[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-373393-105":59,"doc-detail-373393-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","rare-metastasis-of-renal-cell-carcinoma-to-the-breast-a-case-report","Rare metastasis of renal cell carcinoma to the breast - a case report","","Renal cell carcinoma is an aggressive malignancy that most often metastasizes to the lungs, bones, and liver, while breast metastasis remains uncommon, representing only a small fraction of breast neoplasms. This case report documents a 54-year-old woman who developed a metastatic breast lesion six years after radical nephrectomy. Imaging findings were confirmed by histopathology and immunohistochemistry as metastatic RCC, and wide local excision was performed without unnecessary axillary surgery.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/rare-metastasis-of-renal-cell-carcinoma-to-the-breast-a-case-report/373393/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/rare-metastasis-of-renal-cell-carcinoma-to-the-breast-a-case-report/373393.png","ImageObject",300,407,{"name":92,"@type":93},"Taylor Morgan","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-01","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is metastatic renal cell carcinoma to the breast difficult to detect?","Question",{"text":112,"@type":113},"Breast metastasis from RCC is rare, so it can be mistaken for a primary breast carcinoma. Careful diagnostic evaluation is needed to avoid inappropriate or overly aggressive surgery.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What confirmed that the breast lesion was metastatic RCC?",{"text":117,"@type":113},"Histopathology and immunohistochemical staining confirmed metastatic renal cell carcinoma, with positive markers including PAX8, CD10, and MNF116.",{"name":119,"@type":110,"acceptedAnswer":120},"What treatment approach was used for the patient’s breast lesion?",{"text":121,"@type":113},"A wide local excision was performed after localization of the lesion, and no axillary surgery was undertaken. Systemic therapy was discussed but not pursued later.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},373393,1790740017,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":81,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":39},1099523885336,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Oxford Medical Case Reports, 2025, 5, 311–313  \n[https://doi.org/10.1093/omcr/omaf029](https://doi.org/10.1093/omcr/omaf029)  \nCase Report  \nRare metastasis of renal cell carcinoma to the breast: a case report  \nAman Saswat Sahoo 1 , *, Bhuvi Singh1 , Monther Salman1 , Lilia Ragad2 , Rasheed Elayyan2  \n1University of Central Lancashire, School of Medicine and Dentistry  \n2 King’s College Hospital, Breast Surgery Department  \n*Corresponding author. Friargate Court, 154 Market Street West, Preston PR1 2EU, The United Kingdom. E-mail: [assahoo@uclan.ac.uk](assahoo@uclan.ac.uk)  \nAbstract  \nRenal cell carcinoma is an aggressive urological malignancy, accounting for 2%–3% of adult cancers and over 90% of renal cancers. While renal cell carcinoma commonly metastasizes to organs such as the lungs,bones, and liver, breast metastasis is rare, comprising only 0.5% to 2% of all breast neoplasms. This case report describes a 54-year-old female with a history of RCC who developed a metastatic lesion in her breast six years after radical nephrectomy. The lesion, initially detected via routine imaging, was confirmed as renal cell carcinoma through histopathology and immunohistochemistry. A wide local excision was performed, avoiding unnecessary axillary surgery. This case highlights the need for meticulous diagnostic evaluation to distinguish between primary breast carcinoma and metastatic disease, particularly in patients with a history of renal cell carcinoma. The rarity of renal cell carcinoma metastasis to the breast calls for further research to guide appropriate management.  \nKeywords: breast cancer; renal cell carcinoma; breast metastasis; nephrological malignancy; secondary breast neoplasm  \nIntroduction  \nRenal cell carcinoma (RCC) is a prevalent and aggressive urological malignancy that accounts for approximately 2%–3% of adult neoplasms and more than 90% of all renal cancers [1]. RCC usually metastasizes to the lungs (70%), bones (42%), lymph nodes (55%), liver (41%), and brain (11%) . Metastasis to the breast, however, is a rare phenomenon and accounts for 0. 5% to 2% of all breast neoplasms [2] .  \nBreast metastases usually originate from melanoma, lymphoma, or leukaemia making metastasis from RCC an exceptionally rare occurrence [3] . The presence of RCC in the breast indicates widespread dissemination of malignancy. The prognosis of metastatic RCC is generally poor compared to that of localised disease [4 , 5] . Due to its rarity the metastasis of RCC to the breast can be overlooked for a primary breast carcinoma, hence necessitating meticulous diagnosis which will avoid extreme surgical interventions such as mastectomy.  \nWe present herein a rare case of a 54-year-old female who presented to us with an RCC metastasis to her breast 6 years after her initial diagnosis.  \nCase presentation  \nA 54-year-old female had a history of RCC treated Initially by radical nephrectomy and no chemotherapy.  \nThe patient has had regular computer tomography (CT) imaging since her surgery. 3 years ago, a routine CT identified a 4 mm lesion in the lower outer quadrant of the right breast.  \nFigure 1. RCC (lesion circled) and LCC mammogram of the lesion.  \nFollowing this CT scan, a triple assessment has been performed. A clinical examination revealed no palpable abnormalities in both breasts. However, mammography highlighted a 6 mm circumscribed nodule in the posterolateral aspect of the right breast, which was not present in prior imaging 4 years ago (Figs 1 and 2) .  \nUltrasound evaluation correlated these findings with a 5 mm benign-appearing nodule (Fig. 3) .  \nCore Biopsy was performed, and histopathological evaluation showed an inflammatory lesion, characterised by cells with clear cytoplasm and macrophages. Keeping in mind the initial known diagnosis; immunohistochemical staining provided crucial diagnostic clarity, with positive results for PAX8, CD10,  \nReceived: August 24, 2024 . Revised: December 20, 2024 . Accepted: February 21, 2025 ","cbCaimdIqSyIHQxY","https://ap.wps.com/l/cbCaimdIqSyIHQxY","pdf",573162,"English","# Abstract\n# Introduction\n# Case presentation\n## Diagnostic workup\n## Treatment and outcome\n# Discussion","[{\"question\":\"Why is metastatic renal cell carcinoma to the breast difficult to detect?\",\"answer\":\"Breast metastasis from RCC is rare, so it can be mistaken for a primary breast carcinoma. Careful diagnostic evaluation is needed to avoid inappropriate or overly aggressive surgery.\"},{\"question\":\"What confirmed that the breast lesion was metastatic RCC?\",\"answer\":\"Histopathology and immunohistochemical staining confirmed metastatic renal cell carcinoma, with positive markers including PAX8, CD10, and MNF116.\"},{\"question\":\"What treatment approach was used for the patient’s breast lesion?\",\"answer\":\"A wide local excision was performed after localization of the lesion, and no axillary surgery was undertaken. Systemic therapy was discussed but not pursued later.\"}]","Rare metastasis of renal cell carcinoma to the breast - a case report | PDF",1790199476]