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This large prospective UK Biobank cohort study evaluated associations between baseline regular glucosamine use and overall cancer plus 19 site-specific cancers from 2006–2021, using Cox proportional hazards models with subgroup and interaction analyses and multiple sensitivity checks. Results showed higher risks for overall, skin, and prostate cancers, and a lower risk for lung cancer, consistent across sensitivity analyses.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/regular-glucosamine-use-may-have-different-roles-in-the-risk-of-site-specific-cancers-findings-from-a-large-prospective-cohort/376649/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/regular-glucosamine-use-may-have-different-roles-in-the-risk-of-site-specific-cancers-findings-from-a-large-prospective-cohort/376649.png","ImageObject",300,407,{"name":92,"@type":93},"Olivia Brown","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What was the main goal of this study on glucosamine?","Question",{"text":113,"@type":114},"To determine whether the potential anticancer effect of regular glucosamine use differs across different types of site-specific cancers in a large prospective cohort.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How was regular glucosamine use analyzed in relation to cancer risk?",{"text":118,"@type":114},"Participants with complete baseline glucosamine information were followed from 2006 to 2021, and Cox proportional hazards models assessed associations with overall and site-specific cancers, with subgroup, interaction, and sensitivity analyses.",{"name":120,"@type":111,"acceptedAnswer":121},"What cancers showed increased or decreased risk with regular glucosamine use?",{"text":122,"@type":114},"Regular glucosamine use was associated with increased risk of overall cancer, skin cancer, and prostate cancer, while it was associated with reduced risk of lung cancer after adjusting for potential confounders.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},376649,1790456788,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},16904993612988,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","Regular Glucosamine Use May Have Different Roles in the Risk of Site-Specific Cancers: Findings from a Large Prospective Cohort  \nFu-Xiao Li1, Hou-Yu Zhao2, Teng-Fei Lin1, Yi-Wen Jiang1, Di Liu1, Chang Wei1, Zi-Yi Zhao1, Zu-Yao Yang3, Feng Sha1, Zhi-Rong Yang1,4, and Jin-Ling Tang1,5  \n◥  \nBackground: Previous studies indicated that glucosamine supplements may have a general anticancer effect. This study aimed to assess whether the potential effect differs across different types of cancers in a large prospective cohort study.  \nMethods: All participants from the UK Biobank who were free of cancers and had complete information on glucosamine use at baseline were included and followed up from 2006 until 2021 . Cox proportional hazards models were used to assess the associations between regular glucosamine use and different site-specific cancers. Subgroup analyses were performed to explore potential interactions. Several sensitivity analyses were conducted to assess the robustness of the main findings.  \nResults: A total of 450,207 eligible participants (mean age: 56.2 years; females: 53.3%) were included, of whom 84,895 (18.9%) reported regular glucosamine use at baseline. During a median of  \n12.5 years follow-up, glucosamine use was significantly associated with an increased risk of overall cancer [HR, 1.04; 95% confidence interval (CI), 1.01–1.06], skin cancer (HR, 1.11; 95% CI, 1.07–1.15), and prostate cancer (HR, 1.07; 95% CI, 1.01– 1.13), and with a reduced risk of lung cancer (HR, 0.88; 95% CI, 0.79–0.97) after adjusting for potential confounders. Statistical interaction was observed for gender, age, and education for the association of glucosamine use with overall cancer risk (all Pinteraction \u003C 0.027) . These results remained unchanged in the sensitivity analyses.  \nConclusions: Regular glucosamine use was associated with lower risk of lung cancer but higher risk of skin cancer, prostate cancer, and overall cancer.  \nImpact: The roles of glucosamine use potentially differ in the development of different site-specific cancers.  \nIntroduction  \nCancer remains the leading cause of death and poses a huge threat to life expectancy worldwide, with an estimated 19.3 million newly diagnosed cancer cases and almost 10.0 million cancer-related deaths in 2020 (1) . As inflammation plays an important role in carcinogenesis and cancer progression, antiinflammatory drugs are considered a potential intervention for cancer prevention (2–4) .  \nWhile commonly used for treating osteoarthritis and joint pain (3, 5–8), glucosamine has gained popularity, as a kind of nonvitamin and nonmineral dietary supplement with anti-inflammatory properties and low risk ofadverse effects, in the United States and most  \n1Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China. 2Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China. 3Division of Epidemiology, JC School of Public Health and Primary Care, Chinese University of Hong Kong, Hong Kong, China. 4Primary Care Unit, Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK. 5Department of Clinical Data Center, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, China.  \nCorresponding Authors: Zhi-Rong Yang, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China. E-mail: [zr.yang@siat.ac.cn](zr.yang@siat.ac.cn), [zy266@medschl.cam.ac.uk](zy266@medschl.cam.ac.uk); and Feng Sha, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, 1068 Xueyuan  \nAvenue, Shenzhen 518055, China. E-mail: [feng.sha@siat.ac.cn](feng.sha@siat.ac.cn)  \n[Cancer Epidemiol Biomarkers Prev 2023](Cancer Epidemiol Biomarkers Prev 2023);[32:531](32:531)–[41](41)  \n[doi:](doi: 10.1158/1055-9965.EPI-22-1134)[ 10.1158/1055-9965.EPI-22-1134](doi: 10.1158/1055-9965.EPI-22-1134)  \nThis open access article is distri","cbCaipjheV2hPBGo","https://ap.wps.com/l/cbCaipjheV2hPBGo","pdf",2043821,11,"English","# Background\n# Methods\n## Participants and setting\n# Results\n# Conclusions\n# Impact\n# Introduction\n# Materials and Methods","[{\"question\":\"What was the main goal of this study on glucosamine?\",\"answer\":\"To determine whether the potential anticancer effect of regular glucosamine use differs across different types of site-specific cancers in a large prospective cohort.\"},{\"question\":\"How was regular glucosamine use analyzed in relation to cancer risk?\",\"answer\":\"Participants with complete baseline glucosamine information were followed from 2006 to 2021, and Cox proportional hazards models assessed associations with overall and site-specific cancers, with subgroup, interaction, and sensitivity analyses.\"},{\"question\":\"What cancers showed increased or decreased risk with regular glucosamine use?\",\"answer\":\"Regular glucosamine use was associated with increased risk of overall cancer, skin cancer, and prostate cancer, while it was associated with reduced risk of lung cancer after adjusting for potential confounders.\"}]","Regular Glucosamine Use May Have Different Roles in the Risk of Site-Specific Cancers: Findings from a Large Prospective Cohort | PDF",1790220445,28]