[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-340552-105":59,"doc-detail-340552-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","rare-histiocytic-neoplasm-a-case-report","Rare histiocytic neoplasm - A case report","","Histiocytic neoplasms are rare hematologic disorders characterized by an excessive accumulation of histiocytes across tissues such as skin, bone, lymph nodes, and the central nervous system. They account for less than 1% of cancers in soft tissues and lymph nodes and are categorized into more than 100 subtypes across five groups. A 76-year-old male presented with intramedullary thoracic Langerhans cell histiocytosis (LCH), showing progressive paraparesis and MRI-confirmed intradural intramedullary involvement.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/rare-histiocytic-neoplasm-a-case-report/340552/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/rare-histiocytic-neoplasm-a-case-report/340552.png","ImageObject",300,407,{"name":92,"@type":93},"Clementine","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What are histiocytic neoplasms and how common are they?","Question",{"text":112,"@type":113},"They are defined by abnormal accumulation of histiocytes in multiple tissues, including the skin, bones, lymph nodes, and the central nervous system. They represent less than 1% of cancers in soft tissues and lymph nodes.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What condition was identified in the case report and where was it located?",{"text":117,"@type":113},"The patient had an isolated intramedullary thoracic Langerhans cell histiocytosis. Imaging showed an intradural intramedullary nodule at the T5 level.",{"name":119,"@type":110,"acceptedAnswer":120},"How was the lesion treated and what was the outcome?",{"text":121,"@type":113},"The patient underwent a T4–T6 laminectomy for complete resection of the lesion. The abstract indicates successful excision of the intramedullary LCH.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},340552,1790165792,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":19,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":52},1374391974564,"https://ap-avatar.wpscdn.com/avatar/14000253aa45c000a9e?x-image-process=image/resize,m_fixed,w_180,h_180&k=1779874745381141002","[www.surgicalneurologyint.com](www.surgicalneurologyint.com)  \nSurgical Neurology International  \nEditor-in-Chief: Nancy E. Epstein, MD, Professor of Clinical Neurosurgery, School of Medicine, State U. of NY at Stony Brook.  \nSNI: Spine Editor  \nNancy E. Epstein, MD  \nProfessor of Clinical Neurosurgery, School of Medicine, State U. of NY at Stony Brook  \nOpen Access  \nCase Report  \nRare histiocytic neoplasm: A case report  \nSabrina Maria Genovese1, Jakov Tiefenbach2, Ravi A. Nunna3, Andrew Youkilis3  \n1Department of Neurosurgery, University of Missouri, School of Medicine, Columbia, Missouri, 2Department of Neurosurgery, University of Illinois, College of Medicine, Chicago, Chicago, Illinois, 3Department of Neurosurgery, University of Missouri, Columbia, Missouri, United States.  \nE-mail: *[Sabrina Maria Genovese-sgnnm@umsystem.edu](Sabrina Maria Genovese-sgnnm@umsystem.edu); [Jakov Tiefenbach-jakov.tiefenbach@yahoo.com](Jakov Tiefenbach-jakov.tiefenbach@yahoo.com); [Ravi A. Nunna-nunnars@health.missouri.edu](Ravi A. Nunna-nunnars@health.missouri.edu);  \n[Andrew Youkilis-ayoukilis@health.missouri.edu](Andrew Youkilis-ayoukilis@health.missouri.edu)  \n*Corresponding author:  \nSabrina Maria Genovese, Department of Neurosurgery, University of Missouri, School of Medicine, Columbia, Missouri, United States.  \n[sgnnm@umsystem.edu](sgnnm@umsystem.edu)  \n\n| Received: 21 September 2024\u003Cbr>Accepted: 29 October 2024\u003Cbr>Published: 22 November 2024 |\n| --- |\n| DOI\u003Cbr>10.25259/SNI_795_2024 |\n\nQuick Response Code:  \nABSTRACT  \nBackground: Histiocytic neoplasms are defined by too many histiocytes accumulating in various tissues, including the skin, bones, lymph nodes, and central nervous system. 􀀟ey are uncommon blood-related disorders that constitute \u003C1% of cancers found in soft tissues and lymph nodes. Most referred to as Langerhans cell histiocytosis (LCH) or non-LCH, there are over 100 different sub-types that are divided into five groups. Here, a 76-year-old male presented with an intramedullary thoracic LCH.  \nCase Description: A 76-year-old male presented with the month of slowly progressive bilateral lower extremity weakness (i.e., right > left) accompanied by decreased left-sided sensation below the T7 level. 􀀟e enhanced thoracic magnetic resonance (MR) imaging documented an intradural intramedullary nodule at the T5 level with a syrinx extending from C7 to T10 . 􀀟e patient underwent a T4–T6 laminectomy for complete resection of the lesion. CD163 and CD68 studies highlighted a small, spindled-shaped tumor with occasionally enlarged histiocytes without co-positivity for S100. Pathologically, the lesion was considered an isolated intramedullary thoracic LCH.  \nConclusion: A 76-year-old male presented with progressive paraparesis of 1 month’s duration attributed to an enhanced MR-documented T5 single intramedullary T5 thoracic LCH that was successfully resected.  \nKeywords: Histiocytic neoplasm, Histiocytosis-X, Langerhans cell histiocytosis, Rosai–Dorfman disease, Spine  \nINTRODUCTION  \nHistiocytic neoplasms make up \u003C1% of cancers found in soft tissues and lymph nodes. [5] 􀀟ey include over 100 different sub-types divided into five distinct groups: Langerhans-related, cutaneous and mucocutaneous, malignant histiocytosis, Rosai–Dorfman disease, hemophagocytic lymphohistiocytosis, and macrophage activation syndrome.[4] Langerhans cell histiocytosis (LCH) occurs in 6.5–25% of all osteolytic skeletal cases involving, in descending order, the thoracic (54%), lumbar (35%), and cervical spine (11%) . [1] Metastatic spread of LCH to the spinal cord is occasionally noted, but isolated intramedullary lesions are exceptionally rare.[8,6,12] Here, a 76-yearold male presented with a 1-month progressive paraparesis attributed to a magnetic resonance (MR)-documented isolated intramedullary T5 LCH that was successfully excised.  \nCASE REPORT  \nA 76-year-old male presented with progressive bilateral lower extremity paraparesis of 1 month’s duration acco","cbCaisw7cINUmKoX","https://ap.wps.com/l/cbCaisw7cINUmKoX","pdf",903777,"English","# Abstract\n# Background\n# Case Description\n## Presentation and Imaging\n## Surgery\n## Pathology\n# Conclusion\n# Keywords","[{\"question\":\"What are histiocytic neoplasms and how common are they?\",\"answer\":\"They are defined by abnormal accumulation of histiocytes in multiple tissues, including the skin, bones, lymph nodes, and the central nervous system. They represent less than 1% of cancers in soft tissues and lymph nodes.\"},{\"question\":\"What condition was identified in the case report and where was it located?\",\"answer\":\"The patient had an isolated intramedullary thoracic Langerhans cell histiocytosis. Imaging showed an intradural intramedullary nodule at the T5 level.\"},{\"question\":\"How was the lesion treated and what was the outcome?\",\"answer\":\"The patient underwent a T4–T6 laminectomy for complete resection of the lesion. The abstract indicates successful excision of the intramedullary LCH.\"}]","Rare histiocytic neoplasm - A case report | PDF",1790037286]