[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-333422-105":3,"doc-detail-333422-en":81,"detail-sidebar-cat-0-en-105":99},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","receptor-tyrosine-kinase-like-orphan-receptor-1-a-novel-antitumor-target-in-gastrointestinal-cancers","Receptor tyrosine kinase-like orphan receptor 1: A novel antitumor target in gastrointestinal cancers","","Receptor tyrosine kinase-like orphan receptor 1 (ROR1) belongs to the type I receptor tyrosine kinase family and plays key roles in embryonic development and cancer. As a biomarker and therapeutic target, ROR1 exists in soluble and membrane-bound forms, with the latter highly expressed in tumors. ROR1 is evolutionarily conserved and may contribute to gastrointestinal cancer via multiple signaling pathways and molecular mechanisms, including effects on tumor invasiveness, metastasis, cell-cycle regulation, and stem-cell characteristics. This review summarizes ROR1 structure, expression, and functions in gastrointestinal cancers, and evaluates current antitumor strategies, challenges, and future prospects.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/receptor-tyrosine-kinase-like-orphan-receptor-1-a-novel-antitumor-target-in-gastrointestinal-cancers/333422/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/receptor-tyrosine-kinase-like-orphan-receptor-1-a-novel-antitumor-target-in-gastrointestinal-cancers/333422.png","ImageObject",300,407,{"name":42,"@type":43},"Eliana","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-06","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",7,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is ROR1 and why is it important in cancer?","Question",{"text":63,"@type":64},"ROR1 is a type I receptor tyrosine kinase family member involved in embryonic development and cancer. It functions as a biomarker and a therapeutic target.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What ROR1 subtypes are discussed in the review?",{"text":68,"@type":64},"ROR1 has soluble and membrane-bound subtypes. The membrane-bound form is highly expressed in tumors, while the soluble form is minimally detectable in serum.",{"name":70,"@type":61,"acceptedAnswer":71},"How might ROR1 contribute to gastrointestinal cancer progression?",{"text":72,"@type":64},"The review suggests ROR1 may influence gastrointestinal cancer through multiple signaling pathways and molecular mechanisms, potentially promoting invasiveness, metastasis, and regulation of the cell cycle and stem-cell characteristics.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},333422,1790013112,{"code":4,"msg":82,"data":83},"success",{"doc_id":79,"user_id":84,"nickname":42,"user_avatar":85,"doc_module":4,"category_id":86,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":87,"file_id":88,"file_url":89,"file_type":90,"file_size":91,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":92,"language":93,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":94,"faqs":95,"seo_title":96,"seo_description":12,"update_tm":97,"read_time":98,"preview_page_count":4},4398048949847,"https://ap-avatar.wpscdn.com/avatar/400002536579ef2da7f?_k=1778318612642679267",8,"| W | J | C | O | World Journal of\u003Cbr>Clinical Oncology |\n| --- | --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Clin Oncol 2024 May 24; 15(5): 603-613  \nDOI: 10.5306/wjco.v15.i5.603 ISSN 2218-4333 (online)  \nMINIREVIEWS  \nReceptor tyrosine kinase-like orphan receptor 1: A novel antitumor target in gastrointestinal cancers  \nZheng-Long Wu, Ying Wang, Xiao-Yuan Jia, Yi-Gang Wang, Hui Wang  \nSpecialty type: Oncology  \nProvenance and peer review:  \nInvited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s classification Scientific Quality: Grade B  \nNovelty: Grade A  \nCreativity or Innovation: Grade B  \nScientific Significance: Grade A  \nP-Reviewer: Dharmawansa KVS, Canada  \nReceived: January 3, 2024  \nRevised: March 20, 2024  \nAccepted: April 17, 2024  \nPublished online: May 24, 2024  \nZheng-Long Wu, Ying Wang, Xiao-Yuan Jia, Yi-Gang Wang, Xinyuan Institute of Medicine and Biotechnology, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, Zhejiang Province, China  \nZheng-Long Wu, Hui Wang, Department of Oncology, Zhejiang Xiaoshan Hospital, Hangzhou 311201, Zhejiang Province, China  \nCorresponding author: Yi-Gang Wang, PhD, Professor, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, No. 928 2nd Street, Qiantang District, Hangzhou 310018, Zhejiang Province, [China.](China. wangyigang43@163.com)[ wangyigang43@163.com](China. wangyigang43@163.com)  \nAbstract  \nReceptor tyrosine kinase-like orphan receptor 1 (ROR1) is a member of the type I receptor tyrosine kinase family. ROR1 is pivotal in embryonic development and cancer, and serves as a biomarker and therapeutic target. It has soluble and membrane-bound subtypes, with the latter highly expressed in tumors. ROR1 is conserved throughout evolution and may play a role in the development of gastrointestinal cancer through multiple signaling pathways and molecular mechanisms. Studies suggest that overexpression of ROR1 may increase tumor invasiveness and metastasis. Additionally, ROR1 may regulate the cell cycle, stem cell characteristics, and interact with other signaling pathways to affect cancer progression. This review explores the structure, expression and role of ROR1 in the development of gastrointestinal cancers. It discusses current antitumor strategies, outlining challenges and prospects for treatment.  \nKey Words: Receptor tyrosine kinase-like orphan receptor 1; Gastrointestinal cancers; Therapeutic target; Molecular mechanisms; Antitumor strategies  \n©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.  \n WJCO  [https://www.wjgnet.com](https://www.wjgnet.com) 603 May 24, 2024  Volume 15  Issue 5   \nWu ZL et al. ROR1: Antitumor potential in gastrointestinal  \nCore Tip: Delve into a comprehensive review spotlighting receptor tyrosine kinase-like orphan receptor 1 (ROR1) pivotal involvement in gastrointestinal cancer advancement and its promising prospects as an anti-tumor remedy. Explore pivotal cellular pathways governing ROR1 regulation and pertinent insights into existing commercial therapeutic offerings. Emphasizing ROR1’s crucial role in gastrointestinal cancer treatment, this review offers a nuanced blend of historical context and scientific insight, illuminating the dynamic landscape of this evolving field.  \nCitation: Wu ZL, Wang Y, Jia XY, Wang YG, Wang H. Receptor tyrosine kinase-like orphan receptor 1: A novel antitumor target in gastrointestinal cancers. World J Clin Oncol 2024; 15(5): 603-613  \nURL: [https://www.wjgnet.com/2218-4333/full/v15/i5/603.htm](https://www.wjgnet.com/2218-4333/full/v15/i5/603.htm)  \nDOI: [https://dx.doi.org/10.5306/wjco.v15.i5.603](https://dx.doi.org/10.5306/wjco.v15.i5.603)  \nINTRODUCTION  \nReceptor tyrosine kinase-like orphan receptor (ROR) 1 and ROR2 belong to the ROR subfamily of type I receptor tyrosine kinase (RTK) family. They were fi","cbCaiuI9T7VRM56U","https://ap.wps.com/l/cbCaiuI9T7VRM56U","pdf",1123763,12,"English","# Introduction\n## ROR1 and ROR family background\n## ROR1 subtypes and expression in cancer\n# Core Tip\n# Abstract\n# Key Words","[{\"question\":\"What is ROR1 and why is it important in cancer?\",\"answer\":\"ROR1 is a type I receptor tyrosine kinase family member involved in embryonic development and cancer. It functions as a biomarker and a therapeutic target.\"},{\"question\":\"What ROR1 subtypes are discussed in the review?\",\"answer\":\"ROR1 has soluble and membrane-bound subtypes. The membrane-bound form is highly expressed in tumors, while the soluble form is minimally detectable in serum.\"},{\"question\":\"How might ROR1 contribute to gastrointestinal cancer progression?\",\"answer\":\"The review suggests ROR1 may influence gastrointestinal cancer through multiple signaling pathways and molecular mechanisms, potentially promoting invasiveness, metastasis, and regulation of the cell cycle and stem-cell characteristics.\"}]","Receptor tyrosine kinase-like orphan receptor 1: A novel antitumor target in gastrointestinal cancers | PDF",1790002374,30,{"code":4,"msg":82,"data":100},[101,105,109,113,118,123,127,129,134,137,141],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":106,"show_sort_weight":107,"slug":108},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":110,"show_sort_weight":111,"slug":112},"Exam",70,"exam",{"id":114,"doc_module":4,"doc_module_name":25,"category_name":115,"show_sort_weight":116,"slug":117},5,"Comic",60,"comic",{"id":119,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":121,"slug":122},6,"Technology",50,"technology",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":125,"slug":126},"Healthcare",40,"healthcare",{"id":86,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":98,"slug":128},"research-report",{"id":130,"doc_module":4,"doc_module_name":25,"category_name":131,"show_sort_weight":132,"slug":133},9,"Religion & Spirituality",20,"religion-spirituality",{"id":132,"doc_module":4,"doc_module_name":25,"category_name":135,"show_sort_weight":132,"slug":136},"World Cup","world-cup",{"id":138,"doc_module":4,"doc_module_name":25,"category_name":139,"show_sort_weight":138,"slug":140},10,"Lifestyle","lifestyle",{"id":142,"doc_module":4,"doc_module_name":25,"category_name":143,"show_sort_weight":114,"slug":144},19,"General","general"]