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Clinically, RARB low expression predicts better survival, with RARB inversely correlated with MSI status and immune infiltration in vivo, suggesting RARB as a potential therapeutic target.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/rarb-associated-with-msi-affects-progression-and-prognosis-of-gastric-cancer-research/333671/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/rarb-associated-with-msi-affects-progression-and-prognosis-of-gastric-cancer-research/333671.png","ImageObject",300,407,{"name":42,"@type":43},"Oliver","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-02","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",8,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What role does MSI play in gastric cancer according to the document?","Question",{"text":63,"@type":64},"MSI regulates intrinsic tumor behavior and influences survival in gastric cancer patients.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How did the study assess the effect of RARB in gastric cancer cells?",{"text":68,"@type":64},"It compared RARB expression in tumor versus paired paracancer tissues and used RARB knockdown to observe increased proliferation, invasion, and migration in vitro.",{"name":70,"@type":61,"acceptedAnswer":71},"What is the proposed clinical significance of RARB expression levels?",{"text":72,"@type":64},"RARBLow patients show better survival than RARBHigh patients, and RARB is inversely correlated with MSI status and immune infiltrates in vivo.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},333671,1790184045,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,111,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":108,"show_sort_weight":109,"slug":110},7,"Healthcare",40,"healthcare",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":112,"slug":113},30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":55,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145,"preview_page_count":4},8796095461610,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Cai etal. BMCGastroenterology (2024) 24:285 [https://doi.org/10.1186/s12876-024-03339-z](https://doi.org/10.1186/s12876-024-03339-z)  \nBMC Gastroenterology  \nRESEARCH Open Access  \nRARB associated with MSI, affects progression and prognosis of gastric cancer  \nXufan Cai2†, Wenfa Lin2,3†, Fang Wu4, Guangyuan Song5, Zhenyuan Qian4* andYu Wang 1*  \nAbstract  \nMicrosatellite instability (MSI) has been widely acknowledged as an important factor regulating tumor intrinsic biological behavior and affecting the survival of gastric cancer patients. Here, we firstly identified the RARB as agene associated with MSI gastric cancer. RARB was downregulated in human gastric cancer tissues compared topaired paracancerous tissues, Knockdown of RARB accelerated the proliferation, invasion and migration of cancer cells in vitro. Mechanismly, RARB knockdown promoted epithelial-mesenchymal transition (EMT) process of gastric cancer. However, RARBLow patients exhibited better survival compared to RARBHigh patients. Further study revealed that RARB expression was inversely correlated with MSI status and immune infiltrates in vivo. Thus, RARB may be a potential target for the treatment of gastric cancer.  \nKeywords Gastric cancer, MSI, RARB, Tumor immune microenvironment  \n†Xufan Cai and Wenfa Lin contributed equally to this work.  \n*Correspondence: Zhenyuan Qian [13858595659@163.com](13858595659@163.com)[ ](13858595659@163.com)Yu Wang [wlwy4405@163.com](wlwy4405@163.com)  \n1Center for Rehabilitation Medicine, Department of Anesthesiology, Zhejiang Provincial People’s Hospital, The Affiliated People’s Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, China  \n2Graduate School, Zhejiang Chinese Medicine University, Hangzhou, Zhejiang, China  \n3Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Zhejiang Chinese Medical University Hangzhou, Hangzhou, Zhejiang, China  \n4General Surgery, Cancer Center, Department of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People’s Hospital, The Affiliated People’s Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, China  \n5General Surgery, Cancer Center, Department of Hepatobiliary & Pancreatic Surgery, Zhejiang Provincial People’s Hospital, The Affiliated People’s Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, China  \nBackground  \nGastric cancer is a worldwide life and health threatening issue due to its high morbidity and mortality. In recent years, with the gradual deepening of the knowledge in genetic alterations and molecular features of gastric cancer, many new therapeutic methods have appeared [1], but the 5-year survival rate of gastric cancer is still very poor [2]. Therefore, it is of great significance to continue to study in depth the mechanism of the development of gastric cancer and to search for the factors that are related to the prognosis of gastric cancer.  \nThe retinoic acid receptor (RAR) subfamily, including RARα, RARβ and RARγ, belongs to the nuclear receptor (NR) superfamily of transcription factors. RARs form heterodimers with members of the retinoid X receptor (RXR) subfamily and act as ligand-regulated transcription factors through binding specific RA response elements (RAREs) located in target genes promoters [3]. RARs play a crucial role in many process, including cell proliferation, apoptosis and metabolism [4, 5]. Retinoid acid receptor B (RAR-β), a subtype of RAR, has been demonstrated to be downregulated in different types of  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted materia","cbCaibBrXxWYWaxg","https://ap.wps.com/l/cbCaibBrXxWYWaxg","pdf",6172197,11,"English","# Abstract\n# Background\n# RARB and MSI relationship\n# RAR/RXR signaling and therapeutic context\n# Regulatory effects and clinical implications","[{\"question\":\"What role does MSI play in gastric cancer according to the document?\",\"answer\":\"MSI regulates intrinsic tumor behavior and influences survival in gastric cancer patients.\"},{\"question\":\"How did the study assess the effect of RARB in gastric cancer cells?\",\"answer\":\"It compared RARB expression in tumor versus paired paracancer tissues and used RARB knockdown to observe increased proliferation, invasion, and migration in vitro.\"},{\"question\":\"What is the proposed clinical significance of RARB expression levels?\",\"answer\":\"RARBLow patients show better survival than RARBHigh patients, and RARB is inversely correlated with MSI status and immune infiltrates in vivo.\"}]","RARB associated with MSI, affects progression and prognosis of gastric cancer - Research | PDF",1790003556,28]