[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-455151-105":59,"doc-detail-455151-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","recovery-of-physical-function-during-hospitalization-among-heart-failure-patients-with-and-without-cachexia","Recovery of Physical Function during Hospitalization among Heart Failure Patients with and without Cachexia","","Study objectives focused on determining how cachexia influences recovery of physical function during hospitalization in heart failure patients, using the newer Asian Working Group for Cachexia criteria, and on describing clinical characteristics associated with cachexia. Cachexia at discharge was operationalized as low body mass index plus low handgrip strength, elevated C-reactive protein, or anorexia. Physical function was measured at admission and discharge with two-way ANOVA and hierarchical logistic regression.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/recovery-of-physical-function-during-hospitalization-among-heart-failure-patients-with-and-without-cachexia/455151/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/recovery-of-physical-function-during-hospitalization-among-heart-failure-patients-with-and-without-cachexia/455151.png","ImageObject",300,407,{"name":92,"@type":93},"Danger Angel","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-03","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"How was cachexia defined at discharge in this study?","Question",{"text":113,"@type":114},"Cachexia at discharge was defined using low body mass index combined with one or more of: low handgrip strength, elevated C-reactive protein, or anorexia.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What happened to physical function during hospitalization in patients with cachexia?",{"text":118,"@type":114},"Heart failure patients with cachexia showed no improvement in physical function from admission to discharge, unlike those without cachexia.",{"name":120,"@type":111,"acceptedAnswer":121},"Which factors were associated with the presence of cachexia?",{"text":122,"@type":114},"Hierarchical logistic regression identified low GNRI and low muscle power as factors associated with cachexia in heart failure patients.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},455151,1791077459,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},962090769052,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","P H Y S I C A LT H E R A P YR E S E A R C H  \nORIGINAL ARTICLE  \nRecovery of Physical Function during Hospitalization among Heart Failure Patients with and without Cachexia  \nTakuya UMEHARA, PT, PhD1, Akinori KANEGUCHI, PT, PhD1, Yuji NAKASHIMA, PT2, Yosuke YAMAMOTO, PT2, Nobuhisa KATAYAMA, PT2, and Nobuhiro KITO, PT, PhD1  \n1)Department of Rehabilitation, Faculty of Rehabilitation, Hiroshima International University, Japan  \n2)Department of Rehabilitation, Kure Kyosai Hospital, Japan  \nABSTRACT. Objectives: This study aimed to clarify the impact of cachexia on physical function recovery during hospitalization among patients with heart failure using the new Asian Working Group for Cachexia criteria and to identify the characteristics of heart failure patients with cachexia.  \nMethods: Cachexia at discharge was defined by low body mass index combined with one or more of the following: low handgrip strength, elevated C-reactive protein, or anorexia. Physical function was assessed at admission and discharge. Two-way analysis of variance (ANOVA) was performed to examine the interaction and main effects of the presence of cachexia and duration factors (admission and discharge) on physical function. Hierarchical logistic regression analysis was performed to explore factors associated with the presence of cachexia.  \nResults: Of the 96 patients analyzed, 26 were heart failure patients with cachexia, and 70 were heart failure patients without cachexia. The results of the 2-way ANOVA indicated that heart failure patients without cachexia exhibited improved physical function at discharge compared to that at admission. In contrast, heart failure patients with cachexia showed no improvement in physical function during hospitalization. Hierarchical logistic regression analysis revealed that a low geriatric nutritional risk index (GNRI) and low muscle power were associated with the presence of cachexia in patients with heart failure.  \nConclusions: Our results suggest that heart failure patients with cachexia experience poor recovery of physical function during hospitalization, and that reduced muscle power and deterioration in nutritional status, as indicated by a low GNRI, were associated with the presence of cachexia.  \nKey words: Heart failure, Cachexia, Recovery of function  \n(Phys Ther Res 28: 188–197, 2025)  \nReceived: July 22, 2025  \nAccepted: October 8, 2025  \nAdvance Publication by J-STAGE: November 14, 2025  \nCorrespondence to: Takuya Umehara. Department of Rehabilitation, Faculty of Rehabilitation, Hiroshima International University, 555-36 Kurose-Gakuendai, Higashi-Hiroshima, Hiroshima 739-2695, Japan  \ne-mail: [t-umeha@hirokoku-u.ac.jp](t-umeha@hirokoku-u.ac.jp)  \n[doi: 10.1298/ptr.25-E10364](doi: 10.1298/ptr.25-E10364)  \nThis work is licensed under a Creative Commons Attribution 4.0 International License.  \n©2025 Japanese Society of Physical Therapy  \nIntroduction  \nAs populations age, the number of patients with heart failure in developed countries, such as Japan, has continued to increase1) . Heart failure leads to various issues, including heightened mortality rates, decreased quality of life, and an increased healthcare burden2) . Furthermore, heart failure has been known to cause weight loss, muscle mass reduction, chronic inflammation, malnutrition, and extreme fatigue, which promote the development of cachexia3,4) . Cachexia, characterized by involuntary weight loss, has been observed in patients with various chronic diseases, including heart failure5) . Moreover, this condition has been identified as a significant independent risk factor for hospital readmissions6) and increased mortality rates due to heart failure7) .  \nHeart Failure Patients with and without Cachexia 189  \nTherefore, investigating the pathophysiological mechanisms of cachexia in patients with heart failure is crucial.  \nPrevious studies have reported that heart failure patients with cachexia have poorer physical function than those without cachexia8","cbCaik49wA7YHZqi","https://ap.wps.com/l/cbCaik49wA7YHZqi","pdf",305339,"English","# Introduction\n## Study rationale for cachexia in heart failure\n# Methods\n## Study design\n## Setting\n## Cachexia definition and assessments\n## Statistical analyses\n# Results\n## Patient characteristics by cachexia status\n## Physical function changes during hospitalization\n## Factors associated with cachexia\n# Conclusions","[{\"question\":\"How was cachexia defined at discharge in this study?\",\"answer\":\"Cachexia at discharge was defined using low body mass index combined with one or more of: low handgrip strength, elevated C-reactive protein, or anorexia.\"},{\"question\":\"What happened to physical function during hospitalization in patients with cachexia?\",\"answer\":\"Heart failure patients with cachexia showed no improvement in physical function from admission to discharge, unlike those without cachexia.\"},{\"question\":\"Which factors were associated with the presence of cachexia?\",\"answer\":\"Hierarchical logistic regression identified low GNRI and low muscle power as factors associated with cachexia in heart failure patients.\"}]","Recovery of Physical Function during Hospitalization among Heart Failure Patients with and without Cachexia | PDF",1790742216,25]