[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-331629-105":59,"doc-detail-331629-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","regular-whole-blood-donation-and-gastrointestinal-breast-colorectal-and-haematological-cancer-risk-among-blood-donors-in-australia","Regular whole blood donation and gastrointestinal, breast, colorectal and haematological cancer risk among blood donors in Australia","","Background and Objectives: Several studies suggest lower gastrointestinal and breast cancer risk among blood donors, while others indicate increased haematological cancer risk. This study examined these associations by adjusting for the “healthy donor effect” (HDE). Materials and Methods: Risks for gastrointestinal/colorectal, breast, and haematological cancers were assessed in regular high-frequency whole blood donors using the Sax Institute’s 45 and Up Study linked datasets. Five-year cancer risks, risk differences, and ratios were computed with inverse probability weighting and doubly robust g-methods. Results: Inverse probability weighted results showed no statistically significant differences, with both high and low-frequency groups yielding risk estimates that were not significant. Conclusion: After HDE mitigation, no significant risk differences were found between regular high-frequency and low-frequency whole blood donors for the studied cancer types.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/regular-whole-blood-donation-and-gastrointestinal-breast-colorectal-and-haematological-cancer-risk-among-blood-donors-in-australia/331629/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/regular-whole-blood-donation-and-gastrointestinal-breast-colorectal-and-haematological-cancer-risk-among-blood-donors-in-australia/331629.png","ImageObject",300,407,{"name":92,"@type":93},"Clementine","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What research question does the study address?","Question",{"text":113,"@type":114},"The study evaluates whether regular high-frequency whole blood donation is associated with different 5-year risks of gastrointestinal/colorectal, breast, and haematological cancers compared with low-frequency donation, after accounting for the healthy donor effect.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How does the study mitigate the “healthy donor effect (HDE)”?",{"text":118,"@type":114},"It uses a 5-year qualification period to select exposure groups and applies statistical adjustments including inverse probability weighting and doubly robust g-methods such as TMLE and sequentially doubly robust estimators.",{"name":120,"@type":111,"acceptedAnswer":121},"What were the main findings across the cancer types?",{"text":122,"@type":114},"Risk difference and risk ratio estimates for gastrointestinal/colorectal, breast, and haematological cancers did not show statistically significant differences between high- and low-frequency whole blood donors after HDE mitigation.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},331629,1790122721,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},1374391974564,"https://ap-avatar.wpscdn.com/avatar/14000253aa45c000a9e?x-image-process=image/resize,m_fixed,w_180,h_180&k=1779874745381141002","DOI: 10.1111/vox.13734  \nORIGINA L ARTICLE  \nRegular whole blood donation and gastrointestinal, breast, colorectal and haematological cancer risk among blood donorsin Australia  \nMd Morshadur Rahman 1,2  | Andrew Hayen 1 | John K. Olynyk 3,4 | Anne E. Cust 5,6 | David O. Irving 1,2 | Surendra Karki 2,7   \n1School of Public Health, University of Technology Sydney, Sydney, New South Wales, Australia 2Research and Development, Australian Red Cross Lifeblood, Sydney, New South Wales, Australia 3Curtin Medical School, Curtin University, Bentley, Western Australia, Australia  \n4Fiona Stanley Hospital, Murdoch, Western Australia, Australia  \n5The Daffodil Centre, The University of Sydney, a joint venture with Cancer Council NSW, Sydney, New South Wales, Australia 6Sydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia 7School of Population Health, University of New South Wales, Sydney, New South Wales, Australia  \nCorrespondence  \nSurendra Karki, Australian Red Cross Lifeblood, Sydney, NSW, Australia. Email: [skarki@redcrossblood.org.au](skarki@redcrossblood.org.au)  \nFunding information  \nAustralian governments fund Australian Red Cross Lifeblood to provide blood, blood products and services to the Australian community; University of New South Wales  \nOpen access publishing facilitated by University of New South Wales, as part of the Wiley-University of New South Wales agreement via the Council of Australian University Librarians.  \nAbstract  \nBackground and Objectives: Several studies have suggested that blood donors have lower risk of gastrointestinal and breast cancers, whereas some have indicated an increased risk of haematological cancers. We examined these associations by appropriately adjusting the ‘healthy donor effect’ (HDE) .  \nMaterials and Methods: We examined the risk of gastrointestinal/colorectal, breast and haematological cancers in regular high-frequency whole blood (WB) donors using the Sax Institute’s 45 and Up Study data linked with blood donation and other health-related data. We calculated 5-year cancer risks, risk differences and risk ratios. To mitigate HDE, we used 5-year qualification period to select the exposure groups, and applied statistical adjustments using inverse probability weighting, along with other advanced doubly robust g-methods.  \nResults: We identified 2867 (42 .4%) as regular high-frequency and 3888 (57 . 6%) as low-frequency donors. The inverse probability weighted 5-year risk difference between high and low-frequency donors for gastrointestinal/colorectal cancer was 0.2%(95% CI, 􀀁0 . 1% to 0 . 5%) with a risk ratio of 1 .25 (0 .83–1. 68) . For breast cancer, the risk difference was 􀀁0 .2%(􀀁0 .9% to 0 .4%), with a risk ratio of 0 .87 (0 .48–1.26) . Regarding haematological cancers, the risk difference was 0.0%(􀀁0.3% to 0.5%) with a risk ratio of 0 .97 (0 .55–1.40) . Our doubly robust estimators targeted minimum lossbased estimator (TMLE) and sequentially doubly robust (SDR) estimator, yielded similar results, but none of the findings were statistically significant.  \nThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.  \n© 2024 The Author(s) . Vox Sanguinis published by John Wiley & Sons Ltd on behalf of International Society of Blood Transfusion.  \nBLOOD DONATION AND VARIOUS CANCER RISKS   \n1235  \nConclusion: After applying methods to mitigate the HDE, we did not find any statistically significant differences in the risk of gastrointestinal/colorectal, breast and haematological cancers between regular high-frequency and low-frequency WB donors.  \nKeywords  \nblood donor, cancer, HDE, healthy donor effect, malignancy, whole blood  \nHighlights  \n• We used the ‘qualification period’ method along with advanced statistical met","cbCaimtufYpXSFh3","https://ap.wps.com/l/cbCaimtufYpXSFh3","pdf",737323,11,"English","# Abstract\n## Background and Objectives\n## Materials and Methods\n## Results\n## Conclusion\n# Introduction\n## Iron, whole blood donation, and cancer hypotheses\n## Prior studies and conflicting findings\n## Healthy donor effect (HDE) as a key bias","[{\"question\":\"What research question does the study address?\",\"answer\":\"The study evaluates whether regular high-frequency whole blood donation is associated with different 5-year risks of gastrointestinal/colorectal, breast, and haematological cancers compared with low-frequency donation, after accounting for the healthy donor effect.\"},{\"question\":\"How does the study mitigate the “healthy donor effect (HDE)”?\",\"answer\":\"It uses a 5-year qualification period to select exposure groups and applies statistical adjustments including inverse probability weighting and doubly robust g-methods such as TMLE and sequentially doubly robust estimators.\"},{\"question\":\"What were the main findings across the cancer types?\",\"answer\":\"Risk difference and risk ratio estimates for gastrointestinal/colorectal, breast, and haematological cancers did not show statistically significant differences between high- and low-frequency whole blood donors after HDE mitigation.\"}]","Regular whole blood donation and gastrointestinal, breast, colorectal and haematological cancer risk among blood donors in Australia | PDF",1789994368,28]