[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-367274-105":59,"doc-detail-367274-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","recent-update-of-natural-compounds-as-hif-1-inhibitors-in-colorectal-carcinoma","Recent Update of Natural Compounds as HIF-1α Inhibitors in Colorectal Carcinoma","","Hypoxia-inducible factor (HIF)-1 is a transcription factor that regulates target gene expression tied to oxygen homeostasis under hypoxic conditions, thereby supporting tumor development and progression. Evidence shows that HIF-1α controls processes such as angiogenesis, metastasis, metabolism, and immune evasion, making HIF-1α overexpression a marker of poor prognosis in cancer. Natural compounds are key anticancer drug sources, and HIF-1α pharmacological targeting is a growing therapeutic strategy.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/recent-update-of-natural-compounds-as-hif-1-inhibitors-in-colorectal-carcinoma/367274/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/recent-update-of-natural-compounds-as-hif-1-inhibitors-in-colorectal-carcinoma/367274.png","ImageObject",300,407,{"name":92,"@type":93},"Genevieve","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What role does HIF-1α play in colorectal cancer progression?","Question",{"text":113,"@type":114},"HIF-1α regulates pathways tied to hypoxia adaptation, including angiogenesis, metastasis, metabolism, and immune evasion, which contribute to tumor progression. Overexpression is strongly linked with poor prognosis.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Why are natural compounds considered important for anticancer therapy targeting HIF-1α?",{"text":118,"@type":114},"Natural compounds provide important sources of anticancer agents and can modulate HIF-1α. The review emphasizes their role as HIF-1α inhibitors in colorectal cancer contexts.",{"name":120,"@type":111,"acceptedAnswer":121},"What is the scope of the literature reviewed for identifying HIF-1α-related approaches?",{"text":122,"@type":114},"The review covers research publications related to the HIF-1α domain in cancer from 2010 to 2024. The main goal is to identify better targeted approaches for managing colorectal carcinoma.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},367274,1790194996,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},1374391974585,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Drug Design, Development and Therapy  \n Open Access Full Text Article  \nREVIEW  \nRecent Update of Natural Compounds as HIF-1 α Inhibitors in Colorectal Carcinoma  \nPratibha Pandey 1 , 2 , Sorabh Lakhanpal 3 , Danish Mahmood4 , Lalji Baldaniya 5 , Han Na Kang 6 , Sungho Hwang 7 , Sojin Kang 7 , Min Choi 7 , Seungjoon Moon 7 , Shivam Pandey8 , Kamlesh Chaudhary9 , Fahad Khan 10 , Bonglee Kim 6 , 7  \n1Centre for Research Impact & Outcome, Chitkara University Institute of Engineering and Technology, Chitkara University, Rajpura, Punjab, 140401, India; 2Chitkara Centre for Research and Development, Chitkara University, Baddi, Himanchal Pradesh, 174103, India; 3School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India; 4Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Buraydah, 51452, Saudi Arabia; 5Marwadi University Research Center, Department of Pharmaceutical Sciences, Faculty of Health Sciences, Marwadi University, Rajkot, Gujarat, 360003, India; 6KM Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea; 7Department of Pathology, College of Korean Medicine, Kyung Hee University, Hoegidong Dongdaemungu, Seoul, 05253, Republic of Korea; 8School of Applied and Life Sciences, Uttaranchal University, Dehradun, Uttarakhand, 248007, India; 9Department of Neurology, National Institute of Medical Sciences, NIMS University Rajasthan, Jaipur, Rajasthan, India; 10Center for Global Health Research, Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India  \nCorrespondence: Fahad Khan; Bonglee Kim, Email [fahadintegralian@gmail.com](fahadintegralian@gmail.com); [bongleekim@khu.ac.kr](bongleekim@khu.ac.kr)  \n\n| Abstract: Hypoxia-inducible factor (HIF)-1 is a transcription factor that regulates the expression of target genes associated with oxygen homeostasis under hypoxic conditions, thereby contributing to tumor development and progression. Accumulating evidence has demonstrated that HIF-1α mediates different biological processes, including tumor angiogenesis, metastasis, metabolism, and immune evasion. Thus, overexpression of HIF-1α is strongly associated with poor prognosis in cancer patients. Natural compounds are important sources of anticancer drugs and studies have emphasized the decisive role of these mediators in modulating HIF-1α . Therefore, the pharmacological targeting of HIF-1α has emerged as a novel cancer therapeutic approach in recent years. The novelty of this review is that it summarizes natural products targeting HIF-1α in colorectal cancer that have not been presented earlier. We studied research publications related to the HIF-1α domain in cancer from 2010 to 2024. However, our main focus was to identify a better targeted approach for colorectal carcinoma management. Our review described HIF-1α role in tumor progression, summarizes the natural compounds employed as HIF-1α inhibitors, and discusses their potential in the development of natural compounds as HIF-1α inhibitors for colorectal cancer treatment.\u003Cbr>Keywords: HIF-1α, colorectal cancer, natural compounds, inhibitors, hypoxia |\n| --- |\n| Introduction\u003Cbr>A significant advancement in cancer treatment over the last decade has been the emergence of targeted therapies. Unlike traditional chemotherapy, which indiscriminately kills cells, targeted therapy focuses on blocking specific proteins and genes.1,2 Targeted therapy is an innovative and elective strategy that effectively extends the overall lifespan of patients with colorectal cancer (CRC). New drugs that target many key pathways and immunological checkpoints have appeared rapidly after the successful use of anti-angiogenesis agents (bevacizumab) and anti-EGFR agents (cetuximab). Targeted medicines can effectively impede the growth, specialization, and movement of cancer cells. Targeted medications can modify the TME, including nearby blood arteries and immun","cbCaiiMzaChraGsf","https://ap.wps.com/l/cbCaiiMzaChraGsf","pdf",2636656,18,"English","# Abstract\n# Introduction","[{\"question\":\"What role does HIF-1α play in colorectal cancer progression?\",\"answer\":\"HIF-1α regulates pathways tied to hypoxia adaptation, including angiogenesis, metastasis, metabolism, and immune evasion, which contribute to tumor progression. Overexpression is strongly linked with poor prognosis.\"},{\"question\":\"Why are natural compounds considered important for anticancer therapy targeting HIF-1α?\",\"answer\":\"Natural compounds provide important sources of anticancer agents and can modulate HIF-1α. The review emphasizes their role as HIF-1α inhibitors in colorectal cancer contexts.\"},{\"question\":\"What is the scope of the literature reviewed for identifying HIF-1α-related approaches?\",\"answer\":\"The review covers research publications related to the HIF-1α domain in cancer from 2010 to 2024. The main goal is to identify better targeted approaches for managing colorectal carcinoma.\"}]","Recent Update of Natural Compounds as HIF-1α Inhibitors in Colorectal Carcinoma | PDF",1790170039,45]