[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-423051-105":59,"doc-detail-423051-en":134},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":127,"head_meta":129,"extra_data":131,"updated_unix":133},105,"en","reduced-descending-itch-inhibition-in-peripheral-neuropathy-patients-with-chronic-pruritus","Reduced Descending Itch Inhibition in Peripheral Neuropathy Patients With Chronic Pruritus","","Peripheral neuropathies can present with pruritus and pain, yet neuropathic pruritus mechanisms remain less studied than neuropathic pain. This study examines inhibitory itch mechanisms in 39 participants, including peripheral neuropathy with pruritus, peripheral neuropathy without pruritus, and controls. Dynamic/static quantitative sensory testing, intradermal nerve fiber density, and conditioned pain and itch modulation were used. Electrically induced itch was similar across groups, but chronic itch patients showed reduced itch inhibition, suggesting impaired descending inhibition as a possible mechanism.",{"@graph":69,"@context":126},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/reduced-descending-itch-inhibition-in-peripheral-neuropathy-patients-with-chronic-pruritus/423051/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/reduced-descending-itch-inhibition-in-peripheral-neuropathy-patients-with-chronic-pruritus/423051.png","ImageObject",300,407,{"name":92,"@type":93},"dabgoudw","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-06","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118,122],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main research focus of this study?","Question",{"text":112,"@type":113},"To investigate inhibitory itch mechanisms in patients with peripheral neuropathy (PNP), especially how chronic pruritus relates to reduced itch inhibition.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was itch modulation assessed in the study?",{"text":117,"@type":113},"Participants underwent dynamic and static quantitative sensory testing, intradermal nerve fiber density determination, and conditioned pain (CPM) and itch (CIM) modulation using an electrically induced itch stimulus and a cold-water conditioning stimulus.",{"name":119,"@type":110,"acceptedAnswer":120},"What were the key results regarding itch inhibition?",{"text":121,"@type":113},"Electrically induced itch could be reliably induced in controls and both PNP groups; however, PNP patients with pruritus had significantly shorter itch inhibition (CIM effects) than controls and PNP patients without pruritus.",{"name":123,"@type":110,"acceptedAnswer":124},"What mechanism do the authors propose based on the findings?",{"text":125,"@type":113},"Reduced endogenous itch inhibition, potentially reflecting impaired descending itch inhibition, may facilitate chronic itch in peripheral neuropathy.","https://schema.org",{"og:url":83,"og:type":128,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":130,"canonical":83},"index,follow",{"doc_id":132,"site_id":62},423051,1790879466,{"code":4,"msg":5,"data":135},{"doc_id":132,"user_id":136,"nickname":92,"user_avatar":137,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":138,"file_id":139,"file_url":140,"file_type":141,"file_size":142,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":143,"language":144,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":145,"faqs":146,"seo_title":147,"seo_description":67,"update_tm":148,"read_time":149,"preview_page_count":4},3985747860484,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","European Journal of Pain  \nORIGINAL ARTICLE  OPEN ACCESS   \nReduced Descending Itch Inhibition in Peripheral Neuropathy Patients With Chronic Pruritus  \nJonas Eck1,2 | Stephan Bigalke1,3 | Martin Schmelz4 | Daniela Constanze Rosenberger1 | Bruno Pradier1 | Frank Rutsch5 | Claudia Sommer6 | Frank Birklein7 | Daniel Segelcke1  | Esther Pogatzki-Zahn1   \n1Department of Anaesthesiology Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany | 2Department of Orthopedics and Trauma Surgery, Freiburg University Hospital, Freiburg, Germany | 3Department of Anaesthesiology Intensive Care and Pain Medicine, BG University Hospital Bochum, Bochum, Germany | 4Department of Experimental Pain Research, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany | 5Department of General Pediatrics, Muenster University Children's Hospital, Münster, Germany | 6Department of Neurology, University Hospital Würzburg, Würzburg, Germany | 7Department of Neurology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany  \nCorrespondence: Esther Pogatzki-Zahn ([pogatzki@anit.ukmuenster.de](pogatzki@anit.ukmuenster.de))  \nReceived: 15 July 2025 | Revised: 17 November 2025 | Accepted: 4 December 2025  \nABSTRACT  \nBackground: Peripheral neuropathies (PNP) cause a wide range of symptoms of which pruritus and pain are a major burden to patients. Clarifying their mechanisms will facilitate the adequate symptom management. In contrast to neuropathic pain, neuropathic pruritus has long been understudied. We investigate inhibitory pruritus mechanisms in patients with PNP.  \nMethods: A total of 39 participants (median age: 57 years [27–81], 25♀/14♂), including 16 patients with PNP and pruritus (PNPPRU) and 8 with PNP but without pruritus (PNPNO-PRU), and 15 controls, were enrolled and phenotyped using dynamic and static quantitative sensory testing, determination of intradermal nerve fibre density, and conditioned pain (CPM) and itch (CIM) modulation. For CIM, an electrically induced itch test stimulus (TS) was applied with an individual itch intensity of > 30 NRS (0–100) . A cold-water bath (contralateral side) served as the conditioning stimulus (CS) . Itch, pain intensity and the desire to scratch upon TS were rated before, during and after the CS was applied.  \nResults: Using our novel CIM protocol, well-controlled and stable itch was electrically induced in controls and in both PNP groups, regardless of whether or not pruritus was a symptom. Concomitant painful cold stimuli reduced electrically induced itchin all three groups to a similar degree. However, PNPPRU patients had significantly shorter itch inhibition (CIM effects) compared to controls and PNPNO-PRU, whereas CPM effects were not different between groups.  \nConclusions: The results show reduced endogenous itch inhibition in patients with chronic itch, which represents a possible mechanism of chronic pruritus in PNP.  \nSignificance Statement: Reduced itch inhibition is associated with the symptom of chronic pruritus in PNP patients, suggesting that reduced descending itch inhibition may facilitate chronic itch in peripheral neuropathy.  \n1 | Introduction  \nPeripheral neuropathies (PNP) may have very different causes. Chronic neuropathic pain, neuropathic pruritus and various other sensory symptoms are commonly observed in PNP  \npatients, causing significant personal and economic burden (Baka et al. 2024) . Although pain has been extensively studied in PNP patients, chronic neuropathic pruritus (nPru) as a form of chronic itch remains poorly understood (Steinhoffet al. 2019) . Despite a significant impairment of quality of life, there are no  \n\n| Jonas Eck and Stephan Bigalke contributed equally to this work. |\n| --- |\n| This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.\u003Cbr>© 2026 The Aut","cbCaivJDjYeag38r","https://ap.wps.com/l/cbCaivJDjYeag38r","pdf",3801552,11,"English","# Introduction\n# Methods\n# Results\n# Conclusions","[{\"question\":\"What is the main research focus of this study?\",\"answer\":\"To investigate inhibitory itch mechanisms in patients with peripheral neuropathy (PNP), especially how chronic pruritus relates to reduced itch inhibition.\"},{\"question\":\"How was itch modulation assessed in the study?\",\"answer\":\"Participants underwent dynamic and static quantitative sensory testing, intradermal nerve fiber density determination, and conditioned pain (CPM) and itch (CIM) modulation using an electrically induced itch stimulus and a cold-water conditioning stimulus.\"},{\"question\":\"What were the key results regarding itch inhibition?\",\"answer\":\"Electrically induced itch could be reliably induced in controls and both PNP groups; however, PNP patients with pruritus had significantly shorter itch inhibition (CIM effects) than controls and PNP patients without pruritus.\"},{\"question\":\"What mechanism do the authors propose based on the findings?\",\"answer\":\"Reduced endogenous itch inhibition, potentially reflecting impaired descending itch inhibition, may facilitate chronic itch in peripheral neuropathy.\"}]","Reduced Descending Itch Inhibition in Peripheral Neuropathy Patients With Chronic Pruritus | PDF",1790629954,28]