[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-86611-en":3,"doc-seo-86611-105":30,"detail-sidebar-cat-0-en-105":92},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"doc_content":15,"file_id":16,"file_url":17,"file_type":18,"file_size":19,"view_count":20,"is_deleted":4,"is_public":21,"is_downloadable":21,"audit_status":21,"page_count":22,"language":23,"language_code":24,"site_id":25,"html_lang":24,"table_of_contents":26,"faqs":27,"seo_title":13,"seo_description":14,"update_tm":28,"read_time":29},86611,34359740700684,"Finn","https://ap-avatar.wpscdn.com/avatar/1f400023980c374ae676?_k=1777273430885731487",8,"Research & Report","Rare Sugar D-Psicose Protects Pancreatic β-Islets and Improves Insulin Resistance in OLETF Rats","Rare sugar D-psicose is investigated as a non-toxic compound that protects and preserves pancreatic β-islets, thereby improving insulin resistance in type 2 diabetes mellitus. The study uses Otsuka Long-Evans Tokushima Fatty (OLETF) rats, with 5% D-psicose or 5% D-glucose given in drinking water for 13 weeks. D-psicose markedly reduces β-islet fibrosis and preserves islets by histology and immunostaining, lowers body weight and abdominal fat, and improves oral glucose tolerance, supporting maintenance of hyperglycemia and prevention of fat accumulation.","| Rare sugar D-psicose protects pancreas b-islets and thus improves insulin resistance in OLETF rats\u003Cbr>Akram Hossain a, Fuminori Yamaguchi a, Toru Matsunaga b, Yuko Hirata a, Kazuyo Kamitori a, Youyi Dong a, Li Sui a, Ikuko Tsukamoto c, Masaki Ueno d, Masaaki Tokuda a, ⇑\u003Cbr>a Department of Cell Physiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki, Kita, Kagawa 761-0793, Japan b Division of Hospital Pathology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki, Kita, Kagawa 761-0793, Japan c Department of Pharmaco-Bio-Informatics, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki, Kita, Kagawa 761-0793, Japan d Department of Inflammation Pathology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki, Kita, Kagawa 761-0793, Japan |  |  |\n| --- | --- | --- |\n| a r t i c l e i n f o |  | a b s t r a c t |\n| Article history:\u003Cbr>Received 21 July 2012\u003Cbr>Available online 1 August 2012 |  | Rare sugar D-psicose has cropped up as a non-toxic and effective compound to protect and preserve pancreatic b-islets in the growing type 2 diabetes mellitus (T2DM) rats through the regulation of glucose and fat metabolism. The present study was undertaken to examine the effect of rare sugar D-psicose on the protection of pancreatic b-islets using Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a T2DM model. Treated rats were fed with 5% D-psicose or 5% D-glucose supplemented drinking water, and only water in the control for 13 weeks. A non-diabetic Long-Evans Tokushima Otsuka (LETO), fed with water served asa counter control of OLETF. D-Psicose significantly attenuated progressive b-islet fibrosis and preserved islets, evaluated by hematoxylin–eosin staining, Masson’s trichrome staining and immunostainings of insulin and a-smooth muscle actin (SMA). D-Psicose significantly reduced increase in body weight and abdominal fat deposition. Oral glucose tolerance test (OGTT) showed reduced blood glucose levels suggesting the improvement of insulin resistance. All these data suggests that D-psicose protected and preserved pancreatic b-islets through the maintenance of hyperglycemia and by the prevention of fat accumulation in OLETF rats.\u003Cbr>􀀂 2012 Elsevier Inc. All rights reserved. |\n| Keywords:\u003Cbr>Rare sugar D-psicose Type 2 diabetes mellitus Pancreas b-islet Insulin resistance HOMA-IR |  |  |\n\n1. Introduction  \nPrevalence of global obesity has been increasing with alarming health problems day by day. Obesity is characterized by excess accumulation of fat and is associated with multiple complications, including T2DM [1] which also becomes a health problem and is thought to typically develop after age 40, but it is now increasingly seen in younger ages as obesity increases and physical activity decreases.  \nIn T2DM the body either does not produce enough insulin or there is insulin resistance resulting in the failure of sugar movement into the cells [2]. Initially, pancreatic b-islets produce more insulin to overcome the hyperglycaemic state resulting in islet hypertrophy that gradually proceeds to b-cell failure [3] and progressive failure leads to glucose intolerance followed by T2DM. Studies with rodents showed that decrease in b-cell mass play important roles in the pathogenesis of human T2DM [2]. If remains untreated, the consequences of T2DM can be life-threatening. Although there is no cure for T2DM, but it is manageable or even  \n⇑ Corresponding author. Fax: +81 87 891 2096.  \nE-mail address: [tokuda@med.kagawa-u.ac.jp](tokuda@med.kagawa-u.ac.jp) (M. Tokuda).  \npreventable, starting by eating healthy foods, exercising and maintaining body weight. Therefore, it is important to seek effective therapeutic interventions for the prevention and treatment of diabetes and its complications. Under these circumstances, the use of alternative medicines has increasingly become the focus of attention. And thus we introduce D-psicose, a non-toxic zero-calorie rare sweet monosaccharide as an effective agent against ","cbCaipU2HWl4JWLX","https://ap.wps.com/l/cbCaipU2HWl4JWLX","pdf",1731067,5,1,7,"English","en",105,"# Introduction\n# Materials and methods\n## Animals","[{\"question\":\"What is D-psicose and why is it studied for type 2 diabetes?\",\"answer\":\"The study assesses β-islet preservation and fibrosis using hematoxylin–eosin and Masson’s trichrome staining, plus immunostaining for insulin and α-smooth muscle actin (SMA).\"},{\"question\":\"How does D-psicose affect metabolic outcomes like insulin resistance and fat accumulation?\",\"answer\":\"D-psicose reduces body weight and abdominal fat deposition and improves oral glucose tolerance, indicating lowered blood glucose and improved insulin resistance in OLETF rats.\"},{\"question\":\"What conclusion does the study support regarding the mechanism of D-psicose?\",\"answer\":\"The data suggest D-psicose protects and preserves pancreatic β-islets by maintaining hyperglycemia at controlled levels and preventing fat accumulation, which together reduce progressive islet 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