[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-447504-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-447504-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","rare-case-report-of-histoplasmosis-osteomyelitis-in-immunocompetent-adult-key-learning-points","Rare Case Report of Histoplasmosis Osteomyelitis in Immunocompetent Adult - Key Learning Points","","A rare localized histoplasmosis osteomyelitis case is presented in an immunocompetent 53-year-old female with chronic multifocal bone involvement at two skeletal sites. Radiographs showed osteolytic lesions, while histopathology confirmed granulomatous inflammation and fungal spores consistent with Histoplasma capsulatum using PAS and Gomori Methenamine Silver stains. Management combined surgical debridement with autologous cancellous bone grafting and external fixation, plus 6 weeks of intravenous Amphotericin B. At 1-year follow-up, complete recovery occurred with no recurrence evidence.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/rare-case-report-of-histoplasmosis-osteomyelitis-in-immunocompetent-adult-key-learning-points/447504/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/rare-case-report-of-histoplasmosis-osteomyelitis-in-immunocompetent-adult-key-learning-points/447504.png","ImageObject",300,407,{"name":42,"@type":43},"anakgang17","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-30","2026-09-29",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",9,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"Can histoplasmosis osteomyelitis occur in immunocompetent individuals?","Question",{"text":63,"@type":64},"Yes. The article emphasizes that fungal osteomyelitis due to Histoplasma capsulatum can occur even in immunocompetent people and may mimic bacterial osteomyelitis.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What diagnostic findings confirmed histoplasmosis in the case?",{"text":68,"@type":64},"Radiographs showed osteolytic lesions, and histopathology demonstrated granulomatous inflammation with fungal spores confirmed by PAS and Gomori Methenamine Silver staining consistent with H. capsulatum.",{"name":70,"@type":61,"acceptedAnswer":71},"What treatment approach led to recovery in this patient?",{"text":72,"@type":64},"The patient received surgical debridement with autologous cancellous bone grafting and temporary external fixation, followed by 6 weeks of intravenous Amphotericin B and protected mobilization. At 1-year follow-up, there was complete recovery with no recurrence.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},447504,1791071984,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":102,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":144,"preview_page_count":4},962090883568,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","Case Report  Journal of Orthopaedic Case Reports 2025 December:15( 12) :Page 264-269   \nRare Case Report of Histoplasmosis Osteomyelitisin Immunocompetent  \nAdult  \nS Vishnu1, Anwesit Mohanty1, S Prakash Nayar², Rohit Kumar1, Debashish Mishra1, Ravipati Aakash1  \nLearning Point of the Article:  \nFungal osteomyelitis due to Histoplasma capsulatum can occur even in immunocompetent individuals; early diagnosis and combined  \nsurgical and antifungal therapy are key to successful management.  \nAbstract  \nIntroduction: Histoplasma capsulatumis a thermally dimorphic fungus that is endemic to North and Central America and rarely encountered in Asia. Musculoskeletal involvement is uncommon, particularly in immunocompetent individuals. This report presents a rare case of localized histoplasmosisosteomyelitis involving two skeletal sites inanimmunocompetent patient.  \nCase Report: A 53-year-old immunocompetent female presented with a 6-month history of chronic, multifocal osteomyelitis involving the right lateral malleolus and left ring finger. She had no systemic symptoms or history suggestive of immunosuppression. Radiographs revealed osteolytic lesions, and histopathological examination demonstrated granulomatous inflammation with fungal spores confirmed by periodic acid-Schiff and Gomori Methenamine Silvers staining, consistent with H. capsulatum. The patient underwent surgical debridement with autologous cancellous bone grafting and temporary external fixation. Post-operatively, she received intravenous Amphotericin B for 6 weeks, followed bya period of protected mobilization.At 1-yearfollow-up, the patient had complete recovery with no evidence ofrecurrence. Conclusion: Localized histoplasmosis osteomyelitis in an immunocompetent host is extremely rare and may mimic bacterial osteomyelitis. A high index of suspicion, timely histopathological diagnosis, and appropriate antifungal therapy combined with surgical management are essential for optimal outcomes.  \nKeywords: Histoplasma capsulatum, histoplasmosisosteomyelitis, immunocompetent, amphotericin B, antifungal therapy, bone infection.  \nIntroduction  \nIn North and Central America, the thermally dimorphic fungus Histoplasma capsulatum is endemic. In immunocompetent individuals, exposure to the bacterium simply causes anasymptomatic infection; in immunocompromised individuals, it can result in lethal disseminated fungemia [1].  \nAlthough the organism is widespread, histoplasmosis cases are uncommon in Asia. Extrapulmonary histoplasmosis is an acquired immunodeficiency syndrome (AIDS)-defining illness  \nin HIV-positive individuals, but still only rarely involves themusculoskeletal system [2, 3]. Only a few cases of H. capsulatum infection in the bone have been documented in the past few decades.  \nOne patient, who showed no symptoms ofa persistent illness or abnormal immune function, was diagnosed and treated for histoplasmosis osteomyelitis that had spread to two bones. We monitored the patient fora year, and she experienced no negative outcomes. We provide this case report to discuss about our  \n\n| \u003Cbr>Access this article online\u003Cbr>\u003Cbr>Website: [www.jocr.co.in](www.jocr.co.in)\u003Cbr>\u003Cbr>DOI:\u003Cbr>[https://doi.org/10.13107/jocr.2025.v15.i12.6530](https://doi.org/10.13107/jocr.2025.v15.i12.6530) | Author’s Photo Gallery |  |  |  |  |  |\n| --- | --- | --- | --- | --- | --- | --- |\n|  | | | | | | |\n|  | \u003Cbr>1Department of Orthopaedics, Kalinga Institute of Medical Sciences, Bhubaneswar, Odisha, India, 2Department of Orthopaedics, Jubilee Mission Medical College, Thrissur, Kerala, India.\u003Cbr>Address of Correspondence:\u003Cbr>Dr. S Vishnu,\u003Cbr>Department of Orthopaedic Surgery, Kalinga Institute of Medical Sciences, Bhubaneswar, Odisha, India.\u003Cbr>E-mail: [rollsroycevishnu95@gmail.com](rollsroycevishnu95@gmail.com) |  |  |  |  |  |\n| Submitted: 09/09/2025; Review: 08/10/2025; Accepted: November 2025; Published: December 2025 |  |  |  |  |  |  |\n| DOI: [https://doi.org/10.13107/jocr.2025.v15.i12.653","cbCaim23b5usYii7","https://ap.wps.com/l/cbCaim23b5usYii7","pdf",9442885,"English","# Learning Point of the Article\n# Abstract\n## Introduction\n## Case Report\n## Conclusion\n# Keywords\n# Introduction\n# Case Report","[{\"question\":\"Can histoplasmosis osteomyelitis occur in immunocompetent individuals?\",\"answer\":\"Yes. The article emphasizes that fungal osteomyelitis due to Histoplasma capsulatum can occur even in immunocompetent people and may mimic bacterial osteomyelitis.\"},{\"question\":\"What diagnostic findings confirmed histoplasmosis in the case?\",\"answer\":\"Radiographs showed osteolytic lesions, and histopathology demonstrated granulomatous inflammation with fungal spores confirmed by PAS and Gomori Methenamine Silver staining consistent with H. capsulatum.\"},{\"question\":\"What treatment approach led to recovery in this patient?\",\"answer\":\"The patient received surgical debridement with autologous cancellous bone grafting and temporary external fixation, followed by 6 weeks of intravenous Amphotericin B and protected mobilization. At 1-year follow-up, there was complete recovery with no recurrence.\"}]","Rare Case Report of Histoplasmosis Osteomyelitis in Immunocompetent Adult - Key Learning Points | PDF",1790720955,15]