[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-364506-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-364506-en":131},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","rationales-of-cold-plasma-jet-therapy-in-skin-cancer","Rationales of Cold Plasma Jet Therapy in Skin Cancer","","Skin cancer affects millions worldwide and incidence continues to rise, with varying effectiveness and tolerability across major tumour subtypes including basal cell carcinoma, cutaneous squamous cell carcinoma, melanoma and actinic keratosis. Cold medical gas plasma generates reactive oxygen and nitrogen species at near-body temperature, with many approved jet-plasma options already considered safe in clinical use and trials. This review summarizes approved jet plasmas for skin cancer, detailing key mechanisms and treatment concepts and proposing integration into current dermato-oncology care.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/rationales-of-cold-plasma-jet-therapy-in-skin-cancer/364506/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/rationales-of-cold-plasma-jet-therapy-in-skin-cancer/364506.png","ImageObject",300,407,{"name":42,"@type":43},"Noah","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-02","2026-09-23",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",13,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What problem does the review address regarding skin cancer therapies?","Question",{"text":63,"@type":64},"Skin cancer incidence is increasing and existing subtype-targeted therapies differ in effectiveness and tolerability, motivating new complementary treatment strategies.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What is cold medical gas plasma and why is it relevant to skin cancer?",{"text":68,"@type":64},"Cold medical gas plasma is a partially ionised gas operated near body temperature that simultaneously generates reactive oxygen and nitrogen species, enabling medical applications in dermatology and dermato-oncology.",{"name":70,"@type":61,"acceptedAnswer":71},"How does the review structure its discussion of cold plasma jet therapy?",{"text":72,"@type":64},"It summarizes existing work on gas plasma treatment, focusing on approved jet plasmas in skin cancer, and outlines central mechanisms and treatment concepts, including how to integrate this approach into current therapy 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in Skin Cancer  \nSander Bekeschus1,2 | Debora Singer1,2 | Gishan Ratnayake3 | Klaus Ruhnau4 | Kostya Ostrikov5 | Erik W. Thompson6,7  \n1Department of Dermatology and Venerology, Rostock University Medical Center, Rostock, Germany | 2ZIK Plasmatis, Leibniz Institute for Plasma Science and Technology (INP), Greifswald, Germany | 3Department of Radiation Oncology, Princess Alexandra Hospital, Brisbane, Queensland, Australia | 4neoplas MED, Greifswald, Germany | 5School of Chemistry and Physics and Centre for Biomedical Technologies, Queensland University of Technology, Brisbane, Queensland, Australia | 6School of Biomedical Sciences and Centre for Genomics and Personalised Health, Queensland University of  \nTechnology, Brisbane, Queensland, Australia | 7Translational Research Institute, Brisbane, Queensland, Australia Correspondence: Sander Bekeschus (sander.bekeschus@med.uni-rostock.de)  \nReceived: 15 March 2024 | Revised: 4 February 2025 | Accepted: 6 February 2025  \nFunding: G.R. acknowledges funding from a Metro South Health Research Support Scheme (MSH RSS) Early Career Researcher Grant, Queensland, Australia. K.O. acknowledges partial support from the Alexander von Humboldt Foundation. D.S. acknowledges funding from the Rostock Academy of Science (RAS, Rostock University Medical Center, Rostock, Germany) .  \nKeywords: actinic keratosis | AK | basal cell carcinoma | BCC | combination therapies | malignant melanoma | SCC | squamous cell carcinoma | tumour wound  \nABSTRACT  \nSkin cancer affects millions of patients worldwide, and its incidence is increasing. Current therapies targeting skin tumour subtypes, such as basal cell carcinoma, cutaneous squamous cell carcinoma, melanoma and actinic keratosis, vary in their degree of effectiveness and tolerability, motivating new research avenues on complementing treatment strategies. Cold medical gas plasma is a partially ionised gas operated at about body temperature and generates various reactive oxygen and nitrogen species simultaneously. A range of medical gas plasma devices has proven safe in thousands of patients and is an approved medical product for dermatology conditions, such as nonhealing wounds, in Europe and, more broadly, for clinical trials. Extending potential gas plasma applications in the field of dermato-oncology is therefore plausible, especially in light of the strong preclinical evidence and early clinical data. This review summarises existing work on gas plasma treatment, focusing on approved jet plasmas in skin cancer and outlining central mechanisms and treatment concepts. It also provides a concrete perspective on integrating medical gas plasma treatment into existing skin cancer therapy schemes, encouraging translational scientists and clinicians to enable gas plasma-assisted cancer care through clinical research.  \n1 | Introduction  \nSkin cancer affects millions of patients worldwide, and its incidence is increasing [1, 2] . The disease is classified into several subtypes. The most frequent is basal cell carcinoma (BCC) . At late diagnosis, BCCs have a strongly invasive phenotype but rarely metastasize to distant body parts. Cumulative exposure to UV light throughout life strongly correlates with disease onset, but BCC lesions can also occur in areas of the body exposed to less sunlight. Sunlight exposure is also a major driver for the  \nsecond-most frequent type of skin cancer, cutaneous squamous cell carcinoma (cSCC) . In many cases, cSCCs develop from precancerous malignant lesions referred to as actinic keratosis (AK), carcinoma in situ. AKs are dry, scaly patches, usually at body locations frequently exposed to sunlight. AKs are not classified as skin cancer per se due to their lack of invasiveness, but they occur often. For example, about 50% of people over 60 years old are thought to have at least one AK lesion, making AK treatments a significant issue in the healthcare systems across ","cbCaisDy3sau5Wae","https://ap.wps.com/l/cbCaisDy3sau5Wae","pdf",615240,"English","# Introduction\n## Skin cancer subtypes and current treatment challenges\n## Cold medical gas plasma and its clinical relevance\n# Review scope and integration perspective\n## Approved jet plasmas and core mechanisms","[{\"question\":\"What problem does the review address regarding skin cancer therapies?\",\"answer\":\"Skin cancer incidence is increasing and existing subtype-targeted therapies differ in effectiveness and tolerability, motivating new complementary treatment strategies.\"},{\"question\":\"What is cold medical gas plasma and why is it relevant to skin cancer?\",\"answer\":\"Cold medical gas plasma is a partially ionised gas operated near body temperature that simultaneously generates reactive oxygen and nitrogen species, enabling medical applications in dermatology and dermato-oncology.\"},{\"question\":\"How does the review structure its discussion of cold plasma jet therapy?\",\"answer\":\"It summarizes existing work on gas plasma treatment, focusing on approved jet plasmas in skin cancer, and outlines central mechanisms and treatment concepts, including how to integrate this approach into current therapy schemes.\"}]","Rationales of Cold Plasma Jet Therapy in Skin Cancer | PDF",1790157857,48]