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Drug resistance and cancer regrowth continue to limit current therapies, creating a need for novel agents with favorable properties. The review focuses on how colon cancer cells rely on a high basal level of reactive oxygen species (ROS) for cellular functions, while excess intracellular ROS can trigger apoptotic death by disrupting redox homeostasis. Plant-derived alkaloids are highlighted as phytocompounds that may enhance ROS and modulate targets including IGF-1, with reported potent anti-colon cancer effects and low toxicity to normal cells.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/reactive-oxygen-species-mediated-apoptotic-death-of-colon-cancer-cells-therapeutic-potential-of-plant-derived-alkaloids/378088/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/reactive-oxygen-species-mediated-apoptotic-death-of-colon-cancer-cells-therapeutic-potential-of-plant-derived-alkaloids/378088.png","ImageObject",300,407,{"name":92,"@type":93},"Quinn Holloway","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-28","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is ROS important in colon cancer cells?","Question",{"text":112,"@type":113},"Colon cancer cells require a high basal level of reactive oxygen species (ROS) to maintain cellular functions. However, excessive intracellular ROS can drive cancer cell death by disturbing cellular redox homeostasis and triggering apoptosis.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What major problems affect current colorectal cancer treatments?",{"text":117,"@type":113},"Current approaches face serious challenges such as drug resistance and subsequent cancer regrowth, and there has been no significant decrease in cancer patient mortality.",{"name":119,"@type":110,"acceptedAnswer":120},"How might plant-derived alkaloids help as therapies?",{"text":121,"@type":113},"The review explains that plant-derived alkaloids may enhance intracellular ROS and induce apoptotic cell death by modulating multiple molecular targets, including IGF-1, while showing negligible toxicity toward normal cells.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},378088,1790526563,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},2336474466712,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","TYPE Review  \nPUBLISHED 25 July 2023  \nDOI 10.3389/fendo.2023.1201198  \nOPEN ACCESS  \nEDITED BY  \nDipak Kumar Sahoo,  \nIowa State University, United States  \nREVIEWED BY  \nAhmad Perwez,  \nCase Western Reserve University, United States  \nSuvranil Ghosh,  \nUniversity of Texas Southwestern Medical Center, United States  \n*CORRESPONDENCE Vinod K. Nelson  \n[vinod.kumar457@gmail.com](vinod.kumar457@gmail.com)[ ](vinod.kumar457@gmail.com)Niraj Kumar Jha  \n [niraj.jha@sharda.ac.in](niraj.jha@sharda.ac.in)[ ](niraj.jha@sharda.ac.in)Petr Slama  \n [petr.slama@mendelu.cz](petr.slama@mendelu.cz)[ ](petr.slama@mendelu.cz)Shubhadeep Roychoudhury  \n [shubhadeep1@gmail.com](shubhadeep1@gmail.com)  \n†These authors have contributed equally to this work and share first authorship  \n‡These authors have contributed equally to this work and share second authorship  \nRECEIVED 06 April 2023  \nACCEPTED 28 June 2023  \nPUBLISHED 25 July 2023  \nCITATION  \nNelson VK, Nuli MV, Mastanaiah J,  \nSaleem T. S. M, Birudala G, Jamous YF, Alshargi O, Kotha KK, Sudhan HH, Mani RR, Muthumanickam A, Niranjan D, Jain NK, Agrawal A, Jadon AS, Mayasa V, Jha NK, Kolesarova A, Slama P and Roychoudhury S (2023) Reactive oxygen species  \nmediated apoptotic death of colon cancer cells: therapeutic potential of plant derived alkaloids.  \nFront. Endocrinol. 14:1201198 .  \ndoi: 10.3389/fendo.2023.1201198  \nCOPYRIGHT  \n© 2023 Nelson, Nuli, Mastanaiah, Saleem T. S., Birudala, Jamous, Alshargi, Kotha, Sudhan, Mani, Muthumanickam, Niranjan, Jain, Agrawal, Jadon, Mayasa, Jha, Kolesarova, Slama and Roychoudhury. This is an openaccess article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nReactive oxygen species mediated apoptotic death of colon cancer cells:  \ntherapeutic potential of plant derived alkaloids  \nVinod K. Nelson 1*†, Mohana Vamsi Nuli 1†, Juturu Mastanaiah 2‡, Mohamed Saleem T. S. 3‡, Geetha Birudala 4, Yahya F. Jamous 5, Omar Alshargi 3, Kranthi Kumar Kotha 6, Hari Hara Sudhan 1, Ravishankar Ram Mani 7, Alagusundaram Muthumanickam 8, Divya Niranjan 8, Nem Kumar Jain 8, Ankur Agrawal 8,  \nArvind Singh Jadon 9, Vinyas Mayasa 10, Niraj Kumar Jha 11,12,13,14*, Adriana Kolesarova 15, Petr Slama 16*  \nand Shubhadeep Roychoudhury 17*  \n1 Raghavendra Institute of Pharmaceutical Education and Research, Anantapur, India, 2 Department of Pharmacology, Balaji College of Pharmacy, Anantapur, India, 3College of Pharmacy, Riyadh ELM University, Riyadh, Saudi Arabia, 4 Faculty of Pharmacy, Dr. M. G. R. Educational and Research Institute, Chennai, India, 5Vaccines and Bioprocessing Centre, King Abdulaziz City for Science and Technology (KACST), Riyadh, Saudi Arabia, 6 Department of Pharmaceutics, College of Pharmaceutical Sciences, Dayananda Sagar University, Bengaluru, India, 7 Faculty of Pharmaceutical Sciences, UCSI University, Kuala Lumpur, Malaysia, 8School of Pharmacy, ITM University, Gwalior, India, 9Amity Institute of Pharmacy, Amity University, Gwalior, India, 10GITAM School of Pharmacy, GITAM University Hyderabad Campus, Rudraram, India, 11 Department of Biotechnology, School of Engineering and Technology, Sharda University, Greater Noida, India, 12 Department of Biotechnology, School of Applied & Life Sciences (SALS), Uttaranchal University, Dehradun, India, 13School of Bioengineering & Biosciences, Lovely Professional University, Phagwara, India, 14 Department of Biotechnology Engineering and Food Technology, Chandigarh University, Mohali, India, 15 Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture in Nitra, Nitra, Slovakia, 16 Laboratory of Animal Immunology and Biotechnology, Depa","cbCairKybPKwAiJk","https://ap.wps.com/l/cbCairKybPKwAiJk","pdf",5620459,21,"English","# Overview of colorectal cancer challenges\n## Risk factors and treatment limitations\n## Need for novel therapeutic agents\n# ROS and redox homeostasis in colon cancer\n## Basal ROS dependence\n## Excess ROS-induced apoptosis\n# Plant-derived alkaloids as therapeutic candidates\n## Mechanistic rationale via ROS enhancement\n## Target modulation (including IGF-1)\n## Evidence from preclinical and clinical studies","[{\"question\":\"Why is ROS important in colon cancer cells?\",\"answer\":\"Colon cancer cells require a high basal level of reactive oxygen species (ROS) to maintain cellular functions. However, excessive intracellular ROS can drive cancer cell death by disturbing cellular redox homeostasis and triggering apoptosis.\"},{\"question\":\"What major problems affect current colorectal cancer treatments?\",\"answer\":\"Current approaches face serious challenges such as drug resistance and subsequent cancer regrowth, and there has been no significant decrease in cancer patient mortality.\"},{\"question\":\"How might plant-derived alkaloids help as therapies?\",\"answer\":\"The review explains that plant-derived alkaloids may enhance intracellular ROS and induce apoptotic cell death by modulating multiple molecular targets, including IGF-1, while showing negligible toxicity toward normal cells.\"}]","Reactive oxygen species mediated apoptotic death of colon cancer cells - therapeutic potential of plant derived alkaloids | PDF",1790228391,53]