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This study examined whether a trusted messenger improves recruitment into a randomized trial evaluating a mobile caregiver intervention for dementia, targeting caregiver burden and patient behavioral and psychological symptoms (BPSD). From 4630 contacted potential participants, recruitment used either cold calls from a health registry or calls initiated through a memory care physician referral via a trusted messenger. Call-to-consent ratios were compared using a two-proportion Z test.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/recruitment-of-informal-caregivers-of-persons-with-dementia-into-clinical-trial-the-power-of-the-messenger/427773/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/recruitment-of-informal-caregivers-of-persons-with-dementia-into-clinical-trial-the-power-of-the-messenger/427773.png","ImageObject",300,407,{"name":92,"@type":93},"Maya Linwood","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-20","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the study’s main objective?","Question",{"text":112,"@type":113},"To assess the effect of a trusted messenger on recruitment into a randomized controlled trial for a mobile caregiver intervention in dementia.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were participants recruited in this study?",{"text":117,"@type":113},"Recruitment occurred through two approaches: cold calls from a health system registry and trusted messenger calls from patients referred by a memory care physician.",{"name":119,"@type":110,"acceptedAnswer":120},"What outcome measure was used to evaluate recruitment?",{"text":121,"@type":113},"The call-to-consent ratio was used as the primary outcome measure.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},427773,1790796644,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":81},962084928432,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Innovation in Aging, 2025, Vol. 9, No. S2 653  \nAbstract citation ID: igaf122.2230  \nRECRUITMENT OF INFORMAL CAREGIVERS OF  \nPERSONS WITH DEMENTIA INTO CLINICAL TRIAL:  \nTHE POWER OF THE MESSENGER.  \nZayn Boustani1, Mariana Stavig2, Hanani Ndebele2,  \nJordan Hill2, Miriam Jocelyn Rodriguez2, Lilian Golzarri-Arroyo2, Richard Holden2, and Malaz Boustani3, 1. Indiana University Bloomington, Chicago, Illinois, United States, 2. Indiana University Bloomington, Bloomington, Indiana, United States, 3. Indiana University, Indianapolis, Indiana, United States  \nIntro: The success of a randomized controlled trial depends on the timely and effective recruitment of participants. We aimed to investigate the effect of a trusted messenger on the recruitment process into a randomized controlled trial testing the efficacy of a mobile caregiver intervention in reducing caregiver burden and patient behavioral and psychological symptoms of dementia (BPSD). Methods: A total of n = 4630 potential participants were contacted. Recruitment occurred via (1)“Cold Call,” where patients from a health system registry were called by research staff, and (2)“trusted messenger,” where research staff called patients who were referred directly from a memory care physician. The outcome measure was the call-to-consent ratio. A two-population proportion Z-test compared the ratios between the two recruitment methods. Results: The enrollment rate was 23.88% for participants recruited via the “trusted messenger”  \nmethod and 1. 18% for those recruited from the “cold calls”method (z = 15.11, p ≈ 0.0000) . Conclusions: “Trusted Messenger” was 20 times more effective than “Cold Calls” in recruiting human subjects into a clinical trial. Trusted Messenger leverage preexisting relationship. Although “Cold calls” is perceived as easy for the researcher to complete, it yields fewer enrollments per points of contact. Future studies should examine and compare other recruitment methods among ethnically diverse samples such as community outreach, flyer posting, and door-to-door solicitation.","cbCaifzmahwRryFZ","https://ap.wps.com/l/cbCaifzmahwRryFZ","pdf",47825,"English","# Introduction\n# Methods\n# Results\n# Conclusions\n# Future directions","[{\"question\":\"What was the study’s main objective?\",\"answer\":\"To assess the effect of a trusted messenger on recruitment into a randomized controlled trial for a mobile caregiver intervention in dementia.\"},{\"question\":\"How were participants recruited in this study?\",\"answer\":\"Recruitment occurred through two approaches: cold calls from a health system registry and trusted messenger calls from patients referred by a memory care physician.\"},{\"question\":\"What outcome measure was used to evaluate recruitment?\",\"answer\":\"The call-to-consent ratio was used as the primary outcome measure.\"}]","Recruitment of Informal Caregivers of Persons with Dementia into Clinical Trial - The Power of the Messenger | PDF",1790644783]