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Red light rapidly increased dermal thickness and enhanced epidermal renewal by promoting collagen synthesis in dermal fibroblasts, while AKT signaling reduced collagen degradation.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/red-light-promotes-dermis-epidermis-remodeling-via-tgf-and-akt-mediated-collagen-dynamics-in-naturally-aging-mice/456347/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/red-light-promotes-dermis-epidermis-remodeling-via-tgf-and-akt-mediated-collagen-dynamics-in-naturally-aging-mice/456347.png","ImageObject",300,407,{"name":42,"@type":43},"Anna Hans","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-30","2026-09-30",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",6,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is the main goal of the study on red light therapy?","Question",{"text":63,"@type":64},"To clarify how red light promotes coordinated dermis-epidermis remodeling and reverses collagen-related skin degeneration in naturally aging mice.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Which skin cell activities are enhanced by red light?",{"text":68,"@type":64},"Red light stimulates dermal fibroblast collagen synthesis and supports epidermal keratinocyte proliferation and differentiation through collagen/integrin-related signaling.",{"name":70,"@type":61,"acceptedAnswer":71},"How do TGFβ and AKT signaling contribute to collagen remodeling?",{"text":72,"@type":64},"Red light increases endogenous TGFβ to activate SMAD2/3/4 signaling and up-regulate type I collagen, while AKT activation suppresses collagen degradation via an NRF2/HO-1-dependent pathway.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},456347,1791314442,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,105,109,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},"Technology",50,"technology",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":107,"slug":108},7,40,"healthcare",{"id":110,"doc_module":4,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},8,"Research & Report",30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":106,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":107,"preview_page_count":4},5909892332657,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","Chang et al. Zool. Res. 2025, 46(5): 967−982  \n[https://doi.org/10.24272/j.issn.2095-8137.2024.405](https://doi.org/10.24272/j.issn.2095-8137.2024.405)  \n[https://cstr.cn/32248.14.zr.2024.405](https://cstr.cn/32248.14.zr.2024.405)  \nArticle Open Access  \nRed light promotes dermis-epidermis remodeling via TGFβ and AKT-mediated collagen dynamics in naturally aging mice  \nHaocai Chang1,2,\\#,* , Qi Shen1,2,\\# , Yongci Tan1,2 , Jing Tong1,2 , Zhan Zhang3,4 , Wenwen Ouyang1,2 , Xiaorui An1,2 , Sihua Yang1,2,*  \n1 MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, School of Optoelectronic Science and Engineering, South China Normal University, Guangzhou, Guangdong 510631, China  \n2 Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, School of Optoelectronic Science and Engineering, South China Normal University, Guangzhou, Guangdong 510631, China  \n3 Brain Research Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510120, China  \n4 Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510120, China  \nABSTRACT  \nRed light therapy is a clinically validated, noninvasive approach for improving skin structure and stimulating collagen renewal. However, the molecular mechanisms by which light therapy reverses collagen-related skin degeneration remain unclear. Using a natural aging mouse model, this study investigated the effects of red light therapy on skin structure and regeneration. Unlike other wavelengths, red light rapidly increased dermal thickness and stimulated epidermal renewal by enhancing collagen synthesis in dermal fibroblasts and activating collagen/integrin-induced proliferation and differentiation of epidermal keratinocytes, resulting in significant improvements in skin morphology. Mechanistically, red light increased endogenous TGFβ expression in fibroblasts, which up-regulated type I collagen mRNA and protein expression via activation of SMAD2/3/4 nuclear translocation. Simultaneously, red light elevated intracellular cAMP, triggering AKT activation that inhibited matrix metalloproteinase expression via the NRF2/HO-1-dependent pathway, thereby reducing collagen degradation. The accumulation of type I collagen in dermal fibroblasts stimulated integrin signaling, promoting epidermal keratinocyte proliferation and differentiation. Red light-induced AKT activation also enhanced fibroblast proliferation, further amplifying collagen production and collagen-mediated epidermal renewal. These findings elucidate the mechanisms by which red light stimulates endogenous TGFβ and AKT signaling to regulate type I collagen production, driving coordinated dermis-epidermis  \nThis is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ([http://](http://)[ ](http://)[creativecommons.org/l](creativecommons.org/l)icenses/by-nc/4 .0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.  \nCopyright ©2025 Editorial Office of Zoological Research, Kunming Institute of Zoology, Chinese Academy of Sciences  \nremodeling. This pathway represents a potential therapeutic target for the prevention and treatment of agerelated dermal degeneration.  \nKeywords: Red light; Dermal fibroblasts; Epidermal keratinocytes; Type I collagen; Skin degeneration  \nINTRODUCTION  \nThe growing demand for safe and noninvasive therapies to counteract age-related skin degeneration has spurred intensive research into light-based interventions, particularly red light therapy, which has demonstrated clinical efficacy in promoting collagen synthesis and improving skin texture (Garza et al. , 2023; Lee et al. , 2015) . However, despite its therapeutic potential, the molecular mechanisms underlying these effects remain poorly understood, limiting its translational refinement and b","cbCaigDu6JApIjWV","https://ap.wps.com/l/cbCaigDu6JApIjWV","pdf",26010136,16,"English","# Abstract\n# Introduction\n## Background on red light therapy\n## Features and causes of age-related skin degeneration\n## Role of TGFβ, AKT, and collagen remodeling","[{\"question\":\"What is the main goal of the study on red light therapy?\",\"answer\":\"To clarify how red light promotes coordinated dermis-epidermis remodeling and reverses collagen-related skin degeneration in naturally aging mice.\"},{\"question\":\"Which skin cell activities are enhanced by red light?\",\"answer\":\"Red light stimulates dermal fibroblast collagen synthesis and supports epidermal keratinocyte proliferation and differentiation through collagen/integrin-related signaling.\"},{\"question\":\"How do TGFβ and AKT signaling contribute to collagen remodeling?\",\"answer\":\"Red light increases endogenous TGFβ to activate SMAD2/3/4 signaling and up-regulate type I collagen, while AKT activation suppresses collagen degradation via an NRF2/HO-1-dependent pathway.\"}]","Red light promotes dermis-epidermis remodeling via TGFβ and AKT-mediated collagen dynamics in naturally aging mice | PDF",1790745687]