[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-442828-105":59,"doc-detail-442828-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","rectal-paraganglioma-presenting-as-a-diminutive-polyp","Rectal Paraganglioma Presenting as a Diminutive Polyp","","A 46-year-old man underwent colonoscopy for nonbloody diarrhea lasting about 1 year. Endoscopy showed a diminutive 4 mm rectal polyp that was removed with cold snare. Histology demonstrated paraganglioma with chromogranin and synaptophysin immunoreactivity, and staging with total-body computed tomography and abdominal magnetic resonance imaging showed no metastasis. A repeat colonoscopy after 9 months was normal, and the patient remained under departmental follow-up.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/rectal-paraganglioma-presenting-as-a-diminutive-polyp/442828/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/rectal-paraganglioma-presenting-as-a-diminutive-polyp/442828.png","ImageObject",300,407,{"name":92,"@type":93},"dhado","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What prompted the colonoscopy in this case report?","Question",{"text":112,"@type":113},"The patient presented with nonbloody diarrhea lasting about 1 year, prompting colonoscopy evaluation.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was the rectal lesion treated and what did pathology show?",{"text":117,"@type":113},"A diminutive 4 mm rectal polyp was removed with cold snare. Pathology confirmed paraganglioma, positive for chromogranin and synaptophysin.",{"name":119,"@type":110,"acceptedAnswer":120},"What staging and follow-up results were reported?",{"text":121,"@type":113},"Total-body computed tomography and abdominal MRI showed no metastasis. A repeat colonoscopy after 9 months was normal, and the patient continued follow-up.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},442828,1791028702,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":14,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":24,"preview_page_count":4},5909893218464,"https://ap-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","ACG CASE REPORTS JOURNAL  \nIMAGE | ENDOSCOPY  \nRectal Paraganglioma Presenting as a Diminutive Polyp  \nFilip Martinovic, MD 1 , Monica Arena, MD 1 , Giuseppe Iabichino, MD 1 , Milena Di Leo, MD 1 , Moreno Zagni, MD2 , and Luca De Luca, MD 1  \n1 Gastroenterology and Digestive Endoscopy, ASSTSanti Paolo e Carlo, Milan, Italy 2Department of Pathology, ASSTSanti Paolo e Carlo, Milan, Italy  \nCASE REPORT  \nA 46-year-old man presented to our clinic for a colonoscopy due to nonbloody diarrhea lasting about 1 year. His medical history revealed only arterial hypertension treated with angiotensin-converting enzyme inhibitor therapy.  \nFigure 1. Colonoscopy images showing polyp under white light (A) and narrow-band imaging (B) .  \nFigure 2. Histological features of the lesion showing immunoreactivity chromogranin (A) and synaptophysin (B) .  \nACG Case Rep J 2026;13:e01922 . doi:10 . 14309/crj.0000000000001922. Published online: January 5, 2026 Correspondence: Luca De Luca, MD ([luca.deluca@asst-santipaolocarlo.it](luca.deluca@asst-santipaolocarlo.it)) .  \nACG Case Reports [Journal / Volume 13 acgcasereports.com 1](Journal / Volume 13 acgcasereports.com 1)  \nMartinovic et al Rectal Paraganglioma  \nThe examination showed normal ileal and colonic mucosa. In the rectum, a diminutive polyp of4mm was found and removed with cold snare. Images of the polyp under white light and narrow-band imaging are provided (Figure1). The pathological findings revealed the presence ofparaganglioma. The polyp was positive for chromogranin and synaptophysin (Figure 2) .  \nA total-body computed tomography scan and magnetic resonance imaging of the abdomen were performed, revealing no sign of metastasis. A colonoscopy was repeated after 9 months, resulting normal.  \nThe patient is still under follow-up at our department.  \nParagangliomas are rare nonepithelial neuroendocrine tumors that typically develop in the extra-adrenal sites along the sympathetic and/or the parasympathetic chain.  \nTheir location in the gastrointestinal tract is quite rare. In literature, there are only few cases regarding the colon and rectum and only of large and metastatic lesions.1–5  \nTo thebest ofour knowledge, we present the first case of a rectal paraganglioma reported as a diminutive polyp.  \nDISCLOSURES  \nAuthor contributions: L. De Luca, F. Martinovic, M. Arena, DL Milena, and I. Giuseppe wrote this article, and L. De Luca  \ncritically reviewed it. Z. Moreno provided the histological images of the polyp. All the authors approve this draft. L. De Luca is the article guarantor.  \nFinancial disclosure: None to report.  \nInformed consent was obtained for this case report. Received July 15, 2025; Accepted November 4, 2025  \nREFERENCES  \n1. Yu L, Wang J. Malignant paraganglioma of the rectum: The first case report and a review of the literature. World J Gastroenterol. 2013;19(44): 8151–5.  \n2. Araki T, Takeshita S, Kawasaki H, et al. Rectal paraganglioma. Intern Med. 2019;58(2):195–9.  \n3. Zhu X, Huang Z, Dong L, Zhao H, Lu H. A case report of primary colonic paraganglioma with lymph node metastasis. Front Surg. 2022;9: 961514.  \n4. Shamah S, Rahmani R, Tsirlin Y, Li J, Iswara K. A rare case of paraganglioma presenting as severe rectal bleeding: 841. Am J Gastroenterol. 2011;106:S313.  \n5. Tampakis A, Schlageter M, Oertli D, Misteli H. Letter to the editor: A case of an extraadrenal paraganglioma in the sigma in a patient with recurrent sigmadiverticulitis. Int J Colorectal Dis. 2016;31(3): 729–31.  \nCopyright: ª 2026 The Author(s) . Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology. This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.  \nACG Case Reports [Journal / Vol","cbCaivrOnpcfJkVO","https://ap.wps.com/l/cbCaivrOnpcfJkVO","pdf",315582,"English","# Case report\n## Endoscopic findings and pathology\n## Staging, follow-up, and discussion","[{\"question\":\"What prompted the colonoscopy in this case report?\",\"answer\":\"The patient presented with nonbloody diarrhea lasting about 1 year, prompting colonoscopy evaluation.\"},{\"question\":\"How was the rectal lesion treated and what did pathology show?\",\"answer\":\"A diminutive 4 mm rectal polyp was removed with cold snare. Pathology confirmed paraganglioma, positive for chromogranin and synaptophysin.\"},{\"question\":\"What staging and follow-up results were reported?\",\"answer\":\"Total-body computed tomography and abdominal MRI showed no metastasis. A repeat colonoscopy after 9 months was normal, and the patient continued follow-up.\"}]","Rectal Paraganglioma Presenting as a Diminutive Polyp | PDF",1790701822]