[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-332924-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-332924-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","recent-advances-in-noncoding-rna-modifications-of-gastrointestinal-cancer","Recent advances in noncoding RNA modifications of gastrointestinal cancer","","Elucidating mechanisms driving cancer development and proliferation supports effective therapeutic design, including diagnostic markers for early detection and novel strategies for refractory gastrointestinal malignancies. Noncoding RNAs (ncRNAs) do not encode proteins yet regulate gene expression and cellular processes, with microRNA, long noncoding RNA, and circular RNA tightly linked to tumor progression. Technological advances enable base-level modification profiling, especially N6-methyladenosine (m6A), whose altered marks associate with disease progression. The review analyzes ncRNA modification roles in colorectal and pancreatic cancer and discusses m6A-targeting enzyme inhibitors for drug discovery potential.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/recent-advances-in-noncoding-rna-modifications-of-gastrointestinal-cancer/332924/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/recent-advances-in-noncoding-rna-modifications-of-gastrointestinal-cancer/332924.png","ImageObject",300,407,{"name":42,"@type":43},"Theodora","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",8,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"Why are ncRNA modifications important for gastrointestinal cancer research?","Question",{"text":63,"@type":64},"Noncoding RNAs regulate gene expression and cellular processes, and abnormal ncRNA modifications influence cancer progression. The review highlights these links, especially for colorectal and pancreatic cancers.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What is m6A and how is it involved in tumor progression?",{"text":68,"@type":64},"m6A (N6-methyladenosine) is a key RNA modification deposited onto RNAs via specific writer complexes. Reader proteins recognize these marks, and multiple studies associate m6A alterations with cancer progression.",{"name":70,"@type":61,"acceptedAnswer":71},"Which ncRNA modification types are discussed for gastrointestinal cancers?",{"text":72,"@type":64},"The review focuses on microRNA, long noncoding RNA, and circular RNA, along with RNA modifications centered on m6A. It also considers how modification states connect to molecular mechanisms in cancer cells.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},332924,1790181829,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,111,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":108,"show_sort_weight":109,"slug":110},7,"Healthcare",40,"healthcare",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":112,"slug":113},30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":55,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145,"preview_page_count":4},687197207919,"https://ap-avatar.wpscdn.com/avatar/a000253d6f5f7c60be?x-image-process=image/resize,m_fixed,w_180,h_180&k=1779446848396160552","Received: 31 July 2024 | Revised: 7 October 2024 | Accepted: 13 October 2024  \nDOI: 10. 1111/cas.16380  \nR E V I E W A RTI C LE  \nRecent advances in noncoding RNA modifications of gastrointestinal cancer  \nTomoaki Hara1 | Sikun Meng1 | Yasuko Arao1 | Yoshiko Saito1 | Kana Inoue1 | Sarah Rennie2 | Ken Ofusa1,3 | Yuichiro Doki4 | Hidetoshi Eguchi4  |  \nToru Kitagawa1,4,5 | Hideshi Ishii1,5   \n1Department of Medical Data Science, Center of Medical Innovation and Translational Research, Osaka University Graduate School of Medicine, Osaka, Japan 2Section for Computational and RNA Biology, Department of Biology, University of Copenhagen, Copenhagen, Denmark  \n3 Prophoenix Division, Food and Life-Science Laboratory, IDEA Consultants, Inc. , Osaka, Osaka, Japan 4Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Osaka, Japan 5Kyowa-kai Medical Corporation, Kawanishi, Hyogo, Japan  \nCorrespondence  \nHideshi Ishii and Tomoaki Hara, Department of Medical Data Science, Center of Medical Innovation and Translational Research, Osaka University Graduate School of Medicine, Osaka 565- 0871, Japan.  \nEmail: [hishii@gesurg. med.osaka-u.ac.jp](hishii@gesurg. med.osaka-u.ac.jp)  \nand [thara@cfs. med.osaka-u.ac.jp](thara@cfs. med.osaka-u.ac.jp)  \nFunding information  \nMitsubishi Foundation, Grant/Award Number: 2021-48; Agency for Cultural Affairs, Government of Japan, Grant/ Award Number: 17cm0106414h0002; JP21lm0203007; JP23ym0126809, 19 K22658; 20H00541; 21 K19526;  \n22H03146 and 22 K19559; 23K18313; 16H06279 [PAGS]; Takahashi Industrial and Economic Research Foundation, Grant/Award Number: 2023  \nAbstract  \nElucidating the mechanisms underlying cancer development and proliferation is important for the development of therapeutic methods for the complete cure of cancer. In particular, the identification of diagnostic markers for early detection and new therapeutic strategies for refractory gastrointestinal cancers are needed. Various abnormal phenomena occur in cancer cells, such as functional changes of proteins, led by genomic mutations, and changes in gene expression due to dysregulation of epigenetic regulation. This is no exception for noncoding RNA (ncRNA), which do not encode proteins. Recent reports have revealed that microRNA (miRNA), long noncoding RNA (lncRNA), and circular RNA (circRNA) are deeply involved in cancer progression. These ncRNAshave attracted attention as gene expression regulatory molecules. Recent advances in technology have made it possible not only to read DNA and RNA sequences but also to study the modification state of each base. In particular, comprehensive analysis of N6-methyladenosine (m6A) has been performed by many research groups, with multiple studies reporting that m6A modifications of specific genes are associated with cancer progression. Based on the above, this review examines how ncRNA modifications are related to cancer progression in gastrointestinal cancers such as colorectal and pancreatic cancer. We also discuss enzyme inhibitors that have been reported to have drug discovery potential targeting m6A modifications. By utilizing the new perspective of  \n\n| Abbreviations: 5FU, 5-fluorouracil; AML, acute myeloid leukemia; ceRNA, competing endogenous RNA; circRNA, circular RNA; CRC, colorectal cancer; EMT, epithelial-to-mesenchymal transition; GC, gastric cancer; GISTs, gastrointestinal stromal tumors; lncRNA, long noncoding RNA; m1A, N1-methyladenine; m5C, 5-methylcytosine; m6A, N6-methyladenosine; MeRIP-seq, methylated RNA immunoprecipitation sequencing; miRNA, microRNA; NFIC, nuclear factor I-C; PC, pancreatic cancer; PGF, placental growth factor; SNPs, singlenucleotide polymorphisms; TAMs, tumor-associated macrophages. |\n| --- |\n| [Correction added on 7 November 2024, after first online publication. The affiliation of the author Toru Kitagawa has been corrected in this version.] |\n\nThis is an open access article under the terms of the Creative Commons Attributio","cbCairiCaq3sUbfS","https://ap.wps.com/l/cbCairiCaq3sUbfS","pdf",510966,13,"English","# Abstract\n# Keywords\n# Background\n## Classification and roles of ncRNA\n## m6A writers and recognition systems\n# Funding information","[{\"question\":\"Why are ncRNA modifications important for gastrointestinal cancer research?\",\"answer\":\"Noncoding RNAs regulate gene expression and cellular processes, and abnormal ncRNA modifications influence cancer progression. The review highlights these links, especially for colorectal and pancreatic cancers.\"},{\"question\":\"What is m6A and how is it involved in tumor progression?\",\"answer\":\"m6A (N6-methyladenosine) is a key RNA modification deposited onto RNAs via specific writer complexes. Reader proteins recognize these marks, and multiple studies associate m6A alterations with cancer progression.\"},{\"question\":\"Which ncRNA modification types are discussed for gastrointestinal cancers?\",\"answer\":\"The review focuses on microRNA, long noncoding RNA, and circular RNA, along with RNA modifications centered on m6A. It also considers how modification states connect to molecular mechanisms in cancer cells.\"}]","Recent advances in noncoding RNA modifications of gastrointestinal cancer | PDF",1790000015,33]