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Methods: This retrospective study evaluated early-stage clinically node-negative patients undergoing SLNB with frozen section at Salmaniya Medical Complex, Manama, Bahrain, from October 2021 to September 2023. Results: Among 147 patients, sensitivity was 84.6% with a 15.4% false-negative rate; 4.8% proceeded to immediate axillary dissection. Conclusion: Frozen section is unnecessary for most early breast cancer patients; permanent section alone may suffice without compromising standard care.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/reconsidering-the-need-for-intraoperative-frozen-section-in-sentinel-lymph-node-biopsy-for-early-breast-cancer-in-bahrain/340531/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/reconsidering-the-need-for-intraoperative-frozen-section-in-sentinel-lymph-node-biopsy-for-early-breast-cancer-in-bahrain/340531.png","ImageObject",300,407,{"name":92,"@type":93},"Evangeline","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the study’s main objective regarding frozen section in SLNB?","Question",{"text":112,"@type":113},"To assess whether intraoperative frozen section is needed during SLNB for patients with early breast cancer.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What diagnostic performance did the study report for frozen section during SLNB?",{"text":117,"@type":113},"Frozen section sensitivity was 84.6%, and the false-negative rate was 15.4%.",{"name":119,"@type":110,"acceptedAnswer":120},"Which patients may benefit from frozen section instead of using permanent section alone?",{"text":121,"@type":113},"Patients with multifocal or multicentric disease and those with tumours showing lymphovascular invasion, because they were more likely to require axillary dissection and a second operation.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},340531,1790080581,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":29,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},13056703019662,"https://ap-avatar.wpscdn.com/avatar/be000253a8e92610077?_k=1778726343310543188","Reconsidering the Need for Intraoperative Frozen Section in Sentinel Lymph Node Biopsy for Early Breast Cancer in Bahrain  \nAhmed Z. Salman,1 Noora F. Ali,1 Ali H. Abdulla,1 Sarah J. Alaraibi,1 Fatema A.Alkhabbaz,1 Maryam Hammad,2 *Hussain A. Abdulla1,3  \nabstract: Objectives: Frozen section is performed in sentinel lymph node biopsy (SLNB) for early breast cancer to prevent a second surgery, but it has certain disadvantages. Several trials have demonstrated the oncological safety of avoiding axillary dissection in patients with 1–2 positive nodes. This study aimed to assess the need for frozen section during SLNB in early breast cancer. Methods: This retrospective study included patients with early-stage clinically node-negative breast cancer who underwent SLNB with frozen section at Salmaniya Medical Complex, Manama, Bahrain, between October 2021 and September 2023. Patients who had neoadjuvant chemotherapy, cT3-4 tumours, ductal carcinoma in situ, occult breast cancer and previous breast cancer were excluded. Results: A total of 147 patients underwent breast cancer surgery with SLNB using frozen section. The sensitivity of frozen section was 84.6%, and the false-negative rate was 15.4%. Furthermore, 4.8% underwent immediate axillary dissection. In the remaining cases, there were only 1–2 positive sentinel nodes, and axillary dissection was omitted. Multifocal or multicentric disease was significantly associated with \u003C3 positive sentinel nodes (71.4% versus 15.0%; P = 0.005). Patients with an indication for axillary dissection were also more likely to have tumours with lymphovascular invasion compared to patients with ≥3 positive sentinel nodes (85.7% versus 17.1%; P = 0.001). Conclusion: There was no indication for frozen section is needed in most patients with early breast cancer. Routine frozen section is unnecessary during SLNB, and permanent section alone may be sufficient without compromising overall standard of care.  \nKeywords: Sentinel Lymph Node Biopsy; Frozen Sections; Axilla; Breast Cancer; Bahrain.  \nAdvances in Knowledge  \n- Sentinel lymph node biopsy (SLNB) is routinely performed at Salmaniya Medical Complex, Manama, Bahrain, usingfrozen section to prevent reoperation for axillary lymph node dissection (ALND). However, it is associated with a sensitivity of 84.6% andfalse-negative rate of 15.4%.  \n- Results showed that frozen section during SLNB only prevented a second operation in less than 5% of cases. Therefore, SLNB with permanent section alone may be sufficient.  \n- Only patients with multifocal or multicentric disease and tumours with lymphovascular invasion may benefitfrom frozen section as they are more likely to have ALND, thus preventing a second operation.  \nApplication to Patient Care  \n- Thesefindings will help establish a local policy to replacefrozen section with permanent section in most cases, thereby reducingprolonged operations and associated costs without impacting the overall standard ofcare.  \n- The need for frozen section should be limited to patients undergoing prolonged procedures, cases that underwent neoadjuvant chemotherapy and those that are athigh riskfor general anaesthesia or a second operation.  \nAxillary lymph node status is regarded  \nas one of the most important prognostic  \nfactors for patients with early breast cancer, particularly for adjuvant therapy decisions. Over the last 2 decades, sentinel lymph node biopsy (SLNB) has replaced axillary lymph node dissection (ALND) as the standard of care for axillary staging in early breast cancer and has reduced patient morbidity without compromising oncological outcomes.1 Current indications for SLNB in breast cancer include cT1-2 invasive tumours with clinically negative axilla.2 The American College of Surgeons Oncology Group Z0011 (ACOSOG Z011) trial reported that ALND is not  \nalways indicated even in patients with up to 2 positive sentinel lymph nodes (SLNs) who were treated with breast-conserving surgery (BCS) and adjuvant r","cbCaifbLlA1extR4","https://ap.wps.com/l/cbCaifbLlA1extR4","pdf",211369,"English","# Abstract\n## Objectives\n## Methods\n## Results\n## Conclusion\n# Advances in Knowledge\n## Routine use and diagnostic performance\n## When frozen section prevented a second operation\n## Subgroups potentially benefiting from frozen section\n# Application to Patient Care\n## Policy and operational impact\n## Patient selection criteria","[{\"question\":\"What was the study’s main objective regarding frozen section in SLNB?\",\"answer\":\"To assess whether intraoperative frozen section is needed during SLNB for patients with early breast cancer.\"},{\"question\":\"What diagnostic performance did the study report for frozen section during SLNB?\",\"answer\":\"Frozen section sensitivity was 84.6%, and the false-negative rate was 15.4%.\"},{\"question\":\"Which patients may benefit from frozen section instead of using permanent section alone?\",\"answer\":\"Patients with multifocal or multicentric disease and those with tumours showing lymphovascular invasion, because they were more likely to require axillary dissection and a second operation.\"}]","Reconsidering the Need for Intraoperative Frozen Section in Sentinel Lymph Node Biopsy for Early Breast Cancer in Bahrain | PDF",1790037124,15]