,78]