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Surgery with free margins is described as the primary treatment, often combined with neck dissection, adjuvant radiotherapy, chemotherapy, and immunotherapy. The report presents a 33-year-old woman with recurrent malignant melanoma treated by resection and adjuvant radiotherapy, followed by maintenance follow-up without recurrence.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/recurrent-malignant-melanoma-on-the-tongue-a-case-report-and-review-of-the-literature/373285/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/recurrent-malignant-melanoma-on-the-tongue-a-case-report-and-review-of-the-literature/373285.png","ImageObject",300,407,{"name":92,"@type":93},"Kyle","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is tongue malignant melanoma difficult to manage?","Question",{"text":112,"@type":113},"Tongue malignant melanoma is rare and often presents at a late stage, so evidence-based optimal treatment strategies remain elusive.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was recurrence confirmed and treated in the case?",{"text":117,"@type":113},"A new tongue lesion discovered during follow-up was confirmed as malignant melanoma and resected with clear surgical margins, followed by reconstruction and adjuvant radiotherapy.",{"name":119,"@type":110,"acceptedAnswer":120},"What is the recommended diagnostic approach for suspicious tongue or oral mucosa lesions?",{"text":121,"@type":113},"Perform thorough clinical evaluation and proceed with histopathological and immunohistochemical examination of suspicious lesions to enable early diagnosis.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},373285,1790240613,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":34,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},3985741905716,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","Cancer Reports  \nCASE REPORT  OPEN ACCESS   \nRecurrent Malignant Melanoma on the Tongue: A Case Report and Review of the Literature  \nMaziar Motiee-Langroudi1 | Athena Farahzadi2  | Pouyan Aminshakib3  \n1Imam Khomeini Complex Hospital, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran | 2Division of Surgical Oncology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran | 3Pathology Department, Cancer Institute, Imam Khomeini Complex Hospital, Tehran University of Medical Sciences, Tehran, Iran  \nCorrespondence: Athena Farahzadi ([athenafarahzadi@gmail.com](athenafarahzadi@gmail.com))  \nReceived: 15 July 2024 | Revised: 9 March 2025 | Accepted: 15 April 2025  \nFunding: The authors received no specific funding for this work.  \nKeywords: mucosal melanoma | recurrent tongue melanoma | tongue malignant melanoma  \nABSTRACT  \nBackground: Melanoma of the oral mucosa is an uncommon cancer arising from the tissues lining the mouth. Among oronasal malignant melanomas, tongue melanoma makes up a mere 2% . Optimal treatments for this rare and often late-stage disease remain elusive. However, surgery with free margins is considered the primary treatment and is often combined with other therapies such as neck dissection, adjuvant radiotherapy, chemotherapy, and immunotherapy.  \nCase: This case involves a 33-year-old woman with a history of malignant melanoma on her tongue. She had previously undergone a partial glossectomy and was on maintenance imatinib treatment for ~2 years. During her follow-up, a new lesion was discovered on her tongue, which was confirmed to be malignant melanoma and was resected. The tumor exhibited a depth of invasion of 8 mm. All surgical margins were clear, with the closest margin being 3 mm. The lesion was reconstructed with asubmental flap. Adjuvant radiotherapy was also given. The patient has been on maintenance follow-up for 3 years with no signs of recurrence.  \nConclusion: Malignant melanoma should be considered in the differential diagnosis of pigmented and non-pigmented lesions of the tongue and oral mucosa. A thorough clinical evaluation, followed by histopathological and immunohistochemical examination of any suspicious lesions, is essential for early diagnosis. Early detection and prompt treatment are crucial for optimizing patient outcomes and improving survival rates.  \n1 | Introduction  \nPrimary oral mucosal melanoma (OMM) is a very uncommon entity that makes up about 1%–8% of all malignant melanomasand \u003C 0.5% of all oral malignant tumors [1, 2] . It originates from melanocytes in the oral cavity, which are part of the immune system in the mouth [1, 3] .  \nPrimary oral mucosal melanoma (OMM) most frequently involves the maxillary gingiva or hard palate, with tongue  \ninvolvement occurring in under 2% of oronasal melanoma cases [4]. The etiology of OMM is unknown. According to the literature, environmental factors and habits like alcohol consumption, cigarette smoking, denture irritation, and trauma may affect its occurrence [5, 6] . Additionally, individuals with weakened immune systems, including those with conditions like HIV, nonHodgkin lymphoma, chronic lymphocytic leukemia, or organ transplants, are more susceptible to developing OMM [5] . While research is ongoing, a family history of melanoma, particularly familial melanoma, may increase the risk of developing OMM.  \nThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \n© 2025 The Author(s). Cancer Reports published by Wiley Periodicals LLC.  \nCancer Reports, 2025; 8:e70215 1 of 7  \n[https://doi.org/10.1002/cnr2.70215](https://doi.org/10.1002/cnr2.70215)  \nThe majority of OMMs are believed to be De nova [7] . Mucosal melanosis was found to be related to oral malignant melanoma in 66% of cases. It was present before diagnosis in 36.2% of cases and was synchrono","cbCaigybmRXTweLs","https://ap.wps.com/l/cbCaigybmRXTweLs","pdf",752133,"English","# Introduction\n## Case Report\n## Conclusion","[{\"question\":\"Why is tongue malignant melanoma difficult to manage?\",\"answer\":\"Tongue malignant melanoma is rare and often presents at a late stage, so evidence-based optimal treatment strategies remain elusive.\"},{\"question\":\"How was recurrence confirmed and treated in the case?\",\"answer\":\"A new tongue lesion discovered during follow-up was confirmed as malignant melanoma and resected with clear surgical margins, followed by reconstruction and adjuvant radiotherapy.\"},{\"question\":\"What is the recommended diagnostic approach for suspicious tongue or oral mucosa lesions?\",\"answer\":\"Perform thorough clinical evaluation and proceed with histopathological and immunohistochemical examination of suspicious lesions to enable early diagnosis.\"}]","Recurrent Malignant Melanoma on the Tongue - A Case Report and Review of the Literature | PDF",1790198568,18]