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This work investigates how epigenetic mechanisms—including microRNAs (miRNAs) and DNA methylation—contribute to HGSOC progression. High-throughput profiling identified dysregulated miRNAs, with 20 differentially expressed and 11 validated by RT-qPCR. miR-145-3p was consistently downregulated after neoadjuvant therapy and distinguished tumors from controls. DNA methylation regulated MIR145 expression, and restoring miR-145-3p impaired migration and triggered G0/G1 arrest by modulating the cyclin D1-CDK4/6 pathway.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/reduced-levels-of-mir-145-3p-drive-cell-cycle-progression-in-advanced-high-grade-serous-ovarian-cancer/331561/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/reduced-levels-of-mir-145-3p-drive-cell-cycle-progression-in-advanced-high-grade-serous-ovarian-cancer/331561.png","ImageObject",300,407,{"name":92,"@type":93},"Seraphina","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What epigenetic factors does the study focus on in HGSOC?","Question",{"text":112,"@type":113},"The study focuses on microRNAs (miRNAs) and DNA methylation as epigenetic regulators involved in HGSOC progression.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was miR-145-3p identified and verified?",{"text":117,"@type":113},"Comprehensive high-throughput analyses identified dysregulated miRNAs; miR-145-3p was among those validated by RT-qPCR in patient samples and cancer cell lines.",{"name":119,"@type":110,"acceptedAnswer":120},"What functional changes occur when miR-145-3p is overexpressed?",{"text":121,"@type":113},"Overexpression of miR-145-3p reduces cell migration and induces G0/G1 cell cycle arrest by modulating the cyclin D1-CDK4/6 pathway.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331561,1790546292,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":46,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":31,"preview_page_count":14,"preview_urls":144},962075114101,"https://ap-avatar.wpscdn.com/avatar/e000253a75eb197efd?x-image-process=image/resize,m_fixed,w_180,h_180&k=1780044092746381165","Article  \nReduced Levels of miR-145-3p Drive Cell Cycle Progression in Advanced High-Grade Serous Ovarian Cancer  \nEva González-Cantó 1,†, Mariana Monteiro 2,†, Cristina Aghababyan 1,3, Ana Ferrero-Micó 4, Sergio Navarro-Serna 4, Maravillas Mellado-López 4, Sarai Tomás-Pérez 1, Juan Sandoval 5,6,  \nAntoni Llueca 7,8,9, Alejandro Herreros-Pomares 10, Juan Gilabert-Estellés 1,3,11, Vicente Pérez-García 4,12, * and Josep Marí-Alexandre 1,13, *  \nCitation: González-Cantó, E.;  \nMonteiro, M.; Aghababyan, C.; Ferrero-Micó, A.; Navarro-Serna, S.; Mellado-López, M.; Tomás-Pérez, S.; Sandoval, J.; Llueca, A.;  \nHerreros-Pomares, A.; et al. Reduced Levels of miR-145-3p Drive Cell Cycle Progression in Advanced High-Grade Serous Ovarian Cancer. Cells 2024, 13, 1904. [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)cells13221904  \nAcademic Editors: Goberdhan  \nP. Dimri and Yves St.-Pierre  \nReceived: 13 September 2024  \nRevised: 20 October 2024  \nAccepted: 8 November 2024  \nPublished: 18 November 2024  \nCorrection Statement: This article has been republished with a minor change. The change does not affect the scientific content of the article and further details are available within the backmatter of the website version of this article.  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Research Laboratory in Biomarkers in Reproduction, Obstetrics and Gynecology, Research Foundation of the General University Hospital of Valencia, 46014 Valencia, Spain; [evagonzalezcanto@gmail.com](evagonzalezcanto@gmail.com) (E.G.-C.); [dra.kristina.agababyan@gmail.com](dra.kristina.agababyan@gmail.com) (C.A.); [sarai.altea@gmail.com](sarai.altea@gmail.com) (S.T.-P.); juangilaeste@yahoo.es (J.G.-E.)  \n2 Bioinformatics and Genomics Department, Saphetor SA, 1015 Lausanne, Switzerland; [marianabraga.m@gmail.com](marianabraga.m@gmail.com)  \n3 Department of Obstetrics and Gynecology, General University Hospital of Valencia Consortium,  \n46014 Valencia, Spain  \n4 Research Laboratory of Molecular Mechanisms of Placental Invasion, Centro de Investigación Príncipe Felipe, 46012 Valencia, Spain; [aferrero@cipf.es](aferrero@cipf.es) (A.F.-M.); [snavarro@cipf.es](snavarro@cipf.es) (S.N.-S.); [mmellado@cipf.es](mmellado@cipf.es) (M.M.-L.)  \n5 Epigenomics Unit, La Fe Health Research Institute, 46026 Valencia, Spain; epigenomica@iislafe.es  \n6 Biomarkers and Precision Medicine Unit (UByMP), La Fe Health Research Institute, 46026 Valencia, Spain  \n7 Department of Obstetrics and Gynecology, General University Hospital of Castellón,  \n12004 Castellón de la Plana, Spain; [antonillueca@gmail.com](antonillueca@gmail.com)  \n8 Multidisciplinary Unit of Abdominal Pelvic Oncology Surgery (MUAPOS), General University Hospital of Castellón, 12004 Castellón de la Plana, Spain  \n9 Department of Medicine, University Jaume I, 12006 Castellón de la Plana, Spain  \n10 Gynaecological Oncology Laboratory, Department of Oncology, KU Leuven, 3000 Leuven, Belgium; [alejandro.herrerospomares@kuleuven.be](alejandro.herrerospomares@kuleuven.be)  \n11 Department of Pediatrics, Obstetrics and Gynecology, University of Valencia, 46014 Valencia, Spain  \n12 Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas (CSIC), Universidad Autónoma de Madrid (UAM), 28049 Madrid, Spain  \n13 Department of Pathology, General University Hospital of Valencia Consortium, 46014 Valencia, Spain  \n* Correspondence: vperez@cbm.csic.es (V.P.-G.); mari_josale@gva.es (J.M.-A.)† These authors contributed equally to this work.  \nAbstract: High-grade serous ovarian cancer (HGSOC) is the most lethal form of gynecologic cancer, with limited treatment optio","cbCaicTC1bXZbqc2","https://ap.wps.com/l/cbCaicTC1bXZbqc2","pdf",5670745,"English","# Introduction\n## Epigenetic regulation and miRNAs in HGSOC\n# Results\n## Dysregulated miRNAs in advanced-stage patients\n## miR-145-3p downregulation after neoadjuvant therapy\n## DNA methylation control of MIR145 expression\n## Functional effects on migration and cell cycle","[{\"question\":\"What epigenetic factors does the study focus on in HGSOC?\",\"answer\":\"The study focuses on microRNAs (miRNAs) and DNA methylation as epigenetic regulators involved in HGSOC progression.\"},{\"question\":\"How was miR-145-3p identified and verified?\",\"answer\":\"Comprehensive high-throughput analyses identified dysregulated miRNAs; miR-145-3p was among those validated by RT-qPCR in patient samples and cancer cell lines.\"},{\"question\":\"What functional changes occur when miR-145-3p is overexpressed?\",\"answer\":\"Overexpression of miR-145-3p reduces cell migration and induces G0/G1 cell cycle arrest by modulating the cyclin D1-CDK4/6 pathway.\"}]","Reduced Levels of miR-145-3p Drive Cell Cycle Progression in Advanced High-Grade Serous Ovarian Cancer | PDF",1789993996,[145,149],{"page_no":8,"url":146,"width":147,"height":148},"https://res-academy.cache.wpscdn.com/upload/kdocshare/2026-11-08/16af38d7fe1679b5a0934201603d2fd4.webp",983,1390,{"page_no":14,"url":150,"width":151,"height":152},"https://res-academy.cache.wpscdn.com/upload/kdocshare/2026-11-08/bb4382bd3bb605eeb71ab00fa1ac3e3d.webp",982,1388]